Article
Biochemistry & Molecular Biology
Natalia Rukoyatkina, Valentina Shpakova, Julia Sudnitsyna, Michael Panteleev, Stephanie Makhoul, Stepan Gambaryan, Kerstin Jurk
Summary: Our study demonstrated that curcumin exerts inhibitory effects on platelets through promoting procoagulant platelet formation instead of platelet apoptosis. Additionally, curcumin induced autophagy in platelets and inhibited platelet P-glycoprotein activity, contributing to its inhibitory effect on platelets through complex processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Lacey Johnson, Pearl Lei, Lauren Waters, Matthew P. Padula, Denese C. Marks
Summary: The aim of this study was to define the phenotype of in vitro generated platelet subpopulations and identify the subpopulations present in cryopreserved components. The study found that cryopreserved platelets contained procoagulant platelets and a novel population that did not align with the phenotype of aggregatory or apoptotic subpopulations.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Valentina Shpakova, Natalia Rukoyatkina, Nada Al Arawe, Anna Prilepskaya, Alexandra Kharazova, Iraida Sharina, Stepan Gambaryan, Emil Martin
Summary: This study reveals the molecular mechanisms of the 12-LOX inhibitor ML355 on platelets, demonstrating its antiplatelet and protective effects, which may be significant for antiplatelet and anticancer therapy.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Immunology
Despina Michailidou, Peter C. Grayson, Payton Hermanson, Jorge Armando Gonzalez Chapa, David Cuthbertson, Nader A. Khalidi, Curry L. Koening, Carol A. Langford, Carol A. Mcalear, Larry W. Moreland, Christian Pagnoux, Philip Seo, Antoine G. Sreih, Kenneth J. Warrington, Paul A. Monach, Peter A. Merkel, Christian Lood
Summary: Markers of extracellular mitochondria are present in giant cell arteritis (GCA) patients, which may contribute to excessive inflammation and platelet activation. Plasma from GCA patients promotes increased production of mitochondrial-mediated cytokines and higher platelet activation compared to healthy individuals.
CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Reza Haschemi, Lukas Maria Gockel, Gerd Bendas, Martin Schlesinger
Summary: Pancreatic cancer patients are at a higher risk of venous thrombosis, with platelets playing a key role in clot formation. The combination of tissue factor-induced thrombin formation by cancer cells and their binding to platelet P-selectin is responsible for platelet activation in AsPC-1 and Capan-2 pancreatic cancer cells. Simultaneously blocking both pathways with heparin may be an effective approach to reducing hypercoagulability in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Agathi Ntzouvani, Smaragdi Antonopoulou, Elizabeth Fragopoulou, Meropi D. Kontogianni, Tzortzis Nomikos, Anastasia Mikellidi, Marianna Xanthopoulou, Nick Kalogeropoulos, Demosthenes Panagiotakos
Summary: This study found that consumption of enriched farmed gilthead sea bream did not have a greater effect on coagulation markers in adults compared to conventionally fed fish.
Article
Medicine, General & Internal
Eleni Vrigkou, Argirios Tsantes, Dimitrios Konstantonis, Evdoxia Rapti, Eirini Maratou, Athanasios Pappas, Panagiotis Halvatsiotis, Iraklis Tsangaris
Summary: This study evaluated platelet and coagulation function in patients with chronic thromboembolic pulmonary hypertension (CTEPH), and found abnormalities in platelet aggregation, fibrinolysis, thrombin generation, and other clot formation markers in these patients.
Article
Endocrinology & Metabolism
Christina Kohlmorgen, Stephen Gerfer, Kathrin Feldmann, Soeren Twarock, Sonja Hartwig, Stefan Lehr, Meike Klier, Irena Krueger, Carolin Helten, Petra Keul, Sabine Kahl, Amin Polzin, Margitta Elvers, Ulrich Floegel, Malte Kelm, Bodo Levkau, Michael Roden, Jens W. Fischer, Maria Grandoch
Summary: The study investigated the effect of SGLT2i dapagliflozin on platelet activation and inflammation in atherogenesis. Results showed that dapagliflozin treatment reduced atherosclerotic lesion development, circulating platelet-leucocyte aggregates, and aortic macrophage infiltration. Additionally, dapagliflozin decreased platelet activation and thrombin generation without affecting bleeding time.
Article
Pharmacology & Pharmacy
Xiaoye Li, Xiaochun Zhang, Qinchun Jin, Yanli Li, Daxin Zhou, Qianzhou Lv, Junbo Ge
Summary: This study compared post-procedure anticoagulation with dabigatran and rivaroxaban in patients who underwent LAAC. The results suggested that post-LAAC anticoagulation with dabigatran may increase the risk of DRT by enhancing platelet reactivity, as reflected in higher platelet activation biomarkers compared to rivaroxaban. Multivariate regression analysis indicated dabigatran use as an independent predictor of DRT.
FRONTIERS IN PHARMACOLOGY
(2021)