Article
Health Care Sciences & Services
Hein Vincent Stroomberg, S. Benzon Larsen, G. Samso Lanthen, T. Kjaer Nielsen, J. T. Helgstrand, K. Brasso, A. Roder
Summary: This article introduces the Danish Prostate Cancer Registry (DaPCaR) and the Danish Prostate Registry (DanProst), the latter being a comprehensive centralized registry that includes all men who have undergone histological evaluation of the prostate tissue. DanProst is built on the assessment data from the Danish National Registry for Pathology and integrates data from multiple national registries.
JOURNAL OF MEDICAL SYSTEMS
(2023)
Article
Gastroenterology & Hepatology
Hyun-Soo Zhang, Yeunsoo Yang, Sunmi Lee, Sohee Park, Chung Mo Nam, Sun Ha Jee
Summary: This study employs three statistical methods to avoid immortal time bias and compares their results with a naive time-fixed analysis, concluding that metformin use is not associated with colorectal cancer incidence.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Health Care Sciences & Services
Seung In Seo, Tae Jun Kim, Chan Hyuk Park, Chang Seok Bang, Kyung Joo Lee, Jinseob Kim, Hyon Hee Kim, Woon Geon Shin
Summary: This study found that the use of metformin in patients with diabetes may reduce the risk of colorectal cancer incidence and improve overall survival, based on an analysis of the Korean National Health Insurance Service database.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Behavioral Sciences
Melinda Magyari, Hanna Joensen, Bjarne Laursen, Nils Koch-Henriksen
Summary: The Danish Multiple Sclerosis Registry is one of the oldest and most comprehensive MS registries in the world, providing valuable data for multiple research studies and demonstrating the prevalence and treatment outcomes of multiple sclerosis. Research results show that the average number of new cases of multiple sclerosis per year from 2010 to 2019 was 649, and a significant number of patients are receiving disease modifying therapy.
BRAIN AND BEHAVIOR
(2021)
Article
Orthopedics
Dennis Karimi, Soren Wacher Qvistgaard, Per Hviid Gundtoft, Stig Brorson, Bjarke Viberg
Summary: The overall incidence of humeral shaft fractures in Denmark remained stable from 1996 to 2018, with a majority of cases being females aged 50 years and above. Non-surgical treatment was the preferred primary treatment, and plate osteosynthesis became more popular than intramedullary nailing over time.
Article
Nutrition & Dietetics
Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyro, Gunnar Gislason, Augustin Scalbert, Anne Tjonneland, Jonathan M. Hodgson, Nicola P. Bondonno
Summary: Intake of flavonoids is inversely associated with the incidence of ischemic stroke, with moderate consumption of flavonoid-rich foods being beneficial for stroke prevention.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Julie Louise Munk Andersen, Kirsten Frederiksen, Johnni Hansen, Cecilie Kyro, Kim Overvad, Anne Tjonneland, Anja Olsen, Ole Raaschou-Nielsen
Summary: This study investigates the association between organic food consumption and cancer incidence. It finds no overall association between organic food intake and cancer. However, there is a lower incidence of stomach cancer and a higher incidence of non-Hodgkin lymphoma associated with organic food consumption. Similar patterns are observed for specific food groups.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Hye Yeon Koo, Su-Min Jeong, Mi Hee Cho, Sohyun Chun, Dong Wook Shin, Jinsung Park
Summary: Aspirin and metformin use may be associated with lower prostate cancer incidence and mortality, while statins are not associated with either.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Chin Sheng Teoh, Preethi Jeyabal, Stephanie M. Young, Vivien S. Y. Lim
Summary: The study on primary ophthalmic cancers in Singapore from 1996 to 2016 showed an overall increase in incidence, with a substantial rise in lymphomas, especially in patients aged 15 years and older. The most common types of ophthalmic cancers were retinoblastoma, lymphoma, and malignant melanoma.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2021)
Article
Anesthesiology
Rune P. Hasselager, Jesper Hallas, Ismail Gogenur
Summary: The study found a weak association between exposure to inhalation anaesthesia and increased risk of recurrence in patients undergoing colorectal cancer surgery. However, there was no significant association with all-cause mortality and disease-free survival.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Obstetrics & Gynecology
Sofie Lindquist, Susanne K. Kjaer, Vanna Albieri, Kirsten Frederiksen, Tatiana Hansen, Bugge Nohr, Allan Jensen
Summary: The use of most fertility drugs is not associated with an increased risk of thyroid cancer among infertile women. However, the use of progesterone may be modestly linked to an increased incidence of thyroid cancer and further research is needed to confirm this association.
HUMAN REPRODUCTION
(2022)
Article
Public, Environmental & Occupational Health
Christina Andersen, Inge dSchjodt, Anne Nakano, Soren Paaske Johnsen, Kenneth Egstrup, Brian B. Logstrup
Summary: The study examined the validity of the Danish Heart Failure Registry (DHFR) and found that it has a high degree of completeness and validity, making it a valuable tool for clinical epidemiological research in heart failure.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Oncology
Francois Lagace, Feras M. Ghazawi, Michelle Le, Evgeny Savin, Andrei Zubarev, Mathieu Powell, Linda Moreau, Denis Sasseville, Ioana Popa, Ivan Litvinov
Summary: Prostate cancer is the most common reportable malignancy in Canadian men. A retrospective analysis from 1992 to 2010 revealed an overall increasing trend in crude incidence rates, with peaks in 1993, 2001, and 2007. However, age-adjusted incidence rates did not show significant changes over time. National mortality rates also decreased during the same period, with certain provinces, cities, and areas having higher incidence/mortality rates than the national average.
Review
Chemistry, Medicinal
Jinjiang Jiang, Bo Chen, Bo Tang, Qiang Wei
Summary: Selenium plays a crucial role in prostate cancer research, involving prevention, development, and treatment. It has shown promise in combinatorial therapy and is associated with various cellular processes. Selenium holds potential as a trace mineral for prostate cancer prevention, development, treatment, and exploration of novel agents.
Article
Medicine, General & Internal
Nina McKinnon Edwards, Claus Varnum, Soren Overgaard, Lone Nikolajsen, Christian Fynbo Christiansen, Alma Becic Pedersen
Summary: In this study, the risk factors for new chronic opioid use in elderly patients who underwent hip fracture surgery were investigated. Several factors such as Body Mass Index, preoperative medication use, and presence of certain comorbidities were identified as risk factors for new chronic opioid use after surgery, providing valuable information for preoperative counseling and postoperative treatment tailoring.
Article
Public, Environmental & Occupational Health
Soren Viborg Vestergaard, Henrik Birn, Simon Kok Jensen, Henrik Toft Sorensen, Dorothea Nitsch, Christian Fynbo Christiansen
Summary: This study aimed to investigate the incidence, histopathology, and mortality of adult nephrotic syndrome over a 24-year period. The study found a slight increase in the incidence of adult nephrotic syndrome and a significant decrease in mortality. These findings may reflect changes in epidemiology or awareness and coding of nephrotic syndrome.
Article
Public, Environmental & Occupational Health
Cecilia Hvitfeldt Fuglsang, Istvan Bakos, Kristina Laugesen, Frederikke Schonfeldt Troelsen, Erzsebet Horvath-Puho, Henrik Toft Sorensen
Summary: This population-based cohort study in Denmark investigated the association between smoking during pregnancy and the risk of appendicitis in offspring. The results showed a slightly higher hazard rate for children of smoking mothers compared to nonsmokers. The association may be mediated by later-life exposures.
Article
Education & Educational Research
Kala M. Mehta, Karin Lottrup Petersen, Steve Goodman, Henrik Toft Sorensen, Martin Bogsted, Jeppe Dorup Olesen, Sylvia Burks, Richard E. Shaw, Jens Dahlgaard Hove, Jakob Ousager, Carlos Milla, Vibeke Andersen, Niels Ejskjaer, Vibeke Brix-Christensen, Shomit Ghose, Andreas Kjaer, Peter V. Chin-Hong
Summary: The Danish-American Research Exchange (DARE) program provides Danish medical students with the opportunity to collaborate and conduct biomedical research with US medical institutions. This program enhances students' research skills and interdisciplinary thinking, and encourages exploration of low-cost healthcare interventions. Analysis of the research outcomes and intentions of DARE alumni suggests that this medical student-initiated research model has positive effects on promoting binational collaboration in medicine.
BMC MEDICAL EDUCATION
(2023)
Article
Gastroenterology & Hepatology
Frederikke Schonfeldt Troelsen, Henrik Toft Sorensen, Lars Pedersen, Lone Dragnes Brix, Louise Bang Grode, Evelien Dekker, Rune Erichsen
Summary: This study investigated the plausible explanations for post-colonoscopy colorectal cancer (PCCRC) in a Danish Region using the World Endoscopy Organization algorithm, finding that most PCCRCs originate from possible missed lesions and incompletely resected lesions. These findings underscore the importance of quality assurance of colonoscopy procedures and polypectomy techniques.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ola Olen, Karin E. Smedby, Rune Erichsen, Lars Pedersen, Jonas Halfvarson, Asa Hallqvist-Everhov, Johan SWIBREG Study Grp, Johan Askling, Anders Ekbom, Michael C. Sachs, Henrik Toft Sorensen, Jonas F. Ludvigsson
Summary: Earlier studies on lymphoma risk in patients with inflammatory bowel disease (IBD) have provided varying estimates, but have been limited by detection biases, misclassification, and small sample sizes. Our binational cohort study found that the risk of lymphoma has increased in Crohn's disease (CD) patients over the past 20 years, but not in ulcerative colitis (UC) patients. The increase in risk was mainly driven by T-cell lymphomas and aggressive B-cell lymphomas.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Anne Gedebjerg, Mette Bjerre, Alisa Devedzic Kjaergaard, Jens Steen Nielsen, Jorgen Rungby, Ivan Brandslund, Michael Maeng, Henning Beck-Nielsen, Allan Vaag, Henrik Toft Sorensen, Troels Krarup Hansen, Reimar Wernich Thomsen
Summary: We investigated the relationship between hs-CRP and C-peptide in patients with recently diagnosed T2D and found that high levels of hs-CRP were associated with increased risk of CVEs and all-cause mortality. Patients with high levels of both biomarkers had the highest risk. These findings have important implications for early detection and prevention of deadly diseases beyond CVEs.
Article
Health Care Sciences & Services
Anders Hammerich Riis, Pia Kjaer Kristensen, Simon Meyer Lauritsen, Bo Thiesson, Marianne Johansson Jorgensen
Summary: This study developed an AI prediction model for potentially preventable hospitalizations and used explainable AI to identify predictors and their interaction. The best model had an AUC of 0.789 and a precision-recall AUC of 0.232. Age, prescription drugs for obstructive airway diseases, antibiotics, and use of municipality services were the most important predictors. There was an interaction between age and use of municipality services, suggesting a lower risk of hospitalization for citizens aged 75+ receiving municipality services.
Article
Endocrinology & Metabolism
N. R. Gadgaard, C. Varnum, R. G. H. H. Nelissen, C. Vandenbroucke-Grauls, H. T. Sorensen, A. B. Pedersen
Summary: The impact of comorbidity on infection risk among hip fracture patients is not clear, but a high incidence of infection was found. Comorbidity was identified as an important risk factor for infection up to 1 year after surgery. The results indicate a need for increased investment and support for patients with high comorbidity in pre- and postoperative programs.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Morten Schmidt, Lars Arendt-Nielsen, Ellen-Margrethe Hauge, Henrik Toft Sorensen, Lars Pedersen
Summary: This study investigated the dose dependency of diclofenac's cardiovascular risks by using Danish health registries and a target trial emulation design. The results showed that both high-dose and low-dose diclofenac users had a similar increased risk of cardiovascular events compared to non-users. This finding challenges the assumption that low-dose diclofenac is risk-neutral.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Anne Cathrine Baun Thuesen, Rasmus Tanderup Jensen, Henrik Maagensen, Maja Refshauge Kristiansen, Henrik Toft Sorensen, Allan Vaag, Henning Beck-Nielsen, Oluf B. Pedersen, Niels Grarup, Jens Steen Nielsen, Jorgen Rungby, Anette Prior Gjesing, Heidi Storgaard, Tina Vilsboll, Torben Hansen
Summary: This study investigated the glycemic phenotype and treatment response of patients with type 2 diabetes carrying rare GCK variants consistent with GCK-diabetes. Carriers of pathogenic and likely pathogenic variants had lower fasting glucose and C-peptide levels. Stopping medication did not lead to worsening of HbA1c or fasting glucose. Variants of uncertain significance should be interpreted carefully.
MOLECULAR GENETICS AND METABOLISM REPORTS
(2023)
Correction
Public, Environmental & Occupational Health
Dagrun Slettebo Daltveit, Kari Klungsoyr, Anders Engeland, Anders Ekbom, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Rebecca Troisi, Tone Bjorge
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Alma B. Pedersen, Nickolaj Risbo, George Kafatos, David Neasham, James O'Kelly, Vera Ehrenstein
Summary: The study found that persistence with initial treatment was highest after 1 year and decreased afterwards. Denosumab had the highest persistence, followed by alendronate. Several factors associated with treatment persistence were identified, some of which were the same regardless of the specific medication, which could help target subgroups of patients in terms of social and healthcare support.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Oncology
Jazmine Abril, Britton Trabert, Rebecca Troisi, Tom Grotmol, Anders Ekbom, Anders Engeland, Mika Gissler, Ingrid Glimelius, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Steinar Tretli, Tone Bjorge
Summary: This study examines the risk factors for uterine sarcoma and compares them with MMMTs and type I endometrial carcinomas. The results show that risk factors vary substantially between uterine sarcoma and MMMTs.
CANCER CAUSES & CONTROL
(2023)
Article
Clinical Neurology
Holly Elser, Erzsebet Horvath-Puho, Jaimie L. Gradus, Meghan L. Smith, Timothy L. Lash, M. Maria Glymour, Henrik Toft Sorensen, Victor W. Henderson
Summary: Late-life depressive symptoms are associated with subsequent dementia diagnosis and may be an early symptom or response to preclinical disease. Evaluating associations with early- and middle-life depression will help clarify whether depression influences dementia risk.
Article
Geriatrics & Gerontology
Lisa Fonss Rasmussen, Ishay Barat, Anders Hammerich Riis, Merete Gregersen, Louise Grode
Summary: This study aimed to evaluate the impact of a transitional care intervention on readmission rates among older medical inpatients. The results showed that there was no significant difference in readmission rates between the intervention group and the control group.
EUROPEAN GERIATRIC MEDICINE
(2023)