Immune functions of platelets

Interleukin 1 Receptor 1 and Interleukin 1β Regulate Megakaryocyte Maturation, Platelet Activation, and Transcript Profile During Inflammation in Mice and Humans

(2014) Lea M. Beaulieu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

(2014) Christine Koulis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis

(2014) M. Koupenova et al.   BLOOD

Coinhibitory Suppression of T Cell Activation by CD40 Protects Against Obesity and Adipose Tissue Inflammation in Mice

(2014) Dennis Wolf et al.   CIRCULATION

Towards Effective and Safe Thrombolysis and Thromboprophylaxis

(2014) Xiaowei Wang et al.   CIRCULATION RESEARCH

Acute Fluoxetine Treatment Induces Slow Rolling of Leukocytes on Endothelium in Mice

(2014) Nadine Herr et al.   PLoS One

Production of Serotonin by Tryptophan Hydroxylase 1 and Release via Platelets Contribute to Allergic Airway Inflammation

(2013) Thorsten Dürk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State

(2013) Julian I. Borissoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role for Platelet Glycoprotein Ib-IX and Effects of its Inhibition in Endotoxemia-Induced Thrombosis, Thrombocytopenia, and Mortality

(2013) Hong Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Relationship Among Circulating Inflammatory Proteins, Platelet Gene Expression, and Cardiovascular Risk

(2013) David D. McManus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

The Toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLCγ2 signalling cascade

(2013) Knut Fälker et al.   CELLULAR SIGNALLING

Integrin α 6 β 1 Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis

(2013) Mathieu Schaff et al.   CIRCULATION

Platelets as Cellular Effectors of Inflammation in Vascular Diseases

(2013) Matthew T. Rondina et al.   CIRCULATION RESEARCH

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

(2013) M Reilly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Platelets: bridging hemostasis, inflammation, and immunity

(2013) C. N. Jenne et al.   International Journal of Laboratory Hematology

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Platelet-derived PF4 reduces neutrophil apoptosis following arterial occlusion

(2013) Dirk Lievens et al.   THROMBOSIS AND HAEMOSTASIS

Regulation of platelet responses triggered by Toll-like receptor 2 and 4 ligands is another non-genomic role of nuclear factor-kappaB

(2013) Leonardo Rivadeneyra et al.   THROMBOSIS RESEARCH

Platelet Activation, P-Selectin, and Eosinophil β1-Integrin Activation in Asthma

(2012) Mats W. Johansson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Examination of the Relationship Between Antimicrobials and Thrombocytosis

(2012) Christy C Forehand et al.   ANNALS OF PHARMACOTHERAPY

Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosis

(2012) Norma Maugeri et al.   AUTOIMMUNITY

Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies

(2012) T. A. Fuchs et al.   BLOOD

Platelets can enhance vascular permeability

(2012) N. Cloutier et al.   BLOOD

Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice

(2012) D. Duerschmied et al.   BLOOD

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Novel Single-Chain Antibody-Targeted Microbubbles for Molecular Ultrasound Imaging of Thrombosis

(2012) Xiaowei Wang et al.   CIRCULATION

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2012) Harald F. Langer et al.   CIRCULATION RESEARCH

Engagement of Platelet Toll-Like Receptor 9 by Novel Endogenous Ligands Promotes Platelet Hyperreactivity and Thrombosis

(2012) Soumya Panigrahi et al.   CIRCULATION RESEARCH

Human platelets can discriminate between various bacterial LPS isoforms via TLR4 signaling and differential cytokine secretion

(2012) Julien Berthet et al.   CLINICAL IMMUNOLOGY

Human platelets efficiently kill IgG-opsonizedE. coli

(2012) Anum H. Riaz et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

T granules in human platelets function in TLR9 organization and signaling

(2012) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis

(2012) M. Derive et al.   JOURNAL OF IMMUNOLOGY

Aspirin for Preventing the Recurrence of Venous Thromboembolism

(2012) Cecilia Becattini et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet-Associated CD40/CD154 Mediates Remote Tissue Damage after Mesenteric Ischemia/Reperfusion Injury

(2012) Peter H. Lapchak et al.   PLoS One

Presence of luminal neutrophil extracellular traps in atherosclerosis

(2012) Remco T. A. Megens et al.   THROMBOSIS AND HAEMOSTASIS

The role of thrombin receptors PAR1 and PAR4 for PAI-1 storage, synthesis and secretion by human platelets

(2012) Martina Nylander et al.   THROMBOSIS RESEARCH

Platelet-Derived Growth Factor–Producing CD4+Foxp3+Regulatory T Lymphocytes Promote Lung Fibrosis

(2011) Sandra Lo Re et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Endothelial cell-borne platelet bridges selectively recruit monocytes in human and mouse models of vascular inflammation

(2011) Christopher J. Kuckleburg et al.   CARDIOVASCULAR RESEARCH

Phosphorylation of Vasodilator-Stimulated Phosphoprotein Prevents Platelet-Neutrophil Complex Formation and Dampens Myocardial Ischemia-Reperfusion Injury

(2011) David Köhler et al.   CIRCULATION

Binding of CD40L to Mac-1's I-Domain Involves the EQLKKSKTL Motif and Mediates Leukocyte Recruitment and Atherosclerosis—But Does Not Affect Immunity and Thrombosis in Mice

(2011) Dennis Wolf et al.   CIRCULATION RESEARCH

Thrombocytes are effectors of the innate immune system releasing human beta defensin-3

(2011) Mersedeh Tohidnezhad et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Molecular Magnetic Resonance Imaging Allows the Detection of Activated Platelets in a New Mouse Model of Coronary Artery Thrombosis

(2011) Daniel Duerschmied et al.   INVESTIGATIVE RADIOLOGY

Essential in vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation

(2011) Katsue Suzuki-Inoue   JOURNAL OF BIOCHEMISTRY

Native Thrombocidin-1 and Unfolded Thrombocidin-1 Exert Antimicrobial Activity via Distinct Structural Elements

(2011) Paulus H. S. Kwakman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet activation attracts a subpopulation of effector monocytes to sites ofLeishmania majorinfection

(2011) Ricardo Goncalves et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The septic milieu triggers expression of spliced tissue factor mRNA in human platelets

(2011) M. T. RONDINA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Efficient phagocytosis of periodontopathogens by neutrophils requires plasma factors, platelets and TLR2

(2011) A. ASSINGER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Chlamydia pneumoniae Induces Chemokine Expression by Platelets in Patients with Atherosclerosis

(2011) Abdelhad Al-Bannawi et al.   MEDICAL PRINCIPLES AND PRACTICE

A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3

(2011) Admar Verschoor et al.   NATURE IMMUNOLOGY

Platelets display potent antimicrobial activity and release human beta-defensin 2

(2011) Mersedeh Tohidnezhad et al.   PLATELETS

Requirements for Membrane Attack Complex Formation and Anaphylatoxins Binding to Collagen-Activated Platelets

(2011) Catherine Martel et al.   PLoS One

Monocyte-Platelet Interaction Induces a Pro-Inflammatory Phenotype in Circulating Monocytes

(2011) Gabriella Passacquale et al.   PLoS One

Co-stimulatory molecules in and beyond co-stimulation – tipping the balance in atherosclerosis?

(2011) Norbert Gerdes et al.   THROMBOSIS AND HAEMOSTASIS

Platelets in atherosclerosis

(2011) Philipp von Hundelshausen et al.   THROMBOSIS AND HAEMOSTASIS

Platelets, inflammation and tissue regeneration

(2011) Alan Nurden   THROMBOSIS AND HAEMOSTASIS

Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

(2011) Bjoern F. Kraemer et al.   PLoS Pathogens

Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1

(2010) Fong W. Lam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

(2010) D. Lievens et al.   BLOOD

IgG-complex stimulated platelets: A source of sCD40L and RANTES in initiation of inflammatory cascade

(2010) Adam J. Antczak et al.   CELLULAR IMMUNOLOGY

The Frequency and Clinical Significance of Thrombocytopenia Complicating Critical Illness

(2010) Phil Hui et al.   CHEST

Relation of Platelet and Leukocyte Inflammatory Transcripts to Body Mass Index in the Framingham Heart Study

(2010) Jane E. Freedman et al.   CIRCULATION

CXCL5 Regulates Chemokine Scavenging and Pulmonary Host Defense to Bacterial Infection

(2010) Junjie Mei et al.   IMMUNITY

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

(2010) Esther Lutgens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serotonin and its 5-HT2 receptor agonist DOI hydrochloride inhibit the oxidative burst in total leukocytes but not in isolated neutrophils

(2010) Lucie Prachařová et al.   LIFE SCIENCES

Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion

(2010) Sugiru Pak et al.   PLATELETS

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD40L-CD40 fuel ignites obesity

(2010) Marjorie Poggi et al.   THROMBOSIS AND HAEMOSTASIS

Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model

(2010) Xiaorong Zhou et al.   THROMBOSIS AND HAEMOSTASIS

Pathogen sensing, subsequent signalling, and signalosome in human platelets

(2010) Olivier Garraud et al.   THROMBOSIS RESEARCH

Platelet CD40L at the interface of adaptive immunity

(2010) Bennett D. Elzey et al.   THROMBOSIS RESEARCH

Methods for the Measurement of Platelet Function

(2009) Alan D. Michelson   AMERICAN JOURNAL OF CARDIOLOGY

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP

(2009) H. Falet et al.   BLOOD

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

(2009) L. Stefanini et al.   BLOOD

Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion

(2009) A. Brill et al.   CARDIOVASCULAR RESEARCH

Platelet Dense-Granule Secretion Plays a Critical Role in Thrombosis and Subsequent Vascular Remodeling in Atherosclerotic Mice

(2009) Sarah M. King et al.   CIRCULATION

Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway

(2009) G. Zhang et al.   JOURNAL OF IMMUNOLOGY

Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17)

(2009) D. DUERSCHMIED et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Integrins in platelet activation

(2009) B. NIESWANDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

5-Hydroxytryptamine Modulates Migration, Cytokine and Chemokine Release and T-Cell Priming Capacity of Dendritic Cells In Vitro and In Vivo

(2009) Tobias Müller et al.   PLoS One

Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection

(2009) B. J. McMorran et al.   SCIENCE

The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes

(2009) Lea M. Beaulieu et al.   THROMBOSIS RESEARCH

Cell Adhesion Mechanisms in Platelets

(2008) David Varga-Szabo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet Chemokines in Vascular Disease

(2008) Christian A. Gleissner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo

(2008) Christian Schulz et al.   BASIC RESEARCH IN CARDIOLOGY

The vessel wall and its interactions

(2008) D. D. Wagner et al.   BLOOD

Magnetic Resonance Imaging Contrast Agent Targeted Toward Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis

(2008) C. von zur Muhlen et al.   CIRCULATION

Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase

(2008) Price Blair et al.   CIRCULATION RESEARCH

Functional expression of IgA receptor FcαRI on human platelets

(2008) Kun Qian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases

(2008) J. M. van Gils et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Serotonin 5-Hydroxytryptamine2A Receptor Activation Suppresses Tumor Necrosis Factor- -Induced Inflammation with Extraordinary Potency

(2008) B. Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'

(2008) Christian J Kastrup et al.   Nature Chemical Biology

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

Allergen Induces the Migration of Platelets to Lung Tissue in Allergic Asthma

(2007) Simon C. Pitchford et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx

(2007) Daniel Chappell et al.   BIOLOGICAL CHEMISTRY