Targeting integrins in hepatocellular carcinoma

Tumor-Selective Response to Antibody-Mediated Targeting of αvβ3 Integrin in Ovarian Cancer

(2015) Charles N. Landen et al.   NEOPLASIA

RGD-FasL Induces Apoptosis in Hepatocellular Carcinoma

(2010) Zhongchen Liu et al.   Cellular & Molecular Immunology

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Targeting transforming growth factor-β signaling in liver metastasis of colon cancer

(2009) Bixiang Zhang et al.   CANCER LETTERS

Targeting transforming growth factor (TGF)-βRI inhibits activation of β1 integrin and blocks vascular invasion in hepatocellular carcinoma

(2009) Emilia Fransvea et al.   HEPATOLOGY

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

(2009) Andrew R Reynolds et al.   NATURE MEDICINE

Sorafenib for the Treatment of Unresectable Hepatocellular Carcinoma

(2009) R. C. Kane et al.   ONCOLOGIST

Recombinant CBD–HepII polypeptide of fibronectin inhibits αvβ3 signaling and hematogenous metastasis of tumor

(2008) Wei Gong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cooperation between integrin  5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity

(2008) S. Choi et al.   BLOOD

TGF- receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-1 in myelo-monocytic leukaemic cells co-cultured with stromal cells

(2008) Yuanyuan Xu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds  5 1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study

(2008) A. D. Ricart et al.   CLINICAL CANCER RESEARCH

Proapoptotic Function of Integrin  3 in Human Hepatocellular Carcinoma Cells

(2008) Y. Wu et al.   CLINICAL CANCER RESEARCH

βig-h3 Interacts with α3β1 Integrin to Promote Adhesion and Migration of Human Hepatoma Cells

(2008) Juan Tang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Laminin α5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule

(2008) Yamato Kikkawa et al.   EXPERIMENTAL CELL RESEARCH

Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells

(2008) Emilia Fransvea et al.   HEPATOLOGY

Integrin α5-induced EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway

(2008) Ziqiu Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phase I Clinical Trial of Cilengitide in Children With Refractory Brain Tumors: Pediatric Brain Tumor Consortium Study PBTC-012

(2008) Tobey J. MacDonald et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme

(2008) David A. Reardon et al.   JOURNAL OF CLINICAL ONCOLOGY

Anti-integrin monoclonal antibody CNTO 95 enhances the therapeutic efficacy of fractionated radiation therapy in vivo

(2008) Shoucheng Ning et al.   MOLECULAR CANCER THERAPEUTICS

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE