Human CARD9: A Critical Molecule of Fungal Immune Surveillance

Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts

(2018) Michail S. Lionakis et al.   Annual Review of Immunology

GM-CSF therapy in human caspase recruitment domain–containing protein 9 deficiency

(2018) Rebecca A. Drummond et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prototheca zopfii Colitis in Inherited CARD9 Deficiency

(2018) Sinan Sari et al.   JOURNAL OF INFECTIOUS DISEASES

Impaired Specific Antifungal Immunity in CARD9-Deficient Patients with Phaeohyphomycosis

(2018) Xiaowen Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses

(2018) Xia Xu et al.   NATURE IMMUNOLOGY

Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence

(2017) Bruno Lamas et al.   GUT

Syk inhibitors in clinical development for hematological malignancies

(2017) Delong Liu et al.   Journal of Hematology & Oncology

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

(2017) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired RASGRF1/ERK–mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians

(2016) Christina Gavino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye

(2016) Ellen J. Lee et al.   JOURNAL OF IMMUNOLOGY

PKC-δ activation in neutrophils promotes fungal clearance

(2016) Xun Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Impairment of Immune Response against Dematiaceous Fungi in Card9 Knockout Mice

(2016) Weiwei Wu et al.   MYCOPATHOLOGIA

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Successful Granulocyte Colony-stimulating Factor Treatment of Relapsing Candida albicans Meningoencephalitis Caused by CARD9 Deficiency

(2016) Fatih Celmeli et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

(2016) Tamás Németh et al.   Nature Communications

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity

(2016) Susanne Roth et al.   Cell Reports

Mechanistic Insights into the Role of C-Type Lectin Receptor/CARD9 Signaling in Human Antifungal Immunity

(2016) Rebecca A. Drummond et al.   Frontiers in Cellular and Infection Microbiology

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

(2015) R. Flynn et al.   BLOOD

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation

(2015) Zhifang Cao et al.   IMMUNITY

Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both

(2015) Fanny Lanternier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CARD9 Deficiencies Linked to Impaired Neutrophil Functions Against Phialophora verrucosa

(2015) Pin Liang et al.   MYCOPATHOLOGIA

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

(2015) Anupam Jhingran et al.   PLoS Pathogens

CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System

(2015) Rebecca A. Drummond et al.   PLoS Pathogens

Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects

(2014) R. P. Gazendam et al.   BLOOD

Tumor cell-activated CARD9 signaling contributes to metastasis-associated macrophage polarization

(2014) M Yang et al.   CELL DEATH AND DIFFERENTIATION

Rapid CD4+T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9

(2014) Shaikh M. Atif et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Defect of CARD9 Leads to Impaired Accumulation of Gamma Interferon-Producing Memory Phenotype T Cells in Lungs and Increased Susceptibility to Pulmonary Infection with Cryptococcus neoformans

(2014) Hideki Yamamoto et al.   INFECTION AND IMMUNITY

CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity

(2014) Xin-Ming Jia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

(2014) Krzysztof Kiryluk et al.   NATURE GENETICS

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production

(2014) Susanne Roth et al.   NATURE IMMUNOLOGY

Mendelian Genetics of Human Susceptibility to Fungal Infection

(2014) M. S. Lionakis et al.   Cold Spring Harbor Perspectives in Medicine

Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency

(2013) A. Drewniak et al.   BLOOD

Hyperactivated JNK Is a Therapeutic Target in pVHL-Deficient Renal Cell Carcinoma

(2013) J. An et al.   CANCER RESEARCH

Card9 Mediates Intestinal Epithelial Cell Restitution, T-Helper 17 Responses, and Control of Bacterial Infection in Mice

(2013) Harry Sokol et al.   GASTROENTEROLOGY

The Adaptor CARD9 Is Required for Adaptive but Not Innate Immunity to Oral Mucosal Candida albicans Infections

(2013) Shrinivas Bishu et al.   INFECTION AND IMMUNITY

CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies

(2013) Xiaowen Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deep Dermatophytosis and Inherited CARD9 Deficiency

(2013) Fanny Lanternier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

(2013) Mélissa Beaudoin et al.   PLoS Genetics

Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes

(2013) Slavé Petrovski et al.   PLoS Genetics

The Autophagy Regulator Rubicon Is a Feedback Inhibitor of CARD9-Mediated Host Innate Immunity

(2012) Chul-Su Yang et al.   Cell Host & Microbe

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9

(2011) Marcel Janse et al.   HEPATOLOGY

Genetic Variation in the Dectin-1/CARD9 Recognition Pathway and Susceptibility to Candidemia

(2011) Diana C. Rosentul et al.   JOURNAL OF INFECTIOUS DISEASES

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

(2010) Rebecca A. Drummond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene

(2010) J J Pointon et al.   GENES AND IMMUNITY

The adaptor molecule CARD9 is essential for tuberculosis control

(2010) Anca Dorhoi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE