Are Platelets Cells? And if Yes, are They Immune Cells?

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

(2014) L. H. Boudreau et al.   BLOOD

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis

(2014) M. Koupenova et al.   BLOOD

Milestones in understanding platelet production: a historical overview

(2014) David J. Kuter   BRITISH JOURNAL OF HAEMATOLOGY

Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation

(2014) Kellie R. Machlus et al.   BRITISH JOURNAL OF HAEMATOLOGY

Human platelets express Toll-like receptor 3 and respond to poly I:C

(2014) Antonio-Santos Anabel et al.   HUMAN IMMUNOLOGY

Proteasome function is required for platelet production

(2014) Dallas S. Shi et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelet Activation and Apoptosis Modulate Monocyte Inflammatory Responses in Dengue

(2014) Eugenio D. Hottz et al.   JOURNAL OF IMMUNOLOGY

Role of Siglec-7 in Apoptosis in Human Platelets

(2014) Kim Anh Nguyen et al.   PLoS One

In Vivo Characterization of Neutrophil Extracellular Traps in Various Organs of a Murine Sepsis Model

(2014) Koji Tanaka et al.   PLoS One

NETosis: A New Factor in Tumor Progression and Cancer-Associated Thrombosis

(2014) Melanie Demers et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Serotonin Enhances Megakaryopoiesis and Proplatelet Formation via p-Erk1/2 and F-Actin Reorganization

(2014) Jie Yu Ye et al.   STEM CELLS

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis

(2014) Kakali Ghoshal et al.   TheScientificWorldJOURNAL

Platelet immunology in fungal infections

(2014) Cornelia Speth et al.   THROMBOSIS AND HAEMOSTASIS

Immune functions of platelets

(2014) Christoph Bode et al.   THROMBOSIS AND HAEMOSTASIS

Coordinate expression of transcripts and proteins in platelets

(2013) J. W. Rowley et al.   BLOOD

Selective triggering of platelet apoptosis, platelet activation or both

(2013) Armen V. Gyulkhandanyan et al.   BRITISH JOURNAL OF HAEMATOLOGY

Role of NF-κB Pathway on Platelet Activation

(2013) Mirta Schattner   CIRCULATION RESEARCH

Platelets as Cellular Effectors of Inflammation in Vascular Diseases

(2013) Matthew T. Rondina et al.   CIRCULATION RESEARCH

Platelet Abnormalities during Colonic Inflammation

(2013) Serena L. S. Yan et al.   INFLAMMATORY BOWEL DISEASES

Functional consequences of platelet binding to T lymphocytes in inflammation

(2013) Carlos Zamora et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Distinct effects of Re- and S-forms of LPS on modulating platelet activation

(2013) J. Kappelmayer et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

Platelet-macrophage partnership in innate immunity and inflammation

(2013) Alberto Mantovani et al.   NATURE IMMUNOLOGY

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Crosstalk between platelets and the complement system in immune protection and disease

(2013) Harald F. Langer et al.   THROMBOSIS AND HAEMOSTASIS

Regulation of platelet responses triggered by Toll-like receptor 2 and 4 ligands is another non-genomic role of nuclear factor-kappaB

(2013) Leonardo Rivadeneyra et al.   THROMBOSIS RESEARCH

Multifarious roles of sialic acids in immunity

(2012) Ajit Varki et al.   Annals of the New York Academy of Sciences

Platelets in Lung Biology

(2012) Andrew S. Weyrich et al.   Annual Review of Physiology

Losing a "nucleus" to gain a cytoplasm

(2012) J. Palis   BLOOD

Signaling and cytoskeletal requirements in erythroblast enucleation

(2012) D. G. Konstantinidis et al.   BLOOD

Platelets can enhance vascular permeability

(2012) N. Cloutier et al.   BLOOD

Engagement of Platelet Toll-Like Receptor 9 by Novel Endogenous Ligands Promotes Platelet Hyperreactivity and Thrombosis

(2012) Soumya Panigrahi et al.   CIRCULATION RESEARCH

Human platelets can discriminate between various bacterial LPS isoforms via TLR4 signaling and differential cytokine secretion

(2012) Julien Berthet et al.   CLINICAL IMMUNOLOGY

Platelet mRNA

(2012) Jesse W. Rowley et al.   CURRENT OPINION IN HEMATOLOGY

T granules in human platelets function in TLR9 organization and signaling

(2012) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelets Present Antigen in the Context of MHC Class I

(2012) L. M. Chapman et al.   JOURNAL OF IMMUNOLOGY

Platelet Apoptosis and Apoptotic Platelet Clearance by Macrophages in Secondary Dengue Virus Infections

(2012) Maria Terrese G. Alonzo et al.   JOURNAL OF INFECTIOUS DISEASES

Platelets: key players in vascular inflammation

(2012) Delia Projahn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Platelets: active players in the pathogenesis of arthritis and SLE

(2012) Eric Boilard et al.   Nature Reviews Rheumatology

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood platelet production and morphology

(2012) Alessandro Malara et al.   THROMBOSIS RESEARCH

Three-Stage Ex Vivo Expansion of High-Ploidy Megakaryocytic Cells: Toward Large-Scale Platelet Production

(2012) Swapna Panuganti et al.   TISSUE ENGINEERING PART A

Platelets and cytokines: How and why?

(2012) O. Garraud et al.   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes

(2011) J. W. Rowley et al.   BLOOD

Apoptosis in the anucleate platelet

(2011) Valery Leytin   BLOOD REVIEWS

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation

(2011) D. COX et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet-derived microparticles cause CD154-dependent activation of dendritic cells

(2011) Shosaku Nomura et al.   PLATELETS

Platelet and Neutrophil Responses to Gram Positive Pathogens in Patients with Bacteremic Infection

(2011) Daniel Johansson et al.   PLoS One

Platelets, inflammation and tissue regeneration

(2011) Alan Nurden   THROMBOSIS AND HAEMOSTASIS

Deciphering the human platelet sheddome

(2010) K. P. Fong et al.   BLOOD

Procoagulant platelets: are they necrotic?

(2010) S. P. Jackson et al.   BLOOD

Mechanisms of oral bacteria-induced platelet activation

(2010) Archibald McNicol et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Molecular Pathways Linking Inflammation and Cancer

(2010) A. Mantovani   CURRENT MOLECULAR MEDICINE

Clinical relevance of microparticles from platelets and megakaryocytes

(2010) Joseph E Italiano et al.   CURRENT OPINION IN HEMATOLOGY

Pathophysiology of transfusion-related acute lung injury

(2010) Mark R Looney et al.   CURRENT OPINION IN HEMATOLOGY

Bacterial–platelet interactions: virulence meets host defense

(2010) Michael R Yeaman   Future Microbiology

Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration

(2010) Kristin N. Kornerup et al.   JOURNAL OF APPLIED PHYSIOLOGY

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Nuclear Emancipation: A Platelet Tour de Force

(2010) S. L. Spinelli et al.   Science Signaling

Platelet- and Megakaryocyte-Derived Microparticles

(2010) Robert Flaumenhaft et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Platelets at the interface between thrombosis, inflammation and immunity

(2010) Richard P. Phipps   THROMBOSIS RESEARCH

Pathogen sensing, subsequent signalling, and signalosome in human platelets

(2010) Olivier Garraud et al.   THROMBOSIS RESEARCH

Platelet transfusions: Impact on hemostasis, thrombosis, inflammation and clinical outcomes

(2010) Majed A. Refaai et al.   THROMBOSIS RESEARCH

De novo protein synthesis in mature platelets: a consideration for transfusion medicine

(2010) P. Schubert et al.   VOX SANGUINIS

Hyaluronan, Platelets, and Monocytes

(2009) Gustavo B. Menezes et al.   AMERICAN JOURNAL OF PATHOLOGY

Platelet influence on T- and B-cell responses

(2009) Jennifer M. Sowa et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Platelets and Megakaryocytes Contain Functional Nuclear Factor-κB

(2009) Sherry L. Spinelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells

(2009) G. Anani Sarab et al.   BLOOD

Platelet–bacterial interactions

(2009) Steven W. Kerrigan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Platelets and viruses: an ambivalent relationship

(2009) Claire Flaujac et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Platelets in defense against bacterial pathogens

(2009) Michael R. Yeaman   CELLULAR AND MOLECULAR LIFE SCIENCES

Dangerous connections: neutrophils and the phagocytic clearance of activated platelets

(2009) Angelo A Manfredi et al.   CURRENT OPINION IN HEMATOLOGY

The platelet as an immune cell—CD40 ligand and transfusion immunomodulation

(2009) Neil Blumberg et al.   IMMUNOLOGIC RESEARCH

Bacteria–platelet interactions

(2009) D. COX   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet functions beyond hemostasis

(2009) S. S. SMYTH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Protein synthesis by platelets: historical and new perspectives

(2009) A. S. WEYRICH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

NF-κB inhibitors impair platelet activation responses

(2009) E. MALAVER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes

(2009) Lea M. Beaulieu et al.   THROMBOSIS RESEARCH

Platelet power: sticky problems for sticky parasites?

(2009) Richard J. Pleass   TRENDS IN PARASITOLOGY

Amicus or Adversary

(2008) Fernando A. Bozza et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Signal-Dependent Protein Synthesis by Activated Platelets

(2008) Guy A. Zimmerman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles

(2008) D. L. Sprague et al.   BLOOD

Direct contact of platelets and their released products exert different effects on human dendritic cell maturation

(2008) Hind Hamzeh-Cognasse et al.   BMC IMMUNOLOGY

Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase

(2008) Price Blair et al.   CIRCULATION RESEARCH

Platelet-lymphocyte cross-talk

(2008) Nailin Li   JOURNAL OF LEUKOCYTE BIOLOGY

Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis

(2008) A. C. MA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Donor platelets stored for at least 3 days can elicit activation marker expression by the recipient's blood mononuclear cells: an in vitrostudy

(2008) Fabrice Cognasse et al.   TRANSFUSION

Platelet Chemokines and Chemokine Receptors: Linking Hemostasis, Inflammation, and Host Defense

(2003) ADRIAN R.L. GEAR et al.   MICROCIRCULATION