Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis

Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

(2012) Pavel Moudry et al.   CELL CYCLE

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Protein phosphatases and the dynamics of the DNA damage response

(2011) Dennis R. Harris et al.   CELL CYCLE

Give me a break, but not in mitosis

(2011) Simona Giunta et al.   CELL CYCLE

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

(2011) Martin Kosar et al.   CELL CYCLE

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint

(2011) Chunying Yang et al.   MOLECULAR CELL

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

(2011) Philip M Reaper et al.   Nature Chemical Biology

ELM--the database of eukaryotic linear motifs

(2011) H. Dinkel et al.   NUCLEIC ACIDS RESEARCH

Oncogenic Wip1 Phosphatase Is Inhibited by miR-16 in the DNA Damage Signaling Pathway

(2010) X. Zhang et al.   CANCER RESEARCH

Wip1 Directly Dephosphorylates  -H2AX and Attenuates the DNA Damage Response

(2010) H. Cha et al.   CANCER RESEARCH

Dephosphorylation of γ-H2AX by WIP1: An important homeostatic regulatory event in DNA repair and cell cycle control

(2010) Sung-Hwan Moon et al.   CELL CYCLE

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling

(2010) Sona Hubackova et al.   CELL CYCLE

Expression of a Homeostatic Regulator, Wip1 (Wild-type p53-induced Phosphatase), Is Temporally Induced by c-Jun and p53 in Response to UV Irradiation

(2010) Ji-young Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair

(2010) Sung-Hwan Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage signaling in response to double-strand breaks during mitosis

(2010) Simona Giunta et al.   JOURNAL OF CELL BIOLOGY

Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition

(2010) L Macůrek et al.   ONCOGENE

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas

(2009) D. S.P. Tan et al.   CLINICAL CANCER RESEARCH

Control of cell growth by the SCF and APC/C ubiquitin ligases

(2009) Jeffrey R Skaar et al.   CURRENT OPINION IN CELL BIOLOGY

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression

(2009) Arne Lindqvist et al.   EMBO JOURNAL

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

(2009) Simon Bekker-Jensen et al.   NATURE CELL BIOLOGY

Wip1 Regulates the Generation of New Neural Cells in the Adult Olfactory Bulb through p53-Dependent Cell Cycle Control

(2009) Yun-Hua Zhu et al.   STEM CELLS

WIP1 phosphatase at the crossroads of cancer and aging

(2009) Xavier Le Guezennec et al.   TRENDS IN BIOCHEMICAL SCIENCES

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora

(2008) Eunice H. Y. Chan et al.   CHROMOSOMA

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A

(2008) Rob Wolthuis et al.   MOLECULAR CELL