AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

Alpha-synuclein is associated with the synaptic vesicle apparatus in the human and rat enteric nervous system

(2015) Martina Böttner et al.   BRAIN RESEARCH

Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse

(2015) Lian-Kun Song et al.   PLoS One

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

(2013) Marusela Oliveras-Salvá et al.   Molecular Neurodegeneration

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9

(2011) A Van der Perren et al.   GENE THERAPY

Modelling of Parkinson's disease in mice

(2011) Marie-Françoise Chesselet et al.   LANCET NEUROLOGY

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein

(2011) James B. Koprich et al.   PLoS One

Proteinase K-resistant α-synuclein is deposited in presynapses in human Lewy body disease and A53T α-synuclein transgenic mice

(2010) Kunikazu Tanji et al.   ACTA NEUROPATHOLOGICA

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease

(2010) James B Koprich et al.   Molecular Neurodegeneration

Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease

(2010) Shuwen Cao et al.   Molecular Neurodegeneration

Evaluation of α-synuclein immunohistochemical methods used by invited experts

(2008) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Effects of UCH-L1 on α-synuclein over-expression mouse model of Parkinson’s disease

(2008) Toru Yasuda et al.   JOURNAL OF NEUROCHEMISTRY

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY