MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

MALT1 is not alone after all: identification of novel paracaspases

(2015) Paco Hulpiau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MALT1 - a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

(2015) Inna S. Afonina et al.   FEBS Journal

The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination

(2015) Lynn Elton et al.   IMMUNOLOGICAL REVIEWS

Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation

(2015) Divya Punwani et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

(2015) Frédéric Bornancin et al.   JOURNAL OF IMMUNOLOGY

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

(2015) Jong W. Yu et al.   PLoS One

An E3 ubiquitin ligase-independent role of LUBAC

(2014) R. Beyaert   BLOOD

A catalytic-independent role for the LUBAC in NF- B activation upon antigen receptor engagement and in lymphoma cells

(2014) S. M. Dubois et al.   BLOOD

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity

(2014) Maike Jaworski et al.   EMBO JOURNAL

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

(2014) Conor Mc Guire et al.   Journal of Neuroinflammation

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

(2014) Katharina M Jeltsch et al.   NATURE IMMUNOLOGY

MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes

(2014) Mathijs Baens et al.   PLoS One

Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation

(2014) Andreas Gewies et al.   Cell Reports

Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

(2013) Takuya Uehata et al.   CELL

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency

(2013) Haifa H. Jabara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Combined immunodeficiency associated with homozygous MALT1 mutations

(2013) Margaret L. McKinnon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements

(2013) Judith J. Smit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paracaspase MALT1 Deficiency Protects Mice from Autoimmune-Mediated Demyelination

(2013) C. Mc Guire et al.   JOURNAL OF IMMUNOLOGY

Mechanism and specificity of the human paracaspase MALT1

(2012) Janna Hachmann et al.   BIOCHEMICAL JOURNAL

MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

(2012) Lorena Fontan et al.   CANCER CELL

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

(2012) Benjamin Stieglitz et al.   EMBO REPORTS

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells

(2012) Anne Brüstle et al.   JOURNAL OF CLINICAL INVESTIGATION

Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not

(2011) Kelly Verhelst et al.   BIOCHEMICAL PHARMACOLOGY

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

Autoregulation of Parkin activity through its ubiquitin-like domain

(2011) Viduth K Chaugule et al.   EMBO JOURNAL

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

(2011) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage by MALT1 induces cytosolic release of A20

(2010) Claire Malinverni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NF-κB signaling pathways regulated by CARMA family of scaffold proteins

(2010) Marzenna Blonska et al.   CELL RESEARCH

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

(2009) Uta Ferch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY