From MALT lymphoma to the CBM signalosome

CARMA3 is Crucial for EGFR-Induced Activation of NF- B and Tumor Progression

(2011) T. Jiang et al.   CANCER RESEARCH

B cell antigen receptor-induced activation of an IRAK4-dependent signaling pathway revealed by a MALT1-IRAK4 double knockout mouse model

(2011) Almut Dufner et al.   Cell Communication and Signaling

A20, ABIN-1/2, and CARD11 Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma

(2011) Gehong Dong et al.   CLINICAL CANCER RESEARCH

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

MALT lymphoma: many roads lead to nuclear factor-κb activation

(2011) Ming-Qing Du   HISTOPATHOLOGY

The Ca2+-dependent Phosphatase Calcineurin Controls the Formation of the Carma1-Bcl10-Malt1 Complex during T Cell Receptor-induced NF-κB Activation

(2011) Lysann Palkowitsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB

(2011) Sreenivasa Rao Oruganti et al.   MOLECULAR IMMUNOLOGY

Cleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF- B Activation

(2011) S. Rosebeck et al.   SCIENCE

Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2

(2011) Sonja I. Gringhuis et al.   PLoS Pathogens

Cleavage by MALT1 induces cytosolic release of A20

(2010) Claire Malinverni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncogenic CARD11 Mutations Induce Hyperactive Signaling by Disrupting Autoinhibition by the PKC-Responsive Inhibitory Domain

(2010) Rebecca L. Lamason et al.   BIOCHEMISTRY

NF-κB signaling pathways regulated by CARMA family of scaffold proteins

(2010) Marzenna Blonska et al.   CELL RESEARCH

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

(2010) Andrea C Eitelhuber et al.   EMBO JOURNAL

The CARMA3-Bcl10-MALT1 Signalosome Promotes Angiotensin II-dependent Vascular Inflammation and Atherogenesis

(2010) Linda M. McAllister-Lucas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin-dependent NF-κB Activation and Monocyte/Endothelial Adhesion Are Mediated by the CARMA3·Bcl10·MALT1 Signalosome

(2010) Phillip C. Delekta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

Critical role of PI3K signaling for NF- B-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells

(2010) B. Kloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCL12/SDF‐1α Activates NF‐κB and Promotes Oral Cancer Invasion through the Carma3/Bcl10/Malt1 Complex

(2010) Aasia O Rehman et al.   International Journal of Oral Science

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

(2009) K. Honma et al.   BLOOD

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

ADAM-mediated amphiregulin shedding and EGFR transactivation

(2009) S. Kasina et al.   CELL PROLIFERATION

Platelet-activating factor-induced NF-κB activation and IL-8 production in intestinal epithelial cells are Bcl10-dependent

(2009) Alip Borthakur et al.   INFLAMMATORY BOWEL DISEASES

Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets

(2009) Michael W. Tusche et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

(2009) Uta Ferch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival

(2009) Nicolas Bidère et al.   NATURE

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma

(2009) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of CARMA1 by HPK1 is critical for NF- B activation in T cells

(2009) D. Brenner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CARMA3 Mediates Lysophosphatidic Acid–Stimulated Cytokine Secretion by Bronchial Epithelial Cells

(2008) Benjamin D. Medoff et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF- B and MAPK activation to selectively control cytokine production

(2008) O. Gross et al.   BLOOD

Mucosa-Associated Lymphoid Tissue Lymphoma: Novel Translocations Including Rearrangements of ODZ2, JMJD2C, and CNN3

(2008) U. Vinatzer et al.   CLINICAL CANCER RESEARCH

CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NFκB through the CBM (Carma3/Bcl10/Malt1) Complex

(2008) Daniel Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

(2008) G. Lenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

(2008) G. Lenz et al.   SCIENCE