Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Inflammasome activation and metabolic disease progression

(2014) Hua-Bing Li et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Downregulation of miR-124 in MPTP-treated mouse model of Parkinson’s disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins

(2014) N. Kanagaraj et al.   NEUROSCIENCE

Metabolic Syndrome: An Important Risk Factor for Parkinson’s Disease

(2014) Pei Zhang et al.   Oxidative Medicine and Cellular Longevity

The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease

(2013) Li Zuo et al.   GENE

The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders

(2013) Elisa Benetti et al.   MEDIATORS OF INFLAMMATION

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease

(2012) Varsha Shukla et al.   ARCHIVES OF MEDICAL RESEARCH

Dangerous Liaisons: Mitochondrial DNA Meets the NLRP3 Inflammasome

(2012) Fabio Martinon   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Cdk5 Protein Inhibition and Aβ42 Increase BACE1 Protein Level in Primary Neurons by a Post-transcriptional Mechanism

(2012) Katherine R. Sadleir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

(2012) E. Hernandez-Cuellar et al.   JOURNAL OF IMMUNOLOGY

Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration

(2012) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

(2011) Alan S. L. Wong et al.   NATURE CELL BIOLOGY

Mitochondrial control of the NLRP3 inflammasome

(2011) Oliver Kepp et al.   NATURE IMMUNOLOGY

Mitochondrial Metabolic Control of Microtubule Dynamics Impairs the Autophagic Pathway in Parkinson’s Disease

(2011) S.M. Cardoso et al.   Neurodegenerative Diseases

Cdk5: Multitasking between physiological and pathological conditions

(2011) Joao P. Lopes et al.   PROGRESS IN NEUROBIOLOGY

Cdk5: a multifaceted kinase in neurodegenerative diseases

(2011) Zelda H. Cheung et al.   TRENDS IN CELL BIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Parkinson's disease tremor-related metabolic network: Characterization, progression, and treatment effects

(2010) Hideo Mure et al.   NEUROIMAGE

GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection

(2010) Y. Xue et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

(2009) Bo Tian et al.   NATURE CELL BIOLOGY

Dopaminergic and Glutamatergic Signaling Crosstalk in Huntington's Disease Neurodegeneration: The Role of p25/Cyclin-Dependent Kinase 5

(2008) P. Paoletti et al.   JOURNAL OF NEUROSCIENCE