Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease
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Title
Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease
Authors
Keywords
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Journal
Frontiers in Neuroscience
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-09-04
DOI
10.3389/fnins.2018.00621
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Note: Only part of the references are listed.- Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
- (2018) Megan F. Duffy et al. Journal of Neuroinflammation
- Neuropathology of Parkinson disease
- (2018) Dennis W. Dickson PARKINSONISM & RELATED DISORDERS
- Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease
- (2017) Lori N. Eidson et al. Journal of Neuroinflammation
- Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models
- (2017) Xiaomin Su et al. MOLECULAR THERAPY
- Animal models of α-synucleinopathy for Parkinson disease drug development
- (2017) James B. Koprich et al. NATURE REVIEWS NEUROSCIENCE
- Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration
- (2017) Itzia Jimenez-Ferrer et al. NEUROBIOLOGY OF DISEASE
- α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration
- (2017) Hisham Abdelmotilib et al. NEUROBIOLOGY OF DISEASE
- The Threshold Theory for Parkinson's Disease
- (2017) Simone Engelender et al. TRENDS IN NEUROSCIENCES
- Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression
- (2017) D. Luke Fischer et al. Scientific Reports
- Cell Biology and Pathophysiology of α-Synuclein
- (2017) Jacqueline Burré et al. Cold Spring Harbor Perspectives in Medicine
- AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease
- (2017) Chi Wang Ip et al. Acta Neuropathologica Communications
- Propagation of pathological α-synuclein in marmoset brain
- (2017) Aki Shimozawa et al. Acta Neuropathologica Communications
- How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?
- (2016) Laura A. Volpicelli-Daley et al. JOURNAL OF NEUROCHEMISTRY
- The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease
- (2016) Matthew J. Benskey et al. JOURNAL OF NEUROCHEMISTRY
- -Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals
- (2016) J. Xu et al. JOURNAL OF NEUROSCIENCE
- Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?
- (2016) Abid Oueslati Journal of Parkinsons Disease
- Post-translational modification of α-synuclein in Parkinson׳s disease
- (2015) Paul J. Barrett et al. BRAIN RESEARCH
- Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
- (2015) Katrina L. Paumier et al. NEUROBIOLOGY OF DISEASE
- Early-onset parkinsonism caused by alpha-synuclein gene triplication: Clinical and genetic findings in a novel family
- (2015) Simone Olgiati et al. PARKINSONISM & RELATED DISORDERS
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
- (2015) Valerie R. Osterberg et al. Cell Reports
- Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease
- (2015) Anke A. Dijkstra et al. PLoS One
- The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity
- (2014) Ossama Khalaf et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
- (2014) Laura A Volpicelli-Daley et al. Nature Protocols
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats
- (2013) Silke Nuber et al. BRAIN
- Cerebrospinal fluid inflammatory markers in Parkinson’s disease – Associations with depression, fatigue, and cognitive impairment
- (2013) Daniel Lindqvist et al. BRAIN BEHAVIOR AND IMMUNITY
- MHCII Is Required for -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration
- (2013) A. S. Harms et al. JOURNAL OF NEUROSCIENCE
- rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
- (2013) Marusela Oliveras-Salvá et al. Molecular Neurodegeneration
- Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
- (2013) Silke Appel-Cresswell et al. MOVEMENT DISORDERS
- Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons
- (2013) Nicholas R. Wall et al. NEURON
- The Function of α-Synuclein
- (2013) Jacob T. Bendor et al. NEURON
- Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System
- (2013) Sara E. Gombash et al. PLoS One
- Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
- (2013) Changyoun Kim et al. Nature Communications
- -Synuclein in Parkinson's Disease
- (2013) L. Stefanis Cold Spring Harbor Perspectives in Medicine
- Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity
- (2012) Meret Nora Gaugler et al. ACTA NEUROPATHOLOGICA
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion
- (2012) Hodaka Yamakado et al. NEUROSCIENCE RESEARCH
- Impaired neurotransmission caused by overexpression of -synuclein in nigral dopamine neurons
- (2012) M. Lundblad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease
- (2011) Jinxia Zhou et al. ACTA NEUROPATHOLOGICA
- Neuropathology underlying clinical variability in patients with synucleinopathies
- (2011) Glenda M. Halliday et al. ACTA NEUROPATHOLOGICA
- Initial neuropsychological impairments in patients with the E46K mutation of the α-synuclein gene (PARK 1)
- (2011) Johanne H. Somme et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
- (2011) M. Decressac et al. NEUROBIOLOGY OF DISEASE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone
- (2011) P. Mulcahy et al. NEUROSCIENCE
- Patterns of alpha-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease
- (2011) Wilma D.J. van de Berg et al. PARKINSONISM & RELATED DISORDERS
- Proteinase K-resistant α-synuclein is deposited in presynapses in human Lewy body disease and A53T α-synuclein transgenic mice
- (2010) Kunikazu Tanji et al. ACTA NEUROPATHOLOGICA
- α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease
- (2010) Pavan K. Auluck et al. Annual Review of Cell and Developmental Biology
- Membrane Interactions of Oligomeric Alpha-Synuclein: Potential Role in Parkinsons Disease
- (2010) Bart D. van Rooijen et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
- (2010) Jia-Yi Li et al. MOVEMENT DISORDERS
- Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease
- (2010) Vanesa Sanchez-Guajardo et al. PLoS One
- Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
- (2009) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Brain α-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation
- (2009) Junchao Tong et al. BRAIN
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV -Synucleinopathy
- (2009) C. Y. Chung et al. JOURNAL OF NEUROSCIENCE
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A critical reappraisal of current staging of Lewy-related pathology in human brain
- (2008) Kurt A. Jellinger ACTA NEUROPATHOLOGICA
- A critical evaluation of the Braak staging scheme for Parkinson's disease
- (2008) Robert E. Burke et al. ANNALS OF NEUROLOGY
- The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of α-synuclein staging
- (2008) M. E. Kalaitzakis et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease
- (2008) Jan Gründemann et al. NUCLEIC ACIDS RESEARCH
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