Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

Metformin: Multi-faceted protection against cancer

(2015) Sonia Del Barco et al.   Oncotarget

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1–PP2A protein complex

(2013) Sybille Krauß et al.   Nature Communications

Genomic Deletion of PTEN Is Associated with Tumor Progression and Early PSA Recurrence in ERG Fusion-Positive and Fusion-Negative Prostate Cancer

(2012) Antje Krohn et al.   AMERICAN JOURNAL OF PATHOLOGY

Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells

(2012) Qing-you Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Improving the management of patients with prostate cancer receiving long-term androgen deprivation therapy

(2012) C. Schulman et al.   BJU INTERNATIONAL

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study

(2012) Saroj Niraula et al.   BREAST CANCER RESEARCH AND TREATMENT

The influence of antidiabetic medications on the development and progression of prostate cancer

(2012) Anna Hitron et al.   Cancer Epidemiology

Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways

(2012) Gernot Walter et al.   CELL CYCLE

Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials

(2012) R. J. Stevens et al.   DIABETOLOGIA

Regulation of PP2A activity by Mid1 controls cranial neural crest speed and gangliogenesis

(2012) Elizabeth J. Latta et al.   MECHANISMS OF DEVELOPMENT

Cancer Risk Associated with Use of Metformin and Sulfonylurea in Type 2 Diabetes: A Meta-Analysis

(2012) D. Soranna et al.   ONCOLOGIST

Distinct perturbation of the translatome by the antidiabetic drug metformin

(2012) O. Larsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin enhances the antiproliferative and apoptotic effect of bicalutamide in prostate cancer

(2012) A J Colquhoun et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Metformin: An Emerging New Therapeutic Option for Targeting Cancer Stem Cells and Metastasis

(2012) Ramandeep Rattan et al.   Journal of Oncology

Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a

(2011) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

(2011) Charles E Massie et al.   EMBO JOURNAL

Protein Phosphatase 2A (PP2A)-specific Ubiquitin Ligase MID1 Is a Sequence-dependent Regulator of Translation Efficiency Controlling 3-Phosphoinositide-dependent Protein Kinase-1 (PDPK-1)

(2011) Beatriz Aranda-Orgillés et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress

(2010) Rishi Raj Chhipa et al.   CELLULAR SIGNALLING

Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone–binding globulin and androgen receptor polymorphisms

(2010) Marta Díaz et al.   FERTILITY AND STERILITY

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection

(2010) Huajie Bu et al.   PROSTATE

Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cells

(2009) Tisheeka R. Graham et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin use and prostate cancer in Caucasian men: results from a population-based case–control study

(2009) Jonathan L. Wright et al.   CANCER CAUSES & CONTROL

Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells

(2009) Meng-Lei Zhu et al.   FASEB JOURNAL

Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells

(2009) J Zhou et al.   ONCOGENE

The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex

(2008) Beatriz Aranda-Orgillés et al.   HUMAN GENETICS

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE