Molecular Targets in Hepatocarcinogenesis and Implications for Therapy
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Molecular Targets in Hepatocarcinogenesis and Implications for Therapy
Authors
Keywords
-
Journal
Journal of Clinical Medicine
Volume 7, Issue 8, Pages 213
Publisher
MDPI AG
Online
2018-08-13
DOI
10.3390/jcm7080213
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Indoleamine 2,3-dioxygenase provides adaptive resistance to immune checkpoint inhibitors in hepatocellular carcinoma
- (2018) Zachary J. Brown et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Efficacy and Safety of Neoadjuvant Treatment with Bevacizumab, Liposomal Doxorubicin, Cyclophosphamide and Paclitaxel Combination in Locally/Regionally Advanced, HER2-Negative, Grade III at Premenopausal Status Breast Cancer: A Phase II Study
- (2018) Ekaterini C. Tampaki et al. CLINICAL DRUG INVESTIGATION
- Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment?
- (2018) Andreia Alves et al. CURRENT CANCER DRUG TARGETS
- Farnesoid X Receptor Activation Enhances Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells
- (2018) Masahiko Kainuma et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Impact of baseline characteristics on outcomes of advanced HCC patients treated with sorafenib: a secondary analysis of a phase III study
- (2018) Omar Abdel-Rahman JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- β1 integrin-mediated multicellular resistance in hepatocellular carcinoma through activation of the FAK/Akt pathway
- (2018) Tao Tian et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Efficacy and Safety of apatinib in patients with intermediate/advanced hepatocellular carcinoma
- (2018) Wen-Chang Yu et al. MEDICINE
- The immunology of hepatocellular carcinoma
- (2018) Marc Ringelhan et al. NATURE IMMUNOLOGY
- Urokinase Type Plasminogen Activator and the Molecular Mechanisms of its Regulation in Cancer
- (2018) Juan F. Santibanez PROTEIN AND PEPTIDE LETTERS
- Tumor Hypoxia As an Enhancer of Inflammation-Mediated Metastasis: Emerging Therapeutic Strategies
- (2018) Josh W. DiGiacomo et al. Targeted Oncology
- Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis
- (2017) Yongdong Niu et al. HEPATOLOGY
- Aflatoxin B1 exposure increases the risk of cirrhosis and hepatocellular carcinoma in chronic hepatitis B virus carriers
- (2017) Yu-Ju Chu et al. INTERNATIONAL JOURNAL OF CANCER
- New Insights into the Role of Autophagy in Tumor Immune Microenvironment
- (2017) Chia-Jung Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis
- (2017) Meng-Yu Wu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma
- (2017) Austin G. Duffy et al. JOURNAL OF HEPATOLOGY
- Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
- (2017) Anthony B El-Khoueiry et al. LANCET
- Nifuroxazide prompts antitumor immune response of TCL-loaded DC in mice with orthotopically-implanted hepatocarcinoma
- (2017) Tiesuo Zhao et al. ONCOLOGY REPORTS
- Transcriptional activation of PD-L1 by Sox2 contributes to the proliferation of hepatocellular carcinoma cells
- (2017) Feng Zhong et al. ONCOLOGY REPORTS
- Targeting the PD-L1/DNMT1 axis in acquired resistance to sorafenib in human hepatocellular carcinoma
- (2017) Jianhua Liu et al. ONCOLOGY REPORTS
- Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study
- (2017) Bruno Märkl et al. Gastroenterology Research and Practice
- Apatinib is effective for treatment of advanced hepatocellular carcinoma
- (2017) Yinlong Kong et al. Oncotarget
- YAP-associated chromosomal instability and cholangiocarcinoma in mice
- (2017) Sumera Rizvi et al. Oncotarget
- Thalidomide combined with transcatheter artierial chemoembolzation for primary hepatocellular carcinoma: a systematic review and meta-analysis
- (2017) De-Dong Cao et al. Oncotarget
- Cross-talk mechanism between endothelial cells and hepatocellular carcinoma cells via growth factors and integrin pathway promotes tumor angiogenesis and cell migration
- (2017) Tang Feng et al. Oncotarget
- Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors
- (2017) Concetta Di Mauro et al. Scientific Reports
- Efficacy, Safety, and Potential Biomarkers of Sunitinib and Transarterial Chemoembolization (TACE) Combination in Advanced Hepatocellular Carcinoma (HCC)
- (2016) Venkata K. Pokuri et al. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
- Sorafenib with or without everolimus in patients with advanced hepatocellular carcinoma (HCC): a randomized multicenter, multinational phase II trial (SAKK 77/08 and SASL 29)
- (2016) D. Koeberle et al. ANNALS OF ONCOLOGY
- FLIPL is critical for aerobic glycolysis in hepatocellular carcinoma
- (2016) Shixiong Lei et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Thrombosis recanalization by paeoniflorin through the upregulation of urokinase-type plasminogen activator via the MAPK signaling pathway
- (2016) SONGSHAN YE et al. Molecular Medicine Reports
- Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor
- (2016) Ai Hua Zhang et al. ORGANIC LETTERS
- Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases
- (2016) N. N. Rahbari et al. Science Translational Medicine
- Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma
- (2016) Edward K. Geissler et al. TRANSPLANTATION
- Clinicopathological and prognostic significance of Yes-associated protein expression in hepatocellular carcinoma and hepatic cholangiocarcinoma
- (2016) Hao Wu et al. TUMOR BIOLOGY
- Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment
- (2016) Valery Vilchez WORLD JOURNAL OF GASTROENTEROLOGY
- Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
- (2016) Yunlong Yang et al. Nature Communications
- uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy
- (2016) Miguel Angel Pavón et al. Oncotarget
- Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling
- (2016) So-Young Hwang et al. Cell Reports
- Expanded and Activated Natural Killer Cells for Immunotherapy of Hepatocellular Carcinoma
- (2016) T. Kamiya et al. Cancer Immunology Research
- Phase II study of the GPC3-derived peptide vaccine as an adjuvant therapy for hepatocellular carcinoma patients
- (2016) Yu Sawada et al. OncoImmunology
- Hepatocellular carcinoma
- (2016) Josep M. Llovet et al. Nature Reviews Disease Primers
- A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet
- (2016) Gabsik Yang et al. Scientific Reports
- Global Cancer Incidence and Mortality Rates and Trends--An Update
- (2015) L. A. Torre et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell-like Behaviors Contributing to Disease Progression
- (2015) H. Hayashi et al. CANCER RESEARCH
- Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma
- (2015) Cheolhee Won et al. HEPATOLOGY
- Linifanib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma: Results of a Randomized Phase III Trial
- (2015) Calin Cainap et al. JOURNAL OF CLINICAL ONCOLOGY
- Safety and Antitumor Activity of Anti–PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer
- (2015) Junzo Hamanishi et al. JOURNAL OF CLINICAL ONCOLOGY
- VEGF-A modulates expression of inhibitory checkpoints on CD8+T cells in tumors
- (2015) Thibault Voron et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma
- (2015) Oscar W.H. Yeung et al. JOURNAL OF HEPATOLOGY
- Phase I trial of active specific immunotherapy with autologous dendritic cells pulsed with autologous irradiated tumor stem cells in hepatitis B-positive patients with hepatocellular carcinoma
- (2015) Xiaojin Wang et al. JOURNAL OF SURGICAL ONCOLOGY
- Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
- (2015) Kornelius Schulze et al. NATURE GENETICS
- The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
- (2015) Yun-Hee Youm et al. NATURE MEDICINE
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- Toward understanding and exploiting tumor heterogeneity
- (2015) Ash A Alizadeh et al. NATURE MEDICINE
- Programmed probiotics light up liver cancer in urine
- (2015) Katrina Ray Nature Reviews Gastroenterology & Hepatology
- Hepatocellular Carcinoma: A Phase II Randomized Controlled Double-Blind Trial of Transarterial Chemoembolization in Combination with Biweekly Intravenous Administration of Bevacizumab or a Placebo
- (2015) Matthias Pinter et al. RADIOLOGY
- TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells
- (2015) Ang Lin et al. OncoImmunology
- FXR and liver carcinogenesis
- (2014) Xiong-fei Huang et al. ACTA PHARMACOLOGICA SINICA
- Mechanisms and Functions of Inflammasomes
- (2014) Mohamed Lamkanfi et al. CELL
- The PD-1/PD-Ls pathway and autoimmune diseases
- (2014) Suya Dai et al. CELLULAR IMMUNOLOGY
- Genomic portrait of resectable hepatocellular carcinomas: Implications ofRB1andFGF19aberrations for patient stratification
- (2014) Sung-Min Ahn et al. HEPATOLOGY
- Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis
- (2014) Jean Charles Nault et al. HEPATOLOGY
- Integrins αvβ6, α6β4 and α3β1 are down-regulated in cholangiolocellular carcinoma but not cholangiocarcinoma
- (2014) Yurie Soejima et al. HEPATOLOGY RESEARCH
- Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation
- (2014) Hiroe Honda et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Inflammasome activation has an important role in the development of spontaneous colitis
- (2014) J Zhang et al. Mucosal Immunology
- Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease
- (2014) John R. Lukens et al. Seminars in Immunopathology
- Tissue expression, serum and salivary levels of vascular endothelial growth factor in patients with HNSCC
- (2014) Azadeh Andisheh-Tadbir et al. Brazilian Journal of Otorhinolaryngology
- Toll-Like Receptor Signaling Pathways
- (2014) Takumi Kawasaki et al. Frontiers in Immunology
- Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2
- (2013) Feng Yin et al. CELL
- Exposure-Response (Safety) Analysis to Identify Linifanib Dose for a Phase III Study in Patients With Hepatocellular Carcinoma
- (2013) Yi-Lin Chiu et al. CLINICAL THERAPEUTICS
- Expression of stemness markers (CD133 and EpCAM) in prognostication of hepatocellular carcinoma
- (2013) Anthony W H Chan et al. HISTOPATHOLOGY
- Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma
- (2013) Jiuwei Cui et al. INTERNATIONAL JOURNAL OF CANCER
- Sunitinib Versus Sorafenib in Advanced Hepatocellular Cancer: Results of a Randomized Phase III Trial
- (2013) Ann-Lii Cheng et al. JOURNAL OF CLINICAL ONCOLOGY
- The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies
- (2013) Li Shi et al. Journal of Hematology & Oncology
- A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
- (2013) Bruno Sangro et al. JOURNAL OF HEPATOLOGY
- Recent Developments of Small Molecule PI3K/mTOR Dual Inhibitors
- (2013) Yan-Na Liu et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
- (2013) Jean Charles Nault et al. Nature Communications
- v Integrins in Angiogenesis and Cancer
- (2013) S. M. Weis et al. Cold Spring Harbor Perspectives in Medicine
- Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
- (2012) Dianne H. Dapito et al. CANCER CELL
- Wnt/β-Catenin Signaling and Disease
- (2012) Hans Clevers et al. CELL
- Phase I Trial of a Glypican-3-Derived Peptide Vaccine for Advanced Hepatocellular Carcinoma: Immunologic Evidence and Potential for Improving Overall Survival
- (2012) Y. Sawada et al. CLINICAL CANCER RESEARCH
- Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib
- (2012) Kristin Wahl et al. HEPATOLOGY
- Role of sorafenib in the treatment of advanced hepatocellular carcinoma: An update
- (2012) Angela Gauthier et al. HEPATOLOGY RESEARCH
- Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1
- (2012) Olaf Groß et al. IMMUNITY
- Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation
- (2012) T. Fujino et al. JOURNAL OF BIOCHEMISTRY
- Expression of Urokinase-Type Plasminogen Activator (uPA), its Receptor (uPAR), and Inhibitor (PAI-1) in Human Breast Carcinomas and Their Clinical Relevance
- (2012) Sarah A. Andres et al. JOURNAL OF CLINICAL LABORATORY ANALYSIS
- Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease
- (2012) Sorina Georgiana Boaru et al. Journal of Inflammation-London
- In vitro angiogenesis assay for the study of cell-encapsulation therapy
- (2012) Choong Kim et al. LAB ON A CHIP
- Restriction of intestinal stem cell expansion and the regenerative response by YAP
- (2012) Evan R. Barry et al. NATURE
- Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
- (2012) Cécile Guichard et al. NATURE GENETICS
- Inflammasomes in carcinogenesis and anticancer immune responses
- (2012) Laurence Zitvogel et al. NATURE IMMUNOLOGY
- Immunological and Molecular Correlates of Disease Recurrence after Liver Resection for Hepatocellular Carcinoma
- (2012) Elisabetta Cariani et al. PLoS One
- FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model
- (2012) Ulrich Deuschle et al. PLoS One
- NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis
- (2012) M. Inoue et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interferon- Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome
- (2012) M. Inoue et al. Science Signaling
- Immunotherapy of hepatocellular carcinoma
- (2012) Angela D. Pardee et al. OncoImmunology
- Natural Innate and Adaptive Immunity to Cancer
- (2011) Matthew D. Vesely et al. Annual Review of Immunology
- p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF- B
- (2011) R. F. Johnson et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Factors That Affect Risk for Hepatocellular Carcinoma and Effects of Surveillance
- (2011) Ju Dong Yang et al. Clinical Gastroenterology and Hepatology
- Targeting integrins in hepatocellular carcinoma
- (2011) Yanhua Wu et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Constitutional telomerase mutations are genetic risk factors for cirrhosis
- (2011) Rodrigo T. Calado et al. HEPATOLOGY
- Telomerase gene mutations are associated with cirrhosis formation
- (2011) Daniel Hartmann et al. HEPATOLOGY
- Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
- (2011) Timea Csak et al. HEPATOLOGY
- Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
- (2011) Taro Kawai et al. IMMUNITY
- Sorafenib: complexities of Raf-dependent and Raf-independent signaling are now unveiled
- (2011) Yasunobu Matsuda et al. Medical Molecular Morphology
- NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma
- (2011) Tom Luedde et al. Nature Reviews Gastroenterology & Hepatology
- Hypoxia and Inflammation
- (2011) Holger K. Eltzschig et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hepatocellular carcinoma-specific immunotherapy with synthesized α1,3- galactosyl epitope-pulsed dendritic cells and cytokine-induced killer cells
- (2011) Ying Qiu WORLD JOURNAL OF GASTROENTEROLOGY
- Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease
- (2010) S Behboudi et al. BRITISH JOURNAL OF CANCER
- Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma
- (2010) Thomas Yau et al. CANCER
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
- NF-κB and STAT3 – key players in liver inflammation and cancer
- (2010) Guobin He et al. CELL RESEARCH
- Inflammasomes: current understanding and open questions
- (2010) Franz Bauernfeind et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma
- (2010) George P. Kim et al. INVESTIGATIONAL NEW DRUGS
- Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome
- (2010) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
- (2010) D. Gris et al. JOURNAL OF IMMUNOLOGY
- How the Noninflammasome NLRs Function in the Innate Immune System
- (2010) J. P. Y. Ting et al. SCIENCE
- The Inflammasomes: Guardians of the Body
- (2009) Fabio Martinon et al. Annual Review of Immunology
- Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways
- (2009) Salvatore Papa et al. BIOLOGICAL CHEMISTRY
- Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways
- (2009) M. Segarra et al. HAEMATOLOGICA
- Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
- (2009) François Ghiringhelli et al. NATURE MEDICINE
- The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
- (2009) C. Cayrol et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The NLRP3 inflammasome: A sensor of immune danger signals
- (2009) Suzanne L. Cassel et al. SEMINARS IN IMMUNOLOGY
- Immunotherapy of hepatocellular carcinoma with a vaccine based on xenogeneic homologous α fetoprotein in mice
- (2008) Wei Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- NLR, the nucleotide-binding domain leucine-rich repeat containing gene family
- (2008) Zhengmao Ye et al. CURRENT OPINION IN IMMUNOLOGY
- A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells
- (2008) Bastian Hoechst et al. GASTROENTEROLOGY
- Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma
- (2008) Augusto Villanueva et al. GASTROENTEROLOGY
- High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection
- (2008) Tong Ding et al. HUMAN PATHOLOGY
- Sirolimus inhibits the growth and metastatic progression of hepatocellular carcinoma
- (2008) Zheng Wang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma
- (2008) Xiao-Dong Zhu et al. JOURNAL OF CLINICAL ONCOLOGY
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now