Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer

Endoplasmic reticulum stress associated responses in cancer

(2014) Wen-An Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

(2014) Ummuhan Demir et al.   BMC CANCER

Survival in Patients with High-Risk Prostate Cancer Is Predicted by miR-221, Which Regulates Proliferation, Apoptosis, and Invasion of Prostate Cancer Cells by Inhibiting IRF2 and SOCS3

(2014) B. Kneitz et al.   CANCER RESEARCH

Molecular Pathways: Preclinical Models and Clinical Trials with Metformin in Breast Cancer

(2014) A. M. Thompson   CLINICAL CANCER RESEARCH

Metformin significantly reduces incident prostate cancer risk in Taiwanese men with type 2 diabetes mellitus

(2014) Chin-Hsiao Tseng   EUROPEAN JOURNAL OF CANCER

Metformin Use and Prostate Cancer Risk

(2014) Mark A. Preston et al.   EUROPEAN UROLOGY

Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival

(2014) Chih-Hang Anthony Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis

(2014) Thomas Condamine et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic Simvastatin and Metformin Combination Chemotherapy for Osseous Metastatic Castration-Resistant Prostate Cancer

(2014) M. A. Babcook et al.   MOLECULAR CANCER THERAPEUTICS

A Novel ER Stress-Independent Function of the UPR in Angiogenesis

(2014) Hery Urra et al.   MOLECULAR CELL

MicroRNA regulons in tumor microenvironment

(2014) H I Suzuki et al.   ONCOGENE

Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells

(2014) Eveline A. I. F. Queiroz et al.   PLoS One

Small RNA combination therapy for lung cancer

(2014) W. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration

(2013) Seongho Ryu et al.   CANCER CELL

Metformin targets c-MYC oncogene to prevent prostate cancer

(2013) Tunde Akinyeke et al.   CARCINOGENESIS

Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma

(2013) L. Zheng et al.   CLINICAL CANCER RESEARCH

Neuronatin-mediated Aberrant Calcium Signaling and Endoplasmic Reticulum Stress Underlie Neuropathology in Lafora Disease

(2013) Jaiprakash Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential applications for biguanides in oncology

(2013) Michael Pollak   JOURNAL OF CLINICAL INVESTIGATION

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

(2013) H. A. Hirsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KSHV MicroRNAs Mediate Cellular Transformation and Tumorigenesis by Redundantly Targeting Cell Growth and Survival Pathways

(2013) Rosalie Moody et al.   PLoS Pathogens

miRNA-708 Control of CD44+ Prostate Cancer-Initiating Cells

(2012) S. Saini et al.   CANCER RESEARCH

Metformin Inhibits Growth of Thyroid Carcinoma Cells, Suppresses Self-Renewal of Derived Cancer Stem Cells, and Potentiates the Effect of Chemotherapeutic Agents

(2012) Guofang Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Neuronatin in a Subset of Glioblastoma Multiforme Tumor Progenitor Cells Is Associated with Increased Cell Proliferation and Shorter Patient Survival

(2012) David S. Xu et al.   PLoS One

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

MicroRNA-708 Induces Apoptosis and Suppresses Tumorigenicity in Renal Cancer Cells

(2011) S. Saini et al.   CANCER RESEARCH

Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Cα-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activat

(2010) Yong P Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting ER stress induced apoptosis and inflammation in cancer

(2010) Tom Verfaillie et al.   CANCER LETTERS

Neuronatin Promotes Neural Lineage in ESCs via Ca2+ Signaling

(2010) Hsuan-Hwai Lin et al.   STEM CELLS

Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic β-cells

(2008) Myung Kuk Joe et al.   CELLULAR SIGNALLING