Ubiquitination in signaling to and activation of IKK

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

The E3 Ubiquitin Ligase Mind Bomb-2 (MIB2) Protein Controls B-cell CLL/Lymphoma 10 (BCL10)-dependent NF-κB Activation

(2011) Cinthia C. Stempin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

(2011) Catherine E. Gleason et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

(2011) Sambit K. Nanda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct, Noncatalytic Mechanism of IKK Inhibition by A20

(2011) Brian Skaug et al.   MOLECULAR CELL

The Ripoptosome: Death Decision in the Cytosol

(2011) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses

(2011) D. E. Zak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

Expanding role of ubiquitination in NF-κB signaling

(2010) Siqi Liu et al.   CELL RESEARCH

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

(2010) Jasmin N Dynek et al.   EMBO JOURNAL

Inhibition of NF-κB Signaling Retards Eosinophilic Dermatitis in SHARPIN-Deficient Mice

(2010) Yanhua Liang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains

(2010) Shengkai Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Ubiquitin in NF-κB Regulatory Pathways

(2009) Brian Skaug et al.   Annual Review of Biochemistry

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

(2009) Qian Yin et al.   BIOCHEMISTRY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

(2009) E Laplantine et al.   EMBO JOURNAL

CARMA1-mediated NF-κB and JNK activation in lymphocytes

(2009) Marzenna Blonska et al.   IMMUNOLOGICAL REVIEWS

A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β

(2009) Ming Xu et al.   MOLECULAR CELL

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3

(2009) Wenwen Zeng et al.   MOLECULAR CELL

Structural Basis for Recognition of Diubiquitins by NEMO

(2009) Yu-Chih Lo et al.   MOLECULAR CELL

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

(2008) Kim Newton et al.   CELL

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

RNA recognition and signal transduction by RIG-I-like receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNOLOGICAL REVIEWS

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA