Intracellular Mono-ADP-Ribosylation in Signaling and Disease

SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

(2016) Ronald A. McCord et al.   Aging-US

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair

(2016) Michael Van Meter et al.   Aging-US

Sirtuin-4 (SIRT4) is downregulated and associated with some clinicopathological features in gastric adenocarcinoma

(2015) Guoyu Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Tumour-suppressive function of SIRT4 in human colorectal cancer

(2015) M Miyo et al.   BRITISH JOURNAL OF CANCER

Putative tumor suppression function of SIRT6 in endometrial cancer

(2015) Tomohiko Fukuda et al.   FEBS LETTERS

Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality

(2015) Shaimaa Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein

(2015) Tobias Karlberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Regulation by Poly(ADP-Ribose) Polymerases

(2015) Florian J. Bock et al.   MOLECULAR CELL

Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens

(2015) Johannes Gregor Matthias Rack et al.   MOLECULAR CELL

Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

(2015) Peter Bai   MOLECULAR CELL

The Promise of Proteomics for the Study of ADP-Ribosylation

(2015) Casey M. Daniels et al.   MOLECULAR CELL

A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress

(2015) Claudia M. Nicolae et al.   NUCLEIC ACIDS RESEARCH

SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer

(2014) M. Ming et al.   CANCER RESEARCH

ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses

(2014) Gaia Fabrizio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3

(2014) Carole Beck et al.   EXPERIMENTAL CELL RESEARCH

Identification of ADP-ribosylated peptides and ADP-ribose acceptor sites

(2014) Florian Rosenthal   Frontiers in Bioscience-Landmark

The ADP-ribosyltransferase PARP10/ARTD10 Interacts with Proliferating Cell Nuclear Antigen (PCNA) and Is Required for DNA Damage Tolerance

(2014) Claudia M. Nicolae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP12, an Interferon-stimulated Gene Involved in the Control of Protein Translation and Inflammation

(2014) Iain Welsby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The alternate triad motif of the poly(ADP-ribose) polymerase-like domain of the human zinc finger antiviral protein is essential for its antiviral activity

(2014) S. Glasker et al.   JOURNAL OF GENERAL VIROLOGY

DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells

(2014) Samia B Bachmann et al.   Molecular Cancer

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

MACROD2overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers

(2014) Morassa Mohseni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Antiviral innate immunity and stress granule responses

(2014) Koji Onomoto et al.   TRENDS IN IMMUNOLOGY

Family-wide analysis of poly(ADP-ribose) polymerase activity

(2014) Sejal Vyas et al.   Nature Communications

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts

(2014) Matthew D. Daugherty et al.   PLoS Genetics

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

(2013) Seung Min Jeong et al.   CANCER CELL

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation

(2013) Karla LH Feijs et al.   Cell Communication and Signaling

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

(2013) Reza Sharifi et al.   EMBO JOURNAL

Caspase-dependent cleavage of the mono-ADP-ribosyltransferase ARTD10 interferes with its pro-apoptotic function

(2013) Nicolas Herzog et al.   FEBS Journal

Expanding functions of intracellular resident mono-ADP-ribosylation in cell physiology

(2013) Karla L. H. Feijs et al.   FEBS Journal

A role of intracellular mono-ADP-ribosylation in cancer biology

(2013) Emanuele S. Scarpa et al.   FEBS Journal

Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients

(2013) Jens U. Marquardt et al.   HEPATOLOGY

Unfolded Protein Response Signaling and Metabolic Diseases

(2013) Jaemin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAL1/ARTD9 represses the anti-proliferative and pro-apoptotic IFN -STAT1-IRF1-p53 axis in diffuse large B-cell lymphoma

(2013) R. Camicia et al.   JOURNAL OF CELL SCIENCE

B Cell-Intrinsic and -Extrinsic Regulation of Antibody Responses by PARP14, an Intracellular (ADP-Ribosyl)Transferase

(2013) S. H. Cho et al.   JOURNAL OF IMMUNOLOGY

Interferon-Stimulated Poly(ADP-Ribose) Polymerases Are Potent Inhibitors of Cellular Translation and Virus Replication

(2013) S. Atasheva et al.   JOURNAL OF VIROLOGY

Sirtuin 6: a review of biological effects and potential therapeutic properties

(2013) Jade M. Beauharnois et al.   Molecular BioSystems

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal-regulated kinase signaling pathway

(2013) ZHI-GAO ZHANG et al.   Molecular Medicine Reports

Erratum: Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation

(2013) Karla L. H. Feijs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases

(2013) Florian Rosenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation

(2013) Gytis Jankevicius et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PARP-14 Binds Specific DNA Sequences to Promote Th2 Cell Gene Expression

(2013) Jonathan P. Riley et al.   PLoS One

Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains

(2013) Alexandra H. Forst et al.   STRUCTURE

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10

(2013) Patricia Verheugd et al.   Nature Communications

Inhibition of Hepatitis B Virus Replication by the Host Zinc Finger Antiviral Protein

(2013) Richeng Mao et al.   PLoS Pathogens

Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics

(2013) Yewei Liu et al.   Protein & Cell

Estrogen and Cancer

(2012) Jing Liang et al.   Annual Review of Physiology

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62

(2012) Henning Kleine et al.   Cell Communication and Signaling

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Ubiquitination in signaling to and activation of IKK

(2012) Zhijian J. Chen   IMMUNOLOGICAL REVIEWS

PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development

(2012) HANDAN TUNCEL et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Poly (ADP-ribose) polymerase 14 and its enzyme activity regulates TH2 differentiation and allergic airway disease

(2012) Purvi Mehrotra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sirtuin Catalysis and Regulation

(2012) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

(2012) Joseph E. Chambers et al.   JOURNAL OF CELL BIOLOGY

New PARP Gene with an Anti-Alphavirus Function

(2012) S. Atasheva et al.   JOURNAL OF VIROLOGY

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

(2012) Lihua Min et al.   NATURE CELL BIOLOGY

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response

(2012) Miri Jwa et al.   NATURE CELL BIOLOGY

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA

(2012) Shoudeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation

(2012) Laura MacPherson et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma

(2012) A Barbarulo et al.   ONCOGENE

PARP16/ARTD15 Is a Novel Endoplasmic-Reticulum-Associated Mono-ADP-Ribosyltransferase That Interacts with, and Modifies Karyopherin-ß1

(2012) Simone Di Paola et al.   PLoS One

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

(2012) Z. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm

(2012) Anthony K.L. Leung et al.   RNA Biology

Regulation of Sirtuin Function by Posttranslational Modifications

(2012) Franziska Flick et al.   Frontiers in Pharmacology

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

(2011) Michael Van Meter et al.   CELL CYCLE

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

(2011) T. Kuri et al.   JOURNAL OF GENERAL VIROLOGY

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family

(2011) S. H. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

(2011) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Expression and RNA-binding of human zinc-finger antiviral protein

(2010) Mi Suk Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

“Without Ub I am nothing”: NEMO as a multifunctional player in ubiquitin-mediated control of NF-κB activation

(2010) Jérémie Gautheron et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation

(2010) Purvi Mehrotra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA

(2010) Olga Loseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma

(2010) Hong-Qing Xi   WORLD JOURNAL OF GASTROENTEROLOGY

PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells

(2009) S. H. Cho et al.   BLOOD

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)

(2009) Eléonore Beurel et al.   TRENDS IN IMMUNOLOGY

The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice

(2009) Eunhye Park et al.   VIROLOGY

Clinicopathological significance of LRP16 protein in 336 gastric carcinoma patients

(2009) Ya-Zhuo Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular Mechanisms of the Cytotoxicity of ADP-Ribosylating Toxins

(2008) Qing Deng et al.   Annual Review of Microbiology

P Bodies, Stress Granules, and Viral Life Cycles

(2008) Carla J. Beckham et al.   Cell Host & Microbe

Vaults and the major vault protein: Novel roles in signal pathway regulation and immunity

(2008) W. Berger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The single-macro domain protein LRP16 is an essential cofactor of androgen receptor

(2008) J Yang et al.   ENDOCRINE-RELATED CANCER

Differential Activities of Cellular and Viral Macro Domain Proteins in Binding of ADP-Ribose Metabolites

(2008) Maarit Neuvonen et al.   JOURNAL OF MOLECULAR BIOLOGY

Mouse Hepatitis Virus Liver Pathology Is Dependent on ADP-Ribose-1''-Phosphatase, a Viral Function Conserved in the Alpha-Like Supergroup

(2008) K. K. Eriksson et al.   JOURNAL OF VIROLOGY

Substrate-Assisted Catalysis by PARP10 Limits Its Activity to Mono-ADP-Ribosylation

(2008) Henning Kleine et al.   MOLECULAR CELL

The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse

(2002) Gustavo Glowacki et al.   PROTEIN SCIENCE