Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

The ascending pathophysiology of cholestatic liver disease

(2017) Peter L.M. Jansen et al.   HEPATOLOGY

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests

(2016) Vaibhav Shinde et al.   ARCHIVES OF TOXICOLOGY

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

(2016) Marilena Colaianna et al.   ARCHIVES OF TOXICOLOGY

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

(2016) Mardas Daneshian et al.   ARCHIVES OF TOXICOLOGY

Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis

(2016) Marcelo Dutra Arbo et al.   ARCHIVES OF TOXICOLOGY

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

(2016) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Comparative analysis of 3D culture methods on human HepG2 cells

(2016) Claudia Luckert et al.   ARCHIVES OF TOXICOLOGY

Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition

(2016) Daniela Deharde et al.   ARCHIVES OF TOXICOLOGY

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes

(2016) Umesh Chaudhari et al.   ARCHIVES OF TOXICOLOGY

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

(2016) Ahmed Ghallab et al.   JOURNAL OF HEPATOLOGY

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

(2015) Eugen Rempel et al.   ARCHIVES OF TOXICOLOGY

2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells

(2015) Xuezhong Gong et al.   ARCHIVES OF TOXICOLOGY

Bile canalicular dynamics in hepatocyte sandwich cultures

(2015) Raymond Reif et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead

(2015) Gang Liu et al.   ARCHIVES OF TOXICOLOGY

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

(2015) Jin-Young Kim et al.   JOURNAL OF BIOTECHNOLOGY

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells

(2015) Patricio Godoy et al.   JOURNAL OF HEPATOLOGY

Modular Microfluidic System for Emulation of Human Phase I/Phase II Metabolism

(2014) Thomas Kampe et al.   ANALYTICAL CHEMISTRY

Toxicogenomics directory of chemically exposed human hepatocytes

(2014) Marianna Grinberg et al.   ARCHIVES OF TOXICOLOGY

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

(2014) Tanja Waldmann et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Unique Metabolic Features of Stem Cells, Cardiomyocytes, and Their Progenitors

(2014) John Antonydas Gaspar et al.   CIRCULATION RESEARCH

Featured Article: Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells

(2014) Elisa Pfeiffer et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration

(2014) Freimut Schliess et al.   HEPATOLOGY

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

(2012) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

Acute liver failure

(2010) William Bernal et al.   LANCET

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

(2010) S. Hoehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA