MicroRNA regulons in tumor microenvironment

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-155 and MicroRNA-21 Promote the Expansion of Functional Myeloid-Derived Suppressor Cells

(2014) L. Li et al.   JOURNAL OF IMMUNOLOGY

Extracellular vesicles: emerging targets for cancer therapy

(2014) Pieter Vader et al.   TRENDS IN MOLECULAR MEDICINE

Hypoxia-regulated microRNAs in human cancer

(2013) Guomin Shen et al.   ACTA PHARMACOLOGICA SINICA

Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis

(2013) Brian Ell et al.   CANCER CELL

Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1

(2013) A. Bronisz et al.   CANCER RESEARCH

miR145 Targets the SOX9/ADAM17 Axis to Inhibit Tumor-Initiating Cells and IL-6-Mediated Paracrine Effects in Head and Neck Cancer

(2013) C.-C. Yu et al.   CANCER RESEARCH

miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

(2013) Jun Wei et al.   CANCER RESEARCH

Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation

(2013) Takatsugu Ishimoto et al.   CARCINOGENESIS

Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2

(2013) Tracy X. Cui et al.   IMMUNITY

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs Transfer from Human Macrophages to Hepato-Carcinoma Cells and Inhibit Proliferation

(2013) A. Aucher et al.   JOURNAL OF IMMUNOLOGY

Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes

(2013) H I Suzuki et al.   LEUKEMIA

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression

(2013) Jonathan Chou et al.   NATURE CELL BIOLOGY

Control of metastatic progression by microRNA regulatory networks

(2013) Nora Pencheva et al.   NATURE CELL BIOLOGY

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis

(2013) Yun Zhang et al.   NATURE CELL BIOLOGY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells

(2013) P Ceppi et al.   ONCOGENE

Expression, Tissue Distribution and Function of miR-21 in Esophageal Squamous Cell Carcinoma

(2013) Nazila Nouraee et al.   PLoS One

Identification of miR-30e* Regulation of Bmi1 Expression Mediated by Tumor-Associated Macrophages in Gastrointestinal Cancer

(2013) Hidetaka Sugihara et al.   PLoS One

Microenvironmental regulation of cancer metastasis by miRNAs

(2013) Yun Zhang et al.   TRENDS IN CELL BIOLOGY

MicroRNA-mediated control of macrophages and its implications for cancer

(2013) Mario Leonardo Squadrito et al.   TRENDS IN IMMUNOLOGY

Context-specific microRNA function in developmental complexity

(2013) A. P. Carroll et al.   Journal of Molecular Cell Biology

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

(2013) Ching-Wen Lin et al.   Nature Communications

Circulating miRNAs: cell–cell communication function?

(2013) A. Turchinovich et al.   Frontiers in Genetics

TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma

(2012) Pengyuan Yang et al.   CANCER CELL

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

Reprogramming Tumor-Associated Dendritic Cells In Vivo Using miRNA Mimetics Triggers Protective Immunity against Ovarian Cancer

(2012) J. R. Cubillos-Ruiz et al.   CANCER RESEARCH

Convergent Multi-miRNA Targeting of ApoE Drives LRP1/LRP8-Dependent Melanoma Metastasis and Angiogenesis

(2012) Nora Pencheva et al.   CELL

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

(2012) Marilena V. Iorio et al.   EMBO Molecular Medicine

MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Widespread inference of weighted microRNA-mediated gene regulation in cancer transcriptome analysis

(2012) Hiroshi I. Suzuki et al.   NUCLEIC ACIDS RESEARCH

Context-specific microRNA analysis: identification of functional microRNAs and their mRNA targets

