Studying Huntington’s Disease in Yeast: From Mechanisms to Pharmacological Approaches

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

TDP-43 controls lysosomal pathways thereby determining its own clearance and cytotoxicity

(2018) Christine Leibiger et al.   HUMAN MOLECULAR GENETICS

The absence of specific yeast heat-shock proteins leads to abnormal aggregation and compromised autophagic clearance of mutant Huntingtin proteins

(2018) Ryan Higgins et al.   PLoS One

Golgi stress response reprograms cysteine metabolism to confer cytoprotection in Huntington’s disease

(2018) Juan I. Sbodio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and structural architecture of polyQ aggregates in yeast

(2018) Anselm Gruber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Huntington's disease: a clinical review

(2017) P. McColgan et al.   EUROPEAN JOURNAL OF NEUROLOGY

Yeast buddies helping to unravel the complexity of neurodegenerative disorders

(2017) Gernot Fruhmann et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Huntington’s Disease and Mitochondria

(2017) Mohammad Jodeiri Farshbaf et al.   NEUROTOXICITY RESEARCH

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

(2017) Eman M. Zaghloul et al.   NUCLEIC ACIDS RESEARCH

Endocytosis regulates TDP-43 toxicity and turnover

(2017) Guangbo Liu et al.   Nature Communications

Green Tea Extracts Epigallocatechin-3-gallate for Different Treatments

(2017) Chenyu Chu et al.   Biomed Research International

Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast

(2017) Lisa L. Berglund et al.   Scientific Reports

Efficient Inhibition of Protein Aggregation, Disintegration of Aggregates, and Lowering of Cytotoxicity by Green Tea Polyphenol-Based Self-Assembled Polymer Nanoparticles

(2016) Koushik Debnath et al.   ACS Applied Materials & Interfaces

RNA toxicity induced by expanded CAG repeats in Huntington's disease

(2016) Eulàlia Martí   BRAIN PATHOLOGY

Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology

(2016) Ying Mao et al.   HUMAN MOLECULAR GENETICS

Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtin

(2016) Kun-Han Chuang et al.   MOLECULAR BIOLOGY OF THE CELL

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

A literature review of flavonoids and lifespan in model organisms

(2016) Kathrin Pallauf et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Polyglutamine toxicity in yeast uncovers phenotypic variations between different fluorescent protein fusions

(2016) Yuwei Jiang et al.   TRAFFIC

CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins

(2016) Ashley A. Zurawel et al.   mBio

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

(2016) Koning Shen et al.   eLife

Glycation potentiates neurodegeneration in models of Huntington’s disease

(2016) Hugo Vicente Miranda et al.   Scientific Reports

Multiple discrete soluble aggregates influence polyglutamine toxicity in a Huntington’s disease model system

(2016) Wen Xi et al.   Scientific Reports

Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects

(2015) Katharina Papsdorf et al.   BMC GENOMICS

Efforts to make and apply humanized yeast

(2015) Jon M. Laurent et al.   Briefings in Functional Genomics

Huntington's disease: An update of therapeutic strategies

(2015) Ashok Kumar et al.   GENE

A plant cell model of polyglutamine aggregation: Identification and characterisation of macromolecular and small-molecule anti-protein aggregation activity in vivo

(2015) Guobao Liu et al.   JOURNAL OF BIOTECHNOLOGY

RAN Translation in Huntington Disease

(2015) Monica Bañez-Coronel et al.   NEURON

Systematic humanization of yeast genes reveals conserved functions and genetic modularity

(2015) A. H. Kachroo et al.   SCIENCE

New complexes containing the internal alternative NADH dehydrogenase (Ndi1) in mitochondria ofSaccharomyces cerevisiae

(2015) M. G. Matus-Ortega et al.   YEAST

Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster

(2015) Anika E. Wagner et al.   Oncotarget

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

High-Throughput Screen of Natural Product Extracts in A Yeast Model of Polyglutamine Proteotoxicity

(2014) Gladis M. Walter et al.   Chemical Biology & Drug Design

Yeast lipid metabolism at a glance

(2014) Lisa Klug et al.   FEMS YEAST RESEARCH

A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease

(2014) Siddharth Nath et al.   HUMAN MOLECULAR GENETICS

Iron dysregulation in Huntington's disease

(2014) Michelle Muller et al.   JOURNAL OF NEUROCHEMISTRY

Targets for future clinical trials in Huntington's disease: What's in the pipeline?

(2014) Edward J. Wild et al.   MOVEMENT DISORDERS

Huntington disease: natural history, biomarkers and prospects for therapeutics

(2014) Christopher A. Ross et al.   Nature Reviews Neurology

Potential function for the Huntingtin protein as a scaffold for selective autophagy

(2014) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome

(2014) Leslie Ripaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants

(2014) Reed B. Wickner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease

(2014) D.C. Butler et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The many ways to age for a single yeast cell

(2014) Didac Carmona-Gutierrez et al.   YEAST

The Reference Genome Sequence of Saccharomyces cerevisiae : Then and Now

(2014) Stacia R. Engel et al.   G3-Genes Genomes Genetics

Cytotoxicity of Mutant Huntingtin Fragment in Yeast Can Be Modulated by the Expression Level of Wild Type Huntingtin Fragment

(2013) Aliabbas Ahmedbhai Saleh et al.   ACS Chemical Neuroscience

The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age-associated inflammation and oxidative stress in healthy rats

(2013) Yucun Niu et al.   AGING CELL

PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

(2013) Sae-Hun Park et al.   CELL

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Pichia pastoris: protein production host and model organism for biomedical research

(2013) Brigitte Gasser et al.   Future Microbiology

Autophagic Processes in Yeast: Mechanism, Machinery and Regulation

(2013) F. Reggiori et al.   GENETICS

Harnessing the power of yeast to unravel the molecular basis of neurodegeneration

(2013) Sandra Tenreiro et al.   JOURNAL OF NEUROCHEMISTRY

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Intrabodies as Neuroprotective Therapeutics

(2013) Anne Messer et al.   Neurotherapeutics

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

(2013) S. L. Crick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma

(2013) Caroline Menard et al.   Frontiers in Cellular Neuroscience

Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110

(2013) Y Kuo et al.   Cell Death & Disease

A network of genes connects polyglutamine toxicity to ploidy control in yeast

(2013) Christoph J.O. Kaiser et al.   Nature Communications

Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model

(2013) Mimi Cushman-Nick et al.   PLoS Genetics

Yeast Programed Cell Death and Aging

(2013) Manuela Côrte-Real et al.   Frontiers in Oncology

Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?

(2013) Anja Mähler et al.   EPMA Journal

Targeting Kynurenine 3-Monooxygenase (KMO): Implications for Therapy in Huntingtons Disease

(2012) Mathuravani A. Thevandavakkam et al.   CNS & Neurological Disorders-Drug Targets

Contribution of Yeast Models to Neurodegeneration Research

(2012) Clara Pereira et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Intercellular (Mis)communication in Neurodegenerative Disease

(2012) Gwenn A. Garden et al.   NEURON

Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Mice via a Non-Cell Autonomous Mechanism

(2012) H. Akiko Popiel et al.   PLoS One

Modeling ALS and FTLD proteinopathies in yeast: An efficient approach for studying protein aggregation and toxicity

(2012) Dmitry Kryndushkin et al.   Prion

Modeling Huntington disease in yeast: Perspectives and future directions

(2012) Robert P. Mason et al.   Prion

Polyglutamine misfolding in yeast: Toxic and protective aggregation

(2012) Martin L. Duennwald   Prion

A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity

(2012) Mónica Bañez-Coronel et al.   PLoS Genetics

Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration

(2012) Ralf J. Braun   Frontiers in Oncology

Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation

(2011) M. Alba Sorolla et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Unexpected link between anaphase promoting complex and the toxicity of expanded polyglutamines expressed in yeast

(2011) Natalia A. Bocharova et al.   CELL CYCLE

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

(2011) Susanna Campesan et al.   CURRENT BIOLOGY

Modeling Neurodegeneration in Zebrafish

(2011) Yanwei Xi et al.   Current Neurology and Neuroscience Reports

A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis

(2011) Sabrina Büttner et al.   EMBO JOURNAL

Cell Signals, Cell Contacts, and the Organization of Yeast Communities

(2011) Saul M. Honigberg   EUKARYOTIC CELL

Protein aggregates in Huntington's disease

(2011) Montserrat Arrasate et al.   EXPERIMENTAL NEUROLOGY

Systems biology of yeast cell death

(2011) Ana Joyce Munoz et al.   FEMS YEAST RESEARCH

Yeast: An Experimental Organism for 21st Century Biology

(2011) David Botstein et al.   GENETICS

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

(2011) Derliz Mereles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference

(2011) Mateusz de Mezer et al.   NUCLEIC ACIDS RESEARCH

Huntington's disease: a clinical review

(2011) Raymund A.C. Roos   Orphanet Journal of Rare Diseases

Huntington's Disease

(2011) S. Finkbeiner   Cold Spring Harbor Perspectives in Biology

Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extendsDrosophilalifespan

(2010) Sepehr Bahadorani et al.   AGING CELL

Applying Hsp104 to protein-misfolding disordersThis paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.

(2010) Shilpa Vashist et al.   Biochemistry and Cell Biology

Apoptosis in yeast: triggers, pathways, subroutines

(2010) D Carmona-Gutierrez et al.   CELL DEATH AND DIFFERENTIATION

Simple is good: yeast models of neurodegeneration

(2010) Sandra Tenreiro et al.   FEMS YEAST RESEARCH

Yeast Models of Human Mitochondrial Diseases

(2010) Antoni Barrientos   IUBMB LIFE

Neuroinflammation in Huntington’s disease

(2010) Thomas Möller   JOURNAL OF NEURAL TRANSMISSION

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

(2010) Vikram Khurana et al.   NATURE REVIEWS NEUROSCIENCE

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction

(2010) A. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences

(2010) Vinal V. Lakhani et al.   PLoS Computational Biology

Hsp104 is essential for the selective degradation in yeast of polyglutamine expanded ataxin-1 but not most misfolded proteins generally

(2009) Do Hee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein aggregation and neurodegeneration: Clues from a yeast model of Huntington’s disease

(2009) N. Bocharova et al.   BIOCHEMISTRY-MOSCOW

Suppression of polyglutamine-induced cytotoxicity in Saccharomyces cerevisiae by enhancement of mitochondrial biogenesis

(2009) Alejandro Ocampo et al.   FASEB JOURNAL

(−)-Epigallocatechin-3-Gallate (EGCG) Maintains κ-Casein in Its Pre-Fibrillar State without Redirecting Its Aggregation Pathway

(2009) Sean A. Hudson et al.   JOURNAL OF MOLECULAR BIOLOGY

Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease

(2009) A. L. Southwell et al.   JOURNAL OF NEUROSCIENCE

Beyond the brain: widespread pathology in Huntington's disease

(2009) Jorien MM van der Burg et al.   LANCET NEUROLOGY

Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

(2009) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Neuroprotective Effect of Long-term NDI1 Gene Expression in a Chronic Mouse Model of Parkinson Disorder

(2009) Jennifer Barber-Singh et al.   REJUVENATION RESEARCH

Protein folding diseases and neurodegeneration: Lessons learned from yeast

(2008) Joris Winderickx et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

From the bakery to the brain business: developing inducible yeast models of human neurodegenerative disorders

(2008) Alejandro Ocampo et al.   BIOTECHNIQUES

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

The Stress Rheostat: An Interplay Between the Unfolded Protein Response (UPR) and Autophagy in Neurodegeneration

(2008) Soledad Matus et al.   CURRENT MOLECULAR MEDICINE

Huntington’s disease: degradation of mutant huntingtin by autophagy

(2008) Sovan Sarkar et al.   FEBS Journal

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

(2008) Christophe Lo Bianco et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity

(2008) A. L. Southwell et al.   JOURNAL OF NEUROSCIENCE

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

(2008) B. S. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease

(2003) A. J. Morton et al.   JOURNAL OF NEUROCHEMISTRY