Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2–MALT1 in MALT lymphoma

Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma

(2013) S. R. P. McDonnell et al.   BLOOD

Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

(2013) Takuya Uehata et al.   CELL

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

Mechanism and specificity of the human paracaspase MALT1

(2012) Janna Hachmann et al.   BIOCHEMICAL JOURNAL

MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

(2012) Lorena Fontan et al.   CANCER CELL

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition

(2012) Shumin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants of MALT1 Protease Activity

(2012) Christian Wiesmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

(2012) Luca Busino et al.   NATURE CELL BIOLOGY

Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice

(2012) C. Vicente-Duenas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

(2011) J. Chad Brenner et al.   CANCER CELL

From MALT lymphoma to the CBM signalosome

(2011) Shaun Rosebeck et al.   CELL CYCLE

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis

(2011) S R P McDonnell et al.   ONCOGENE

Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

(2011) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region

(2011) J. W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF- B Activation

(2011) S. Rosebeck et al.   SCIENCE

Epithelial Protein Lost in Neoplasm α (Eplin-α) is transcriptionally regulated by G-actin and MAL/MRTF coactivators

(2010) Laura Leitner et al.   Molecular Cancer

Integrative genomics identifies LMO1 as a neuroblastoma oncogene

(2010) Kai Wang et al.   NATURE

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

(2010) M. P. McCormack et al.   SCIENCE

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

(2009) Uta Ferch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma

(2009) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution array comparative genomic hybridization analysis of human bronchial and salivary adenoid cystic carcinoma

(2008) Alain Bernheim et al.   LABORATORY INVESTIGATION

Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome

(2008) Wen G Jiang et al.   Molecular Cancer

Finally, MALT1 is a protease!

(2008) Linda M McAllister-Lucas et al.   NATURE IMMUNOLOGY

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE