A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

The dawning of a new age of toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Food for thought … on the evolution of toxicology and the phasing out of animal testing

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

(2015) Anna Bal-Price et al.   ARCHIVES OF TOXICOLOGY

From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data

(2015) Jörg Rahnenführer et al.   ARCHIVES OF TOXICOLOGY

Modeling Chemotherapeutic Neurotoxicity with Human Induced Pluripotent Stem Cell-Derived Neuronal Cells

(2015) Heather E. Wheeler et al.   PLoS One

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects

(2014) Nina V. Balmer et al.   ARCHIVES OF TOXICOLOGY

Toxicogenomics directory of chemically exposed human hepatocytes

(2014) Marianna Grinberg et al.   ARCHIVES OF TOXICOLOGY

Epigenetics and Transcriptomics to Detect Adverse Drug Effects in Model Systems of Human Development

(2014) Nina V. Balmer et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

CellNet: Network Biology Applied to Stem Cell Engineering

(2014) Patrick Cahan et al.   CELL

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

(2014) Tanja Waldmann et al.   CHEMICAL RESEARCH IN TOXICOLOGY

MicroRNA Profiling as Tool for In Vitro Developmental Neurotoxicity Testing: The Case of Sodium Valproate

(2014) Lena Smirnova et al.   PLoS One

Lineage-Specific Regulation of Epigenetic Modifier Genes in Human Liver and Brain

(2014) Matthias K. Weng et al.   PLoS One

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

(2014) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

Consensus report on the future of animal-free systemic toxicity testing

(2014) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

miRNA expression profiling in a human stem cell-based model as a tool for developmental neurotoxicity testing

(2013) Giorgia Pallocca et al.   CELL BIOLOGY AND TOXICOLOGY

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

(2012) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells

(2012) Bastian Zimmer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Compound selection for in vitro modeling of developmental neurotoxicity

(2012) Suzanne Kadereit   Frontiers in Bioscience-Landmark

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome

(2012) Nina V. Balmer et al.   HUMAN MOLECULAR GENETICS

Extensive Transcriptional Regulation of Chromatin Modifiers during Human Neurodevelopment

(2012) Matthias K. Weng et al.   PLoS One

Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells

(2012) Kesavan Meganathan et al.   PLoS One

Use of Antiepileptic Medications in Pregnancy in Relation to Risks of Birth Defects

(2011) Martha M. Werler et al.   ANNALS OF EPIDEMIOLOGY

Methylmercury and Brain Development: Imprecision and Underestimation of Developmental Neurotoxicity in Humans

(2011) Philippe Grandjean et al.   MOUNT SINAI JOURNAL OF MEDICINE

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

(2011) Christoph van Thriel et al.   NEUROTOXICOLOGY

Removing Batch Effects in Analysis of Expression Microarray Data: An Evaluation of Six Batch Adjustment Methods

(2011) Chao Chen et al.   PLoS One

Comparison of MeHg-induced toxicogenomic responses across in vivo and in vitro models used in developmental toxicology

(2011) Joshua F. Robinson et al.   REPRODUCTIVE TOXICOLOGY

Development of a Neural Teratogenicity Test Based on Human Embryonic Stem Cells: Response to Retinoic Acid Exposure

(2011) Silvia Colleoni et al.   TOXICOLOGICAL SCIENCES

Transcriptomic Concentration-Response Evaluation of Valproic Acid, Cyproconazole, and Hexaconazole in the Neural Embryonic Stem Cell Test (ESTn)

(2011) Peter T. Theunissen et al.   TOXICOLOGICAL SCIENCES

Assessment of Chemical-Induced Impairment of Human Neurite Outgrowth by Multiparametric Live Cell Imaging in High-Density Cultures

(2011) Nina V. Stiegler et al.   TOXICOLOGICAL SCIENCES

An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure

(2010) Muriel J. Harris et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation

(2010) S Jagtap et al.   BRITISH JOURNAL OF PHARMACOLOGY

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

(2010) B Zimmer et al.   CELL DEATH AND DIFFERENTIATION

Quantitative assessment of neurite outgrowth in human embryonic stem cell-derived hN2™ cells using automated high-content image analysis

(2010) Joshua A. Harrill et al.   NEUROTOXICOLOGY

Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity

(2010) Kim Kultima et al.   REPRODUCTIVE TOXICOLOGY

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles

(2009) Elodie Portales-Casamar et al.   NUCLEIC ACIDS RESEARCH

Valproic Acid–Induced Deregulation In Vitro of Genes Associated In Vivo with Neural Tube Defects

(2009) Måns Jergil et al.   TOXICOLOGICAL SCIENCES

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL