γδ T cells and epigenetic drugs: A useful merger in cancer immunotherapy?

Valproic Acid Upregulates NKG2D Ligand Expression through an ERK-dependent Mechanism and Potentially Enhances NK Cell-mediated Lysis of Myeloma

(2015) Xiaosong Wu et al.   NEOPLASIA

Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway

(2014) Pengfei Shi et al.   BMC CANCER

Novel Bispecific Antibodies Increase    T-Cell Cytotoxicity against Pancreatic Cancer Cells

(2014) H.-H. Oberg et al.   CANCER RESEARCH

Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies

(2014) D. C. Deniger et al.   CLINICAL CANCER RESEARCH

Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia

(2014) A Baragaño Raneros et al.   GENES AND IMMUNITY

Histone Deacetylase Inhibitors Modulate Interleukin 6-dependent CD4+T Cell Polarizationin Vitroandin Vivo

(2014) Rainer Glauben et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

A Phase II Clinical Trial of Oral Valproic Acid in Patients with Castration-Resistant Prostate Cancers Using an Intensive Biomarker Sampling Strategy

(2014) Sunil Sharma et al.   Translational Oncology

γδ T cells for cancer immunotherapy

(2014) Jonathan PH Fisher et al.   OncoImmunology

Regulation of mevalonate metabolism in cancer and immune cells

(2013) Martin Thurnher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions

(2013) M. Zilbauer et al.   BLOOD

Neutrophil uptake of nitrogen-bisphosphonates leads to the suppression of human peripheral blood γδ T cells

(2013) Shirin Kalyan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendants

(2013) Maria Alessandra Vigano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: Heterogeneous involvement of the “a disintegrin and metalloproteases” 10 and 17

(2013) Guranda Chitadze et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets

(2013) Nina Schmolka et al.   NATURE IMMUNOLOGY

Generation of Soluble NKG2D Ligands: Proteolytic Cleavage, Exosome Secretion and Functional Implications

(2013) G. Chitadze et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

(2013) Metin Karahoca et al.   Clinical Epigenetics

Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity

(2013) Dieter Kabelitz et al.   OncoImmunology

Combining conventional chemotherapy and γδ T cell-based immunotherapy to target cancer-initiating cells

(2013) Matilde Todaro et al.   OncoImmunology

Epigenetic Therapy of Non-Small Cell Lung Cancer Using Decitabine (5-Aza-2′-Deoxycytidine)

(2013) Richard L. Momparler   Frontiers in Oncology

Maturation-related histone modifications in the PU.1 promoter regulate Th9-cell development

(2012) A. Ramming et al.   BLOOD

Phase I study of 5-aza-2′-deoxycytidine in combination with valproic acid in non-small-cell lung cancer

(2012) B. F. Chu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8+T and NK cells

(2012) Alba Fernández-Sánchez et al.   Epigenetics

Tumor-promoting Versus Tumor-antagonizing Roles of γδ T Cells in Cancer Immunotherapy

(2012) Volker Kunzmann et al.   JOURNAL OF IMMUNOTHERAPY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models

(2012) Li Shen et al.   PLoS One

Anti-leukemia activity of human gamma delta T cells

(2012) Gabrielle M. Siegers   OncoImmunology

Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours

(2011) A J Nicol et al.   BRITISH JOURNAL OF CANCER

Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma

(2011) Joshua M. Lang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antitumor activities of valproic acid on Epstein-Barr virus-associated T and natural killer lymphoma cells

(2011) Seiko Iwata et al.   CANCER SCIENCE

A 5-aza-2'-deoxycytidine/valproate combination induces cytotoxic T-cell response against mesothelioma

(2011) S. Leclercq et al.   EUROPEAN RESPIRATORY JOURNAL

Upregulation of NKG2D ligands and enhanced natural killer cell cytotoxicity by hydralazine and valproate

(2011) A. Due�as-Gonz�lez   INTERNATIONAL JOURNAL OF ONCOLOGY

A Pilot Phase II Study of Valproic Acid for Treatment of Low-Grade Neuroendocrine Carcinoma

(2011) T. A. Mohammed et al.   ONCOLOGIST

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

(2010) Michael Schnekenburger et al.   BIOCHEMICAL PHARMACOLOGY

A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells☆☆☆

(2010) Jun Nakajima et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity

(2010) Yamanegi   ONCOLOGY REPORTS

Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies

(2009) J. Gertner-Dardenne et al.   BLOOD

Antitumor Activity of    T Cells Reactive against Cytomegalovirus-Infected Cells in a Mouse Xenograft Tumor Model

(2009) C. Devaud et al.   CANCER RESEARCH

Epigenetic Therapy: Histone Acetylation, DNA Methylation and Anti-Cancer Drug Discovery

(2009) A. Ganesan et al.   CURRENT CANCER DRUG TARGETS

Clinical and immunological evaluation of zoledronate-activated Vγ9γδ T-cell-based immunotherapy for patients with multiple myeloma

(2009) Yu Abe et al.   EXPERIMENTAL HEMATOLOGY

Genome-wide Analysis of Histone Methylation Reveals Chromatin State-Based Regulation of Gene Transcription and Function of Memory CD8+ T Cells

(2009) Yasuto Araki et al.   IMMUNITY

Zoledronate facilitates large-scale ex vivo expansion of functional γδ T cells from cancer patients for use in adoptive immunotherapy*

(2008) M. Kondo et al.   CYTOTHERAPY