Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

(2011) Peter L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

COMP-Ang1 stimulates HIF-1 -mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment

(2011) S.-W. Youn et al.   BLOOD

The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair

(2011) Stefan Koch et al.   GASTROENTEROLOGY

Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1

(2011) Jin Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Secreted Frizzled-Related Protein 4

(2010) Ajit Muley et al.   AMERICAN JOURNAL OF PATHOLOGY

The Wnt Antagonist Dickkopf-1 Increases Endothelial Progenitor Cell Angiogenic Potential

(2010) David M. Smadja et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway

(2010) Gerhard Krönke et al.   ARTHRITIS AND RHEUMATISM

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees

(2010) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Opposing roles for HIF-1  and HIF-2  in the regulation of angiogenesis by mononuclear phagocytes

(2010) T. D. Eubank et al.   BLOOD

Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation

(2010) Jun Guo et al.   Cell Metabolism

Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation

(2010) Lei Wei et al.   DEVELOPMENTAL BIOLOGY

Platelet-derived Growth Factor-DD Targeting Arrests Pathological Angiogenesis by Modulating Glycogen Synthase Kinase-3β Phosphorylation

(2010) Anil Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of β-catenin signaling

(2010) Lai Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy

(2010) F. de Nigris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis

(2010) D. A. Walsh et al.   RHEUMATOLOGY

Expression levels and association of gelatinases MMP-2 and MMP-9 and collagenases MMP-1 and MMP-13 with VEGF in synovial fluid of patients with arthritis

(2010) Kyoung Soo Kim et al.   RHEUMATOLOGY INTERNATIONAL

Expression of β-catenin in rheumatoid arthritis fibroblast-like synoviocytes

(2010) CY Xiao et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

(2010) Isabel García-Arnandis et al.   ARTHRITIS RESEARCH & THERAPY

Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints

(2009) S. Uderhardt et al.   ANNALS OF THE RHEUMATIC DISEASES

Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1α/vascular endothelial growth factor-mediated pathway in immunodeficient mice

(2009) Manuel J. del Rey et al.   ARTHRITIS AND RHEUMATISM

Inhibition of HIF-1α activity by BP-1 ameliorates adjuvant induced arthritis in rats

(2009) J. Shankar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Dickkopf-1 expression accelerates bone cell apoptosis in femoral head osteonecrosis

(2009) Jih-Yang Ko et al.   BONE

Secreted Frizzle-Related Protein 2 Stimulates Angiogenesis via a Calcineurin/NFAT Signaling Pathway

(2009) A. Courtwright et al.   CANCER RESEARCH

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling

(2009) Andrew Sunters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Endothelial Cell Senescence by Lithium-induced Matrix Metalloproteinase-1 Expression

(2009) Ian T. Struewing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt/β-Catenin and Retinoic Acid Receptor Signaling Pathways Interact to Regulate Chondrocyte Function and Matrix Turnover

(2009) Rika Yasuhara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dickkopf-1 Promotes Hyperglycemia-Induced Accumulation of Mesangial Matrix and Renal Dysfunction

(2009) C.-L. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

N-Cadherin Negatively Regulates Osteoblast Proliferation and Survival by Antagonizing Wnt, ERK and PI3K/Akt Signalling

(2009) Eric Haÿ et al.   PLoS One

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

The role of Dickkopf-1 in bone development, homeostasis, and disease

(2008) J. J. Pinzone et al.   BLOOD

The Wnt Antagonist Dickkopf-1 Mobilizes Vasculogenic Progenitor Cells via Activation of the Bone Marrow Endosteal Stem Cell Niche

(2008) Alexandra Aicher et al.   CIRCULATION RESEARCH

Angiogenesis in osteoarthritis

(2008) Sadaf Ashraf et al.   CURRENT OPINION IN RHEUMATOLOGY

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis

(2008) Eiki Koyama et al.   DEVELOPMENTAL BIOLOGY

Modulation of Dickkopf-1 Attenuates Glucocorticoid Induction of Osteoblast Apoptosis, Adipocytic Differentiation, and Bone Mass Loss

(2008) Feng-Sheng Wang et al.   ENDOCRINOLOGY

Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density

(2008) K. Ellwanger et al.   MOLECULAR AND CELLULAR BIOLOGY

Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint

(2008) L.-H. Weng et al.   OSTEOARTHRITIS AND CARTILAGE