Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells

Molecular mechanism of action of metformin: old or new insights?

(2013) Graham Rena et al.   DIABETOLOGIA

Potential applications for biguanides in oncology

(2013) Michael Pollak   JOURNAL OF CLINICAL INVESTIGATION

Metformin Therapy and Risk of Cancer in Patients with Type 2 Diabetes: Systematic Review

(2013) Monica Franciosi et al.   PLoS One

Growth Signals, Inflammation, and Vascular Perturbations

(2012) Stephen D. Hursting et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of antioxidants in cancer therapy

(2012) Vanessa Fuchs-Tarlovsky   NUTRITION

Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth

(2011) G. Z. Rocha et al.   CLINICAL CANCER RESEARCH

Metformin reduces the stimulatory effect of obesity on in vivo Walker-256 tumor development and increases the area of tumor necrosis

(2011) Eveline Aparecida Isquierdo Fonseca et al.   LIFE SCIENCES

Sacrifice for survival

(2011) Nana-Maria Grüning et al.   NATURE

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Isolated and combined action of tamoxifen and metformin in wild-type, tamoxifen-resistant, and estrogen-deprived MCF-7 cells

(2010) Lev M. Berstein et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction-induced Longevity

(2009) Eric L. Greer et al.   Annals of the New York Academy of Sciences

Epidemiological and molecular mechanisms aspects linking obesity and cancer

(2009) Felipe Osório-Costa et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism

(2009) Fulvio Chiacchiera et al.   Autophagy

p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription

(2009) F Chiacchiera et al.   CELL DEATH AND DIFFERENTIATION

Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy

(2009) Leigh A. Cantrell et al.   GYNECOLOGIC ONCOLOGY

The Effects of Adiponectin and Metformin on Prostate and Colon Neoplasia Involve Activation of AMP-Activated Protein Kinase

(2008) M. Zakikhani et al.   Cancer Prevention Research

p21Cip1expression is increased in ambient oxygen, compared to estimated physiological (5%) levels in rat muscle precursor cell culture

(2008) S. J. Lees et al.   CELL PROLIFERATION

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

(2008) C. Algire et al.   ENDOCRINE-RELATED CANCER

FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells

(2008) Silvia Fernández de Mattos et al.   MOLECULAR CANCER THERAPEUTICS

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

Many forks in the path: cycling with FoxO

(2008) K K Ho et al.   ONCOGENE

Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy

(2008) Robert S. DiPaola et al.   PROSTATE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY