Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols

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(2018) Francis J. Herman et al.   BRAIN BEHAVIOR AND IMMUNITY

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(2018) Jie Feng et al.   CNS Neuroscience & Therapeutics

Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect

(2018) Yan Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Role of Immunosenescence in Neurodegenerative Diseases

(2018) Erica Costantini et al.   MEDIATORS OF INFLAMMATION

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(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology

(2018) E. Simon et al.   NEUROSCIENCE

Inhibitive Effect of Resveratrol on the Inflammation in Cultured Astrocytes and Microglia Induced by Aβ 1–42

(2018) Haifeng Zhao et al.   NEUROSCIENCE

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: A focus on human studies

(2018) Francesca Pistollato et al.   PHARMACOLOGICAL RESEARCH

Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain

(2018) Francesca L'Episcopo et al.   Frontiers in Aging Neuroscience

Current Concepts of Neurodegenerative Mechanisms in Alzheimer’s Disease

(2018) Kasthuri Bai Magalingam et al.   Biomed Research International

TREM2 R47H Variant as a Risk Factor for Early-Onset Alzheimer's Disease

(2018) Cyril Pottier et al.   JOURNAL OF ALZHEIMERS DISEASE

Examining the impact of grape consumption on brain metabolism and cognitive function in patients with mild decline in cognition: A double-blinded placebo controlled pilot study

(2017) Jooyeon Lee et al.   EXPERIMENTAL GERONTOLOGY

In vivo ROS production and use of oxidative stress-derived biomarkers to detect the onset of diseases such as Alzheimer’s disease, Parkinson’s disease, and diabetes

(2017) Aya Umeno et al.   FREE RADICAL RESEARCH

LRRK2 promotes the activation of NLRC4 inflammasome duringSalmonellaTyphimurium infection

(2017) Weiwei Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

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(2017) Jiao Xue et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

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(2017) Hai-Jiao Liu et al.   Journal of Neuroinflammation

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1

(2017) Peng Zou et al.   Molecular Medicine Reports

A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols

(2017) Lap Ho et al.   MOLECULAR PHARMACEUTICS

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

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(2017) Zhijuan Mao et al.   NEUROCHEMICAL RESEARCH

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2017) Dimitry Ofengeim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial

(2017) Hamish Evans et al.   Nutrients

Resveratrol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage via Inhibition of NLRP3 Inflammasome Activation

(2017) Xiangsheng Zhang et al.   Frontiers in Neuroscience

Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of inflammasome

(2017) Kenji W. Ruiz-Miyazawa et al.   INFLAMMOPHARMACOLOGY

Long-Term Efficacy and Toxicity of Cholinesterase Inhibitors in the Treatment of Alzheimer Disease

(2017) David B Hogan   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

Grape Seed Polyphenolic Extract as a Potential Novel Therapeutic Agent in Tauopathies

(2017) Lap Ho et al.   JOURNAL OF ALZHEIMERS DISEASE

Grape Derived Polyphenols Attenuate Tau Neuropathology in a Mouse Model of Alzheimer's Disease

(2017) Jun Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

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(2016)   Alzheimers & Dementia

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(2016) Simone Lista et al.   Expert Review of Neurotherapeutics

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(2016) Yang Cai et al.   Journal of Neuroinflammation

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(2016) Liang-Mao Chou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

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(2016) Bertrand Fougère et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

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(2016) Pei Zhang et al.   MOVEMENT DISORDERS

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(2016) Ammar Al-Chalabi et al.   Nature Reviews Neurology

Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury

(2016) W Jiang et al.   SPINAL CORD

Effects of grape seed proanthocyanidin on Alzheimer's disease in vitro and in vivo

(2016) Qingwang Lian et al.   Experimental and Therapeutic Medicine

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(2016) Taylor W. Schmitz et al.   Nature Communications

Synaptic degeneration and neurogranin in the pathophysiology of Alzheimer’s disease

(2016) Simone Lista et al.   Expert Review of Neurotherapeutics

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(2016) Khyati Mittal et al.   Scientific Reports

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(2015) Alan King Lun Liu et al.   ACTA NEUROPATHOLOGICA

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(2015) Christian Benedict et al.   Alzheimers & Dementia

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(2015) A. Gustot et al.   BIOCHEMICAL JOURNAL

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(2015) Eirini Lionaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

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(2015) Giulio Maria Pasinetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rifampicin attenuates rotenone-induced inflammation via suppressing NLRP3 inflammasome activation in microglia

(2015) Yanran Liang et al.   BRAIN RESEARCH

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(2015) Charles Bernick et al.   BRITISH JOURNAL OF SPORTS MEDICINE

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(2015) Yiqing Yan et al.   CELL

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(2015) Katherine Kent et al.   EUROPEAN JOURNAL OF NUTRITION

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(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

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(2015) Takuma Misawa et al.   INTERNATIONAL IMMUNOLOGY

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(2015) Jhih-Jia Jhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

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(2015) Ryoichi Takahashi et al.   JOURNAL OF NEUROCHEMISTRY

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(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury

(2015) Yaghoob Farbood et al.   LIFE SCIENCES

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

(2015) Stacy Steinberg et al.   NATURE GENETICS

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(2015) Liuji Chen et al.   NEUROBIOLOGY OF AGING

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(2015) Giuseppe Verdile et al.   NEUROBIOLOGY OF DISEASE

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(2015) R. Scott Turner et al.   NEUROLOGY

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

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(2015) N. Dzamko et al.   NEUROSCIENCE

Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood–brain barrier in AD rats

(2015) H.F. Zhao et al.   NEUROSCIENCE

Grape powder prevents cognitive, behavioral, and biochemical impairments in a rat model of posttraumatic stress disorder

(2015) Naimesh Solanki et al.   NUTRITION RESEARCH

APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

(2014) Daniel M. Michaelson   Alzheimers & Dementia

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(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells

(2014) Haixia Yang et al.   BIOCHEMICAL PHARMACOLOGY

Vascular risk factors and Alzheimer’s disease

(2014) John T O’Brien et al.   BMC Medicine

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease

(2014) Katherine E. Strathearn et al.   BRAIN RESEARCH

Latest treatment options for Alzheimer’s disease, Parkinson’s disease dementia and dementia with Lewy bodies

(2014) Martin Broadstock et al.   EXPERT OPINION ON PHARMACOTHERAPY

Relationship of Collegiate Football Experience and Concussion With Hippocampal Volume and Cognitive Outcomes

(2014) Rashmi Singh et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Procyanidin B2inhibits inflammasome-mediated IL-1β production in lipopolysaccharide-stimulated macrophages

(2014) Neus Martinez-Micaelo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

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(2014) Zhichun Chen et al.   Neuroscience Bulletin

Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients

(2014) Karlijn J Doorn et al.   Acta Neuropathologica Communications

PET Scanning of Brain Tau in Retired National Football League Players: Preliminary Findings

(2013) Gary W. Small et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Therapeutic prospects for Parkinson disease

(2013) C. Warren Olanow et al.   ANNALS OF NEUROLOGY

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

(2013) Huajun Jin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation

(2013) Yanqin Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

(2013) Victoria E. Johnson et al.   BRAIN

R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease

(2013) Isabel Carreras et al.   BRAIN RESEARCH

Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

(2013) Wei Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

(2013) Albino Carrizzo et al.   FOOD AND CHEMICAL TOXICOLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

(2013) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Resveratrol decreases inflammation in the brain of mice with mild traumatic brain injury

(2013) Joshua W. Gatson et al.   Journal of Trauma and Acute Care Surgery

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

The current and projected economic burden of Parkinson's disease in the United States

(2013) Stacey L. Kowal et al.   MOVEMENT DISORDERS

Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation

(2013) Ming Lu et al.   NEUROBIOLOGY OF AGING

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(2013) Heather McCann et al.   PARKINSONISM & RELATED DISORDERS

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Multiclass classification of FDG PET scans for the distinction between Parkinson's disease and atypical parkinsonian syndromes

(2013) Gaëtan Garraux et al.   NeuroImage-Clinical

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease

(2012) Vladimir Coric et al.   ARCHIVES OF NEUROLOGY

The spectrum of disease in chronic traumatic encephalopathy

(2012) Ann C. McKee et al.   BRAIN

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

(2012) Jun Cai et al.   EMBO Molecular Medicine

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

(2012) Zijing Sheng et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Cancer prevention by targeting angiogenesis

(2012) Adriana Albini et al.   Nature Reviews Clinical Oncology

Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease

(2012) Sönke Arlt et al.   NEUROCHEMICAL RESEARCH

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity

(2012) F. Gillardon et al.   NEUROSCIENCE

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

(2012) Beomsue Kim et al.   PLoS One

Mild traumatic brain injury: a risk factor for neurodegeneration

(2012) Brandon E Gavett et al.   Alzheimers Research & Therapy

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Microglia Function in Alzheimer’s Disease

(2012) Egle Solito et al.   Frontiers in Pharmacology

Neuropsychiatric symptoms in Alzheimer’s disease

(2011) Constantine G. Lyketsos et al.   Alzheimers & Dementia

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial

(2011) Sube Banerjee et al.   LANCET

Gallic acid, a histone acetyltransferase inhibitor, suppresses β-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation

(2011) Mi-Jeong Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

GSPE interferes with tau aggregation in vivo: implication for treating tauopathy

(2011) Ismael Santa-Maria et al.   NEUROBIOLOGY OF AGING

Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates

(2011) A. Costanza et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Long-term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy

(2011) Robert A. Stern et al.   PM&R

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(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease

(2010) Mohd.Moshahid Khan et al.   BRAIN RESEARCH

TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy

(2010) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Heterodimerization of Lrrk1–Lrrk2: Implications for LRRK2-associated Parkinson disease

(2010) Justus C. Dachsel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Resveratrol Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity through Its Anti-Inflammatory Actions

(2010) F. Zhang et al.   MOLECULAR PHARMACOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression

(2010) Melissa A. Bradley et al.   NEUROBIOLOGY OF AGING

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice

(2009) Amy M. Hein et al.   BRAIN BEHAVIOR AND IMMUNITY

Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment

(2009) Robert Krikorian et al.   BRITISH JOURNAL OF NUTRITION

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

(2009) Nathan R. Perron et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Rutin Supplementation in the Diet has Protective Effects Against Toxicant-Induced Hippocampal Injury by Suppression of Microglial Activation and Pro-Inflammatory Cytokines

(2009) Tomoko Koda et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

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(2009) Beth E. Snitz   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

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(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Combination therapy with Coenzyme Q10and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s Diseases

(2009) Lichuan Yang et al.   JOURNAL OF NEUROCHEMISTRY

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

(2009) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tart Cherry Juice Decreases Oxidative Stress in Healthy Older Men and Women

(2009) Tinna Traustadóttir et al.   JOURNAL OF NUTRITION

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Role of dopamine receptor agonists in the treatment of early Parkinson's disease

(2009) Ubaldo Bonuccelli et al.   PARKINSONISM & RELATED DISORDERS

Antidepressant-like effect of low molecular proanthocyanidin in mice: Involvement of monoaminergic system

(2009) Ying Xu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Grape Extract Protects Mitochondria from Oxidative Damage and Improves Locomotor Dysfunction and Extends Lifespan in a Drosophila Parkinson's Disease Model

(2009) Jiangang Long et al.   REJUVENATION RESEARCH

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

(2008) Adam S. Fleisher et al.   ARCHIVES OF NEUROLOGY

The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

(2008) Bradford C. Dickerson et al.   CEREBRAL CORTEX

A Pilot Clinical Trial of Creatine and Minocycline in Early Parkinson Disease

(2008)   CLINICAL NEUROPHARMACOLOGY

Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats

(2008) Feng Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Grapes and Human Health: A Perspective

(2008) John M. Pezzuto   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity

(2008) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Grape-Derived Polyphenolics Prevent A  Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

(2008) J. Wang et al.   JOURNAL OF NEUROSCIENCE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

(2007) Genevieve Bureau et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nonmotor symptoms as presenting complaints in Parkinson's disease: A clinicopathological study

(2007) Sean S. O'Sullivan et al.   MOVEMENT DISORDERS

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

(2007) Johanna Ojala et al.   NEUROBIOLOGY OF AGING