Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation

Crucial Role for Endoplasmic Reticulum Stress During Megakaryocyte Maturation

(2013) Jose J. Lopez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Abnormal megakaryocyte development and platelet function in Nbeal2-/- mice

(2013) W. H. A. Kahr et al.   BLOOD

Proplatelet generation in the mouse requires PKC -dependent RhoA inhibition

(2013) G. Gobbi et al.   BLOOD

Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response

(2013) E. M. Battinelli et al.   BLOOD

Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling

(2013) Y. Chen et al.   BLOOD

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

(2013) I. Pleines et al.   BLOOD

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

(2013) A. Mazharian et al.   BLOOD

Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning

(2013) T. S. Olson et al.   BLOOD

The incredible journey: From megakaryocyte development to platelet formation

(2013) Kellie R. Machlus et al.   JOURNAL OF CELL BIOLOGY

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

(2013) Carsten Deppermann et al.   JOURNAL OF CLINICAL INVESTIGATION

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation

(2013) Aae Suzuki et al.   PLoS One

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production

(2012) J. N. Thon et al.   BLOOD

T granules in human platelets function in TLR9 organization and signaling

(2012) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Microtubule and cortical forces determine platelet size during vascular platelet production

(2012) Jonathan N Thon et al.   Nature Communications

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation

(2011) S. Patel-Hett et al.   BLOOD

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis

(2011) E. M. Battinelli et al.   BLOOD

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

(2011) Emma C. Josefsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome

(2011) Walter HA Kahr et al.   NATURE GENETICS

Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome

(2011) Cornelis A Albers et al.   NATURE GENETICS

NBEAL2 is mutated in gray platelet syndrome and is required for biogenesis of platelet α-granules

(2011) Meral Gunay-Aygun et al.   NATURE GENETICS

Cytoskeletal mechanics of proplatelet maturation and platelet release

(2010) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Infusion of mature megakaryocytes into mice yields functional platelets

(2010) Rudy Fuentes et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression

(2009) H. Yang et al.   BLOOD

Platelet α-granules: Basic biology and clinical correlates

(2009) Price Blair et al.   BLOOD REVIEWS

Chediak-Higashi syndrome

(2009) Jerry Kaplan et al.   CURRENT OPINION IN HEMATOLOGY

Determinants of platelet number and regulation of thrombopoiesis

(2009) K. Kaushansky   Hematology-American Society of Hematology Education Program

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules

(2008) S. Patel-Hett et al.   BLOOD

A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia

(2008) Ian M Morison et al.   NATURE GENETICS