Cartilage biology in osteoarthritis—lessons from developmental biology

The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation

(2011) Yang Gao et al.   DEVELOPMENTAL BIOLOGY

Replication studies in various ethnic populations do not support the association of the HIF-2α SNP rs17039192 with knee osteoarthritis

(2011) Masahiro Nakajima et al.   NATURE MEDICINE

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

(2011) Elisa Araldi et al.   NATURE MEDICINE

Proteolytic Cleavage of Versican During Limb Joint Development

(2010) Anthony A. Capehart   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

(2010) M. Daans et al.   ANNALS OF THE RHEUMATIC DISEASES

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

(2010) E. Evangelou et al.   ANNALS OF THE RHEUMATIC DISEASES

Premature arthritis is a distinct type II collagen phenotype

(2010) Peter Kannu et al.   ARTHRITIS AND RHEUMATISM

Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

(2010) Lin Xu et al.   ARTHRITIS AND RHEUMATISM

Adult presentation of Stickler syndrome type III

(2010) Kayi Li et al.   CLINICAL RHEUMATOLOGY

Relationship between joint shape and the development of osteoarthritis

(2010) Julie C Baker-LePain et al.   CURRENT OPINION IN RHEUMATOLOGY

Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage

(2010) Peter Dy et al.   DEVELOPMENTAL BIOLOGY

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

GADD45β EnhancesCol10a1Transcription via the MTK1/MKK3/6/p38 Axis and Activation of C/EBPβ-TAD4 in Terminally Differentiating Chondrocytes

(2010) Kaneyuki Tsuchimochi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways

(2010) Lea M Gunnell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulation of UDP-glucose dehydrogenase is sufficient to modulate hyaluronan production and release, control sulfated GAG synthesis, and promote chondrogenesis

(2010) Claire E. Clarkin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Homeobox genes d11–d13 and a13 control mouse autopod cortical bone and joint formation

(2010) Pablo Villavicencio-Lorini et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Genetic epidemiology of hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   Nature Reviews Rheumatology

010 IS FOLLISTATIN-LIKE 3 OR FSTL3 NECESSARY FOR JOINT HEALTH?

(2010) B. Poulet et al.   OSTEOARTHRITIS AND CARTILAGE

Association of a single nucleotide polymorphism in Tbx4 with developmental dysplasia of the hip: a case-control study

(2010) K. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Identification and Clonal Characterisation of a Progenitor Cell Sub-Population in Normal Human Articular Cartilage

(2010) Rebecca Williams et al.   PLoS One

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

(2010) S. Otsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand

(2009) Evangelos Evangelou et al.   ARTHRITIS AND RHEUMATISM

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Calcification of articular cartilage in human osteoarthritis

(2009) M. Fuerst et al.   ARTHRITIS AND RHEUMATISM

Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women

(2009) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb

(2009) K. Matsumoto et al.   DEVELOPMENT

The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf

(2009) I. Eshkar-Oren et al.   DEVELOPMENT

Chondrogenesis, joint formation, and articular cartilage regeneration

(2009) Ikemefuna Onyekwelu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Pattern Recognition Receptor CD36 Is a Chondrocyte Hypertrophy Marker Associated with Suppression of Catabolic Responses and Promotion of Repair Responses to Inflammatory Stimuli

(2009) D. L. Cecil et al.   JOURNAL OF IMMUNOLOGY

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Site specific osteoarthritis and the index to ring finger length ratio

(2009) B. Ferraro et al.   OSTEOARTHRITIS AND CARTILAGE

C/EBPβ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2

(2009) Makoto Hirata et al.   PLoS One

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development

(2009) T. J. Mead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

(2008) Francesco Dell'Accio et al.   ARTHRITIS AND RHEUMATISM

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis

(2008) Eiki Koyama et al.   DEVELOPMENTAL BIOLOGY

A critical evaluation of specific aspects of joint development

(2008) A.A. Pitsillides et al.   DEVELOPMENTAL DYNAMICS

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility

(2008) K. Chapman et al.   HUMAN MOLECULAR GENETICS

ALK1 Opposes ALK5/Smad3 Signaling and Expression of Extracellular Matrix Components in Human Chondrocytes

(2008) Kenneth W Finnson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Familial osteochondritis dissecans associated with early osteoarthritis and disproportionate short stature

(2008) E.-L. Stattin et al.   OSTEOARTHRITIS AND CARTILAGE