(2012) Noa Bossel Ben-Moshe et al.   NUCLEIC ACIDS RESEARCH

microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin

(2012) F Muramatsu et al.   ONCOGENE

Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility

(2012) O Aprelikova et al.   ONCOGENE

Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

(2012) Xing Cai et al.   Journal of Molecular Cell Biology

MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer

(2012) A. K. Mitra et al.   Cancer Discovery

miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages

(2012) Mario Leonardo Squadrito et al.   Cell Reports

miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma

(2011) H. Matsuyama et al.   BLOOD

miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis

(2011) Avital Gaziel-Sovran et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L

(2011) Faegheh Jafarifar et al.   EMBO JOURNAL

Integrating contextual miRNA and protein signatures for diagnostic and treatment decisions in cancer

(2011) Lorenzo F Sempere   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Both miR-17-5p and miR-20a Alleviate Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating STAT3 Expression

(2011) M. Zhang et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1  Activity during Prolonged Hypoxia

(2011) U. Bruning et al.   MOLECULAR AND CELLULAR BIOLOGY

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

MCPIP1 Ribonuclease Antagonizes Dicer and Terminates MicroRNA Biogenesis through Precursor MicroRNA Degradation

(2011) Hiroshi I. Suzuki et al.   MOLECULAR CELL

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

(2011) A. Bronisz et al.   NATURE CELL BIOLOGY

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer

(2011) M Musumeci et al.   ONCOGENE

Identifying functional miRNA–mRNA regulatory modules with correspondence latent dirichlet allocation

(2010) Bing Liu et al.   BIOINFORMATICS

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

miR-126 functions as a tumour suppressor in human gastric cancer

(2010) Runhua Feng et al.   CANCER LETTERS

The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts

(2010) Olga Aprelikova et al.   CELL CYCLE

Fluorescence-Based Codetection with Protein Markers Reveals Distinct Cellular Compartments for Altered MicroRNA Expression in Solid Tumors

(2010) L. F. Sempere et al.   CLINICAL CANCER RESEARCH

Myeloid-derived suppressor cell heterogeneity and subset definition

(2010) Elisa Peranzoni et al.   CURRENT OPINION IN IMMUNOLOGY

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

(2010) Ilaria Marigo et al.   IMMUNITY

Emerging complexity of microRNA generation cascades

(2010) H. I. Suzuki et al.   JOURNAL OF BIOCHEMISTRY

miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells

(2010) Yuk Cheung Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of microRNA biogenesis: crosstalk between p53 network and microRNA processing pathway

(2010) Hiroshi I. Suzuki et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)

(2010) Evan M. Kroh et al.   METHODS

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

(2010) Li Ma et al.   NATURE CELL BIOLOGY

Towards computational prediction of microRNA function and activity

(2010) Igor Ulitsky et al.   NUCLEIC ACIDS RESEARCH

Hypoxia and RAS-signaling pathways converge on and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs

(2010) F Loayza-Puch et al.   ONCOGENE

Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression

(2010) S Dangi-Garimella et al.   ONCOGENE

microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling

(2010) Z. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-210 – micromanager of the hypoxia pathway

(2010) Xin Huang et al.   TRENDS IN MOLECULAR MEDICINE

GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis

(2009) Jan Piet van Hamburg et al.   ARTHRITIS AND RHEUMATISM

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

(2009) Aaron L Sarver et al.   BMC CANCER

MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

(2009) M. E. Crosby et al.   CANCER RESEARCH

p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy

(2009) Takahiro Hasebe et al.   HUMAN PATHOLOGY

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

Immune surveillance: a balance between protumor and antitumor immunity

(2008) Suzanne Ostrand-Rosenberg   CURRENT OPINION IN GENETICS & DEVELOPMENT

The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers

(2008) Chunguang Guo et al.   GENES CHROMOSOMES & CANCER

Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells

(2008) Ilaria Marigo et al.   IMMUNOLOGICAL REVIEWS

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE

No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas

(2008) Wen Qiu et al.   NATURE GENETICS

The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

(2008) Désirée Bonci et al.   NATURE MEDICINE

MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins

(2008) S. Sengupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA