Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells

Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2

(2017) Wei Wang et al.   NEUROBIOLOGY OF AGING

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

(2016) G. Ito et al.   BIOCHEMICAL JOURNAL

Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease

(2016) Kyle B. Fraser et al.   MOVEMENT DISORDERS

Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019SLRRK2carriers

(2016) Kyle B. Fraser et al.   NEUROLOGY

shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

(2016) Susana A. Gonçalves et al.   PLoS Genetics

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation

(2016) E. Lobbestael et al.   Scientific Reports

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

(2016) Tomoki Kuwahara et al.   Scientific Reports

LRRK2 dephosphorylation increases its ubiquitination

(2015) Jing Zhao et al.   BIOCHEMICAL JOURNAL

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

(2015) Y.-C. Lai et al.   EMBO JOURNAL

An early endosome regulator, Rab5b, is an LRRK2 kinase substrate

(2015) Hye Jin Yun et al.   JOURNAL OF BIOCHEMISTRY

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor

(2015) John M. Hatcher et al.   ACS Medicinal Chemistry Letters

Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with α-Synuclein Pathology

(2014) Gabrielle R. Wilson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease

(2014) Ian Martin et al.   CELL

Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China

(2014) D Wang et al.   GENES AND IMMUNITY

The small GTPase Rab11 co-localizes with  -synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity

(2014) O. Chutna et al.   HUMAN MOLECULAR GENETICS

Abnormal visual gain control in a Parkinson's disease model

(2014) F. Afsari et al.   HUMAN MOLECULAR GENETICS

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

(2014) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Rab10-mediated Endocytosis of the Hyaluronan Synthase HAS3 Regulates Hyaluronan Synthesis and Cell Adhesion to Collagen

(2014) Ashik Jawahar Deen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

(2014) Jaclyn L. Henderson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

(2014) Lauran Reyniers et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

(2014) Guowei Yin et al.   NEUROBIOLOGY OF DISEASE

LRRK2 exonic variants and risk of multiple system atrophy

(2014) M. G. Heckman et al.   NEUROLOGY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Identification of Significant Features by the Global Mean Rank Test

(2014) Martin Klammer et al.   PLoS One

LRRK2 Transport Is Regulated by Its Novel Interacting Partner Rab32

(2014) Dieter Waschbüsch et al.   PLoS One

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status

(2014) April Reynolds et al.   Frontiers in Molecular Neuroscience

LRRK2 secretion in exosomes is regulated by 14-3-3

(2013) K. B. Fraser et al.   HUMAN MOLECULAR GENETICS

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

(2013) Anthony A. Estrada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1

(2013) Gregory C. Luerman et al.   JOURNAL OF NEUROCHEMISTRY

Integrated proteomic analysis of post-translational modifications by serial enrichment

(2013) Philipp Mertins et al.   NATURE METHODS

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis

(2013) Daniel Ness et al.   PLoS One

Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus

(2013) Daniah Trabzuni et al.   PLoS One

Correction: Leucine and HMB Differentially Modulate Proteasome System in Skeletal Muscle under Different Sarcopenic Conditions

(2013) Igor L. Baptista et al.   PLoS One

GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

(2012) Alastair D. Reith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

(2012) Jinwei Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

(2012) Lore Delbroek et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

LRRK2 expression is enriched in the striosomal compartment of mouse striatum

(2012) Wim Mandemakers et al.   NEUROBIOLOGY OF DISEASE

Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation

(2012) Spencer B. Hermanson et al.   PLoS One

Phosphorylation of 