The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells

C/EBPα and C/EBPβ binding proteins modulate hepatocyte apoptosis through iNOS signaling pathway

(2011) Kewei Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation

(2011) Jenny Barthson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide

(2011) Veronica Ramberg et al.   Journal of Neuroinflammation

Egr-1 Transactivates Bim Gene Expression to Promote Neuronal Apoptosis

(2011) B. Xie et al.   JOURNAL OF NEUROSCIENCE

Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes

(2011) Frank Waldron-Lynch et al.   NATURE REVIEWS DRUG DISCOVERY

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

Insulitis in human type 1 diabetes

(2011) Peter In't Veld   Islets

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance

(2011) Maikel L. Colli et al.   PLoS Pathogens

Autophagy in health and disease. 4. The role of pancreatic β-cell autophagy in health and diabetes

(2010) Yoshio Fujitani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

(2010) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

Islet inflammation and CXCL10 in recent-onset type 1 diabetes

(2010) B. O. Roep et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Stopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man

(2010) J. S. Skyler et al.   DIABETES

Genetics of Type 1 Diabetes: What's Next?

(2010) F. Pociot et al.   DIABETES

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis

(2010) F. Allagnat et al.   DIABETOLOGIA

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

(2010) Esteban N. Gurzov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation

(2010) Fabrice Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status

(2010) Ilir Mehmeti et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

C/EBP-β Regulates Endoplasmic Reticulum Stress–Triggered Cell Death in Mouse and Human Models

(2010) Ofir Meir et al.   PLoS One

C/EBP  targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression

(2010) S. A. Pawar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta cell apoptosis in diabetes

(2009) Helen E. Thomas et al.   APOPTOSIS

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

Cytokines Interleukin-1  and Tumor Necrosis Factor-  Regulate Different Transcriptional and Alternative Splicing Networks in Primary  -Cells

(2009) F. Ortis et al.   DIABETES

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

(2009) M. D. McKenzie et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice

(2009) Tomokazu Matsuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Role for c-Rel and C/EBP /  in TLR-Mediated Induction of Proinflammatory Cytokines

(2009) Y.-C. Lu et al.   JOURNAL OF IMMUNOLOGY

CCAAT/enhancer binding protein delta in microglial activation

(2009) Aroa Ejarque-Ortiz et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

(2009) Vladimir Litvak et al.   NATURE IMMUNOLOGY

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic β-cells

(2008) Taila Hartley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cytokine signalling in the β-cell: a dual role for IFNγ: Figure 1

(2008) Conny Gysemans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Use of a systems biology approach to understand pancreatic β-cell death in Type 1 diabetes

(2008) Decio L. Eizirik et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

(2008) A. Gowda et al.   BLOOD

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

(2008) A. P. Martin et al.   DIABETES

Viral Trigger for Type 1 Diabetes: Pros and Cons

(2008) C. M. Filippi et al.   DIABETES

Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells

(2008) F. Ortis et al.   DIABETOLOGIA

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

Epigenetic Silencing of CCAAT/Enhancer-binding Protein δ Activity by YY1/Polycomb Group/DNA Methyltransferase Complex

(2008) Chiung-Yuan Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Role of the transcriptional factor C/EBPβ in free fatty acid-elicited β-cell failure

(2008) Valérie Plaisance et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autophagy Provides Nutrients but Can Lead to Chop-dependent Induction of Bim to Sensitize Growth Factor–deprived Cells to Apoptosis

(2008) Brian J. Altman et al.   MOLECULAR BIOLOGY OF THE CELL

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells

(2008) Esteban N. Gurzov et al.   PLoS One