Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

Early Resolution of Acute Immune Activation and Induction of PD-1 in SIV-Infected Sooty Mangabeys Distinguishes Nonpathogenic from Pathogenic Infection in Rhesus Macaques

(2014) J. D. Estes et al.   JOURNAL OF IMMUNOLOGY

Virus-Encoded TLR Ligands Reveal Divergent Functional Responses of Mononuclear Phagocytes in Pathogenic Simian Immunodeficiency Virus Infection

(2013) E. R. Wonderlich et al.   JOURNAL OF IMMUNOLOGY

Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation

(2012) T. H. Vanderford et al.   BLOOD

Pivotal role of M-DC8+ monocytes from viremic HIV-infected patients in TNF  overproduction in response to microbial products

(2012) C.-A. Dutertre et al.   BLOOD

SIV Infection Induces Accumulation of Plasmacytoid Dendritic Cells in the Gut Mucosa

(2012) R. K. Reeves et al.   JOURNAL OF INFECTIOUS DISEASES

Interferon-Alpha Administration Enhances CD8+ T Cell Activation in HIV Infection

(2012) Maura Manion et al.   PLoS One

Natural SIV Hosts: Showing AIDS the Door

(2012) Ann Chahroudi et al.   SCIENCE

Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis

(2011) A. Boasso et al.   BLOOD

Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques

(2011) S. Kwa et al.   BLOOD

Blocking Type I Interferon Production: A New Therapeutic Option to Reduce the HIV-1-Induced Immune Activation

(2011) Moritz Ries et al.   Clinical & Developmental Immunology

Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs

(2011) Daniela Hackl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α–producing and partially matured phenotype

(2011) Meagan O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting HIV-1 innate immune responses therapeutically

(2011) Rada Ellegård et al.   Current Opinion in HIV and AIDS

Generalized immune activation and innate immune responses in simian immunodeficiency virus infection

(2011) Steven E. Bosinger et al.   Current Opinion in HIV and AIDS

Induction and function of type I and III interferon in response to viral infection

(2011) David E Levy et al.   Current Opinion in Virology

The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point?

(2011) Peter D. Katsikis et al.   PLoS Pathogens

Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual

(2010) Melissa Swiecki et al.   IMMUNITY

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

(2010) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-α Produces Significant Decreases in HIV Load

(2010) Jorge A. Tavel et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Plasmacytoid dendritic cells in HIV infection: striking a delicate balance

(2010) Patricia Fitzgerald-Bocarsly et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase

(2010) Kiran D. Mir et al.   MICROBES AND INFECTION

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

(2010) Jacob D. Estes et al.   PLoS Pathogens

Immune activation and AIDS pathogenesis

(2009) Donald L Sodora et al.   AIDS

Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-  expression

(2009) M. Nascimbeni et al.   BLOOD

Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant

(2009) M. Paula Longhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Surface phenotype and rapid quantification of blood dendritic cell subsets in the rhesus macaque

(2009) Kevin N. Brown et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Nonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase

(2009) L. Campillo-Gimenez et al.   JOURNAL OF VIROLOGY

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

Rapid Influx and Death of Plasmacytoid Dendritic Cells in Lymph Nodes Mediate Depletion in Acute Simian Immunodeficiency Virus Infection

(2009) Kevin N. Brown et al.   PLoS Pathogens

Transcriptional Profiling in Pathogenic and Non-Pathogenic SIV Infections Reveals Significant Distinctions in Kinetics and Tissue Compartmentalization

(2009) Sharon Lederer et al.   PLoS Pathogens

Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression

(2008) B. Malleret et al.   BLOOD

Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections

(2008) Judith N Mandl et al.   NATURE MEDICINE

HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype

(2008) S. Fiorentini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic innate immune activation as a cause of HIV-1 immunopathogenesis

(2007) Adriano Boasso et al.   CLINICAL IMMUNOLOGY