Managing risks in drug discovery: reproducibility of published findings

Why and how have drug discovery strategies in pharma changed? What are the new mindsets?

(2016) Serge Mignani et al.   DRUG DISCOVERY TODAY

Improving R&D productivity

(2015) Katarzyna Smietana et al.   NATURE REVIEWS DRUG DISCOVERY

Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events

(2015) Jennifer G. Robinson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events

(2015) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuroprotective therapies: Preclinical reproducibility is only part of the problem

(2015) Michael Tymianski   Science Translational Medicine

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia

(2015) Gemma Llovera et al.   Science Translational Medicine

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

Biomedical research: increasing value, reducing waste

(2014) Malcolm R Macleod et al.   LANCET

Increasing value and reducing waste in research design, conduct, and analysis

(2014) John P A Ioannidis et al.   LANCET

Technology: The $1,000 genome

(2014) Erika Check Hayden   NATURE

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Fixing problems with cell lines

(2014) Jon R. Lorsch et al.   SCIENCE

On the reproducibility of science: unique identification of research resources in the biomedical literature

(2013) Nicole A. Vasilevsky et al.   PeerJ

Third-generation sequencing techniques and applications to drug discovery

(2012) Fatih Ozsolak   Expert Opinion on Drug Discovery

Translatability scoring in drug development: eight case studies

(2012) Alexandra Wendler et al.   Journal of Translational Medicine

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites

(2011) M. Zhao et al.   CLINICAL CANCER RESEARCH

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Negative results are disappearing from most disciplines and countries

(2011) Daniele Fanelli   SCIENTOMETRICS

Do Pressures to Publish Increase Scientists' Bias? An Empirical Support from US States Data

(2010) Daniele Fanelli   PLoS One

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Assessing the translatability of drug projects: what needs to be scored to predict success?

(2009) Martin Wehling   NATURE REVIEWS DRUG DISCOVERY