Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase

Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis

(2013) Libor Macurek et al.   CELL CYCLE

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

(2013) S. Kumar et al.   GENES & DEVELOPMENT

The Preference for Error-Free or Error-Prone Postreplication Repair in Saccharomyces cerevisiae Exposed to Low-Dose Methyl Methanesulfonate Is Cell Cycle Dependent

(2013) D. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

(2013) Joon Lee et al.   MOLECULAR BIOLOGY OF THE CELL

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

(2013) Anja M. Duursma et al.   MOLECULAR CELL

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling

(2013) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Response to DNA damage: why do we need to focus on protein phosphatases?

(2013) Midori Shimada et al.   Frontiers in Oncology

An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control

(2012) Hannah C Cheung et al.   BMC GENOMICS

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

(2012) Jiazhi Hu et al.   CELL

Mcm10 Plays a Role in Functioning of the Eukaryotic Replicative DNA Helicase, Cdc45-Mcm-GINS

(2012) George Watase et al.   CURRENT BIOLOGY

Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components

(2012) Mai Kanke et al.   EMBO JOURNAL

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

(2012) Anna Maria Hegnauer et al.   EMBO JOURNAL

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

(2012) Frederick van Deursen et al.   EMBO JOURNAL

Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes

(2012) Francisco M Bastos de Oliveira et al.   EMBO JOURNAL

DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1

(2012) Anna Travesa et al.   EMBO JOURNAL

dNTP pools determine fork progression and origin usage under replication stress

(2012) Jérôme Poli et al.   EMBO JOURNAL

Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair

(2012) Xinxin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Saccharomyces cerevisiae Chromatin Remodeler Fun30 Regulates DNA End Resection and Checkpoint Deactivation

(2012) V. V. Eapen et al.   MOLECULAR AND CELLULAR BIOLOGY

G1/S and G2/M Cyclin-Dependent Kinase Activities Commit Cells to Death in the Absence of the S-Phase Checkpoint

(2012) N. Manfrini et al.   MOLECULAR AND CELLULAR BIOLOGY

Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo

(2012) Theresa J. Berens et al.   MOLECULAR BIOLOGY OF THE CELL

Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart

(2012) Mireille Tittel-Elmer et al.   MOLECULAR CELL

Replisome Stability at Defective DNA Replication Forks Is Independent of S Phase Checkpoint Kinases

(2012) Giacomo De Piccoli et al.   MOLECULAR CELL

Noncanonical Role of the 9-1-1 Clamp in the Error-Free DNA Damage Tolerance Pathway

(2012) Georgios Ioannis Karras et al.   MOLECULAR CELL

Dissection of DNA Damage Responses Using Multiconditional Genetic Interaction Maps

(2012) Aude Guénolé et al.   MOLECULAR CELL

DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9

(2012) Patrice Y. Ohouo et al.   NATURE

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

(2012) Thomas Costelloe et al.   NATURE

The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends

(2012) Xuefeng Chen et al.   NATURE

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

(2012) S. Liu et al.   NUCLEIC ACIDS RESEARCH

Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex

(2012) I. Ilves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner

(2012) Su-Jiun Lin et al.   PLoS Genetics

Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase

(2011) Vasundhara M. Navadgi-Patil et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

(2011) Rodrigo Bermejo et al.   CELL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Origin Association of Sld3, Sld7, and Cdc45 Proteins Is a Key Step for Determination of Origin-Firing Timing

(2011) Seiji Tanaka et al.   CURRENT BIOLOGY

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin

(2011) ManTek Yeung et al.   DNA REPAIR

DNA end resection—Unraveling the tail

(2011) Eleni P. Mimitou et al.   DNA REPAIR

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

(2011) Boris Pfander et al.   EMBO JOURNAL

Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast

(2011) Davide Mantiero et al.   EMBO JOURNAL

The effect of the intra-S-phase checkpoint on origins of replication in human cells

(2011) Neerja Karnani et al.   GENES & DEVELOPMENT

The Phosphorylation Network for Efficient Activation of the DNA Replication Checkpoint in Fission Yeast

(2011) Ming Yue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Greatwall and Polo-like Kinase 1 Coordinate to Promote Checkpoint Recovery

(2011) Aimin Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hMSH2 Recruits ATR to DNA Damage Sites for Activation during DNA Damage-induced Apoptosis

(2011) Navjotsingh Pabla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unstructured C-terminal Tail of Yeast Dpb11 (Human TopBP1) Protein Is Dispensable for DNA Replication and the S Phase Checkpoint but Required for the G2/M Checkpoint

(2011) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase

(2011) Edward A. Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair

(2011) Shaun E. Peterson et al.   JOURNAL OF CELL BIOLOGY

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

(2011) Marie Regairaz et al.   JOURNAL OF CELL BIOLOGY

WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes

(2011) B. S. Patro et al.   JOURNAL OF CELL SCIENCE

ATP-Dependent Chromatin Remodeling Factors Tune S Phase Checkpoint Activity

(2011) T. J. Au et al.   MOLECULAR AND CELLULAR BIOLOGY

Plk1 Phosphorylation of Orc2 Promotes DNA Replication under Conditions of Stress

(2011) B. Song et al.   MOLECULAR AND CELLULAR BIOLOGY

ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation

(2011) Shizhou Liu et al.   MOLECULAR CELL

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

(2011) C. S. Sorensen et al.   NUCLEIC ACIDS RESEARCH

Human RAD18 Interacts with Ubiquitylated Chromatin Components and Facilitates RAD9 Recruitment to DNA Double Strand Breaks

(2011) Akiko Inagaki et al.   PLoS One

ATR-p53 Restricts Homologous Recombination in Response to Replicative Stress but Does Not Limit DNA Interstrand Crosslink Repair in Lung Cancer Cells

(2011) Bianca M. Sirbu et al.   PLoS One

Sensing of Replication Stress and Mec1 Activation Act through Two Independent Pathways Involving the 9-1-1 Complex and DNA Polymerase ε

(2011) Fabio Puddu et al.   PLoS Genetics

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

(2011) Melanie Blasius et al.   GENOME BIOLOGY

Phosphatases in the cellular response to DNA damage

(2010) Alyson K Freeman et al.   Cell Communication and Signaling

Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation

(2010) Thomas Schleker et al.   CELL CYCLE

The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

(2010) Richard Hill et al.   CELL CYCLE

Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast

(2010) Seiji Matsumoto et al.   CELL CYCLE

Regulation of the initiation step of DNA replication by cyclin-dependent kinases

(2010) Seiji Tanaka et al.   CHROMOSOMA

Replication Origins and Timing of Temporal Replication in Budding Yeast: How to Solve the Conundrum?

(2010) Matteo Barberis et al.   CURRENT GENOMICS

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

(2010) Francesca Ammazzalorso et al.   EMBO JOURNAL

A Proteome-wide Analysis of Kinase-Substrate Network in the DNA Damage Response

(2010) Sheng-hong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

DDK Phosphorylates Checkpoint Clamp Component Rad9 and Promotes Its Release from Damaged Chromatin

(2010) Kanji Furuya et al.   MOLECULAR CELL

DNA Damage Signaling Recruits the Rtt107-Slx4 Scaffolds via Dpb11 to Mediate Replication Stress Response

(2010) Patrice Y. Ohouo et al.   MOLECULAR CELL

Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

(2010) John C.W. Randell et al.   MOLECULAR CELL

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

Damage-induced phosphorylation of Sld3 is important to block late origin firing

(2010) Jaime Lopez-Mosqueda et al.   NATURE

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

(2010) Philip Zegerman et al.   NATURE

Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response

(2010) Laure Crabbé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CDC5 Inhibits the Hyperphosphorylation of the Checkpoint Kinase Rad53, Leading to Checkpoint Adaptation

(2010) Genevieve M. Vidanes et al.   PLOS BIOLOGY

A Kinase-Independent Role for the Rad3ATR-Rad26ATRIP Complex in Recruitment of Tel1ATM to Telomeres in Fission Yeast

(2010) Lakxmi Subramanian et al.   PLoS Genetics

Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling Pathway

(2010) Roberto Antonio Donnianni et al.   PLoS Genetics

DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress

(2009) V. Leung-Pineda et al.   CANCER RESEARCH

Replicon Dynamics, Dormant Origin Firing, and Terminal Fork Integrity after Double-Strand Break Formation

(2009) Ylli Doksani et al.   CELL

ATR/Mec1: coordinating fork stability and repair

(2009) Anna M Friedel et al.   CURRENT OPINION IN CELL BIOLOGY

DNA damage checkpoint inactivation: Adaptation and recovery

(2009) Céline Clémenson et al.   DNA REPAIR

DNA replication as a target of the DNA damage checkpoint

(2009) Philip Zegerman et al.   DNA REPAIR

Rad52 recruitment is DNA replication independent and regulated by Cdc28 and the Mec1 kinase

(2009) Jacqueline H Barlow et al.   EMBO JOURNAL

The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells

(2009) Erwan Watrin et al.   EMBO JOURNAL

The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress

(2009) Mireille Tittel-Elmer et al.   EMBO JOURNAL

Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpoint

(2009) Constance Alabert et al.   EMBO JOURNAL

A recombination execution checkpoint regulates the choice of homologous recombination pathway during DNA double-strand break repair

(2009) S. Jain et al.   GENES & DEVELOPMENT

Long Patch Base Excision Repair Proceeds via Coordinated Stimulation of the Multienzyme DNA Repair Complex

(2009) Lata Balakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway

(2009) Yiyong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of Rad53 Activation by Mec1 through Adaptor Protein Mrc1

(2009) Sheng-hong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Csm3, Tof1, and Mrc1 Form a Heterotrimeric Mediator Complex That Associates with DNA Replication Forks

(2009) Masashige Bando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin

(2009) Helene Faustrup et al.   JOURNAL OF CELL BIOLOGY

The Direct Binding of Mrc1, a Checkpoint Mediator, to Mcm6, a Replication Helicase, Is Essential for the Replication Checkpoint against Methyl Methanesulfonate-Induced Stress

(2009) M. Komata et al.   MOLECULAR AND CELLULAR BIOLOGY

Dephosphorylation of  H2A by Glc7/Protein Phosphatase 1 Promotes Recovery from Inhibition of DNA Replication

(2009) M. Bazzi et al.   MOLECULAR AND CELLULAR BIOLOGY

Maintenance of the DNA-Damage Checkpoint Requires DNA-Damage-Induced Mediator Protein Oligomerization

(2009) Takehiko Usui et al.   MOLECULAR CELL

The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms

(2009) Vasundhara M. Navadgi-Patil et al.   MOLECULAR CELL

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae

(2009) Anna Azvolinsky et al.   MOLECULAR CELL

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

(2009) You-Wei Zhang et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

(2009) Matilde Murga et al.   NATURE GENETICS

A Flp-nick system to study repair of a single protein-bound nick in vivo

(2009) Ida Nielsen et al.   NATURE METHODS

Involvement of a chromatin remodeling complex in damage tolerance during DNA replication

(2009) Karina B Falbo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork

(2009) M. L. Naylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress

(2009) Katie Myers et al.   PLoS Genetics

Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

(2008) Samuel Sidi et al.   CELL

Rad6-Rad18 Mediates a Eukaryotic SOS Response by Ubiquitinating the 9-1-1 Checkpoint Clamp

(2008) Yu Fu et al.   CELL

Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

(2008) Markus Räschle et al.   CELL

Ino80 Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks

(2008) Kenji Shimada et al.   CURRENT BIOLOGY

Multiple pathways cooperate to facilitate DNA replication fork progression through alkylated DNA

(2008) M VAZQUEZ et al.   DNA REPAIR

Plx1 is required for chromosomal DNA replication under stressful conditions

(2008) Kristina Trenz et al.   EMBO JOURNAL

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

(2008) Isabelle Morin et al.   EMBO JOURNAL

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks

(2008) M. Segurado et al.   GENES & DEVELOPMENT

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae

(2008) S. J. Szyjka et al.   GENES & DEVELOPMENT

Functional Interactions Between Sae2 and the Mre11 Complex

(2008) H.-S. Kim et al.   GENETICS

Phosphorylation of the Budding Yeast 9-1-1 Complex Is Required for Dpb11 Function in the Full Activation of the UV-Induced DNA Damage Checkpoint

(2008) F. Puddu et al.   MOLECULAR AND CELLULAR BIOLOGY

Minichromosome Maintenance Proteins Interact with Checkpoint and Recombination Proteins To Promote S-Phase Genome Stability

(2008) J. M. Bailis et al.   MOLECULAR AND CELLULAR BIOLOGY

Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins

(2008) Min Huang et al.   MOLECULAR CANCER THERAPEUTICS

The Role of Dbf4/Drf1-Dependent Kinase Cdc7 in DNA-Damage Checkpoint Control

(2008) Toshiya Tsuji et al.   MOLECULAR CELL

Dif1 Is a DNA-Damage-Regulated Facilitator of Nuclear Import for Ribonucleotide Reductase

(2008) Yang David Lee et al.   MOLECULAR CELL

Colocalization of Sensors Is Sufficient to Activate the DNA Damage Checkpoint in the Absence of Damage

(2008) Carla Yaneth Bonilla et al.   MOLECULAR CELL

Mrc1 and DNA Polymerase ɛ Function Together in Linking DNA Replication and the S Phase Checkpoint

(2008) Huiqiang Lou et al.   MOLECULAR CELL

RAD6–RAD18–RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

(2008) Takashi Hishida et al.   NATURE

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATP-dependent chromatin remodeling shapes the DNA replication landscape

(2008) Jack A Vincent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Ino80 chromatin-remodeling enzyme regulates replisome function and stability

(2008) Manolis Papamichos-Chronakis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dpb11 activates the Mec1-Ddc2 complex

(2008) D. A. Mordes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1

(2008) R. A. M. de Bruin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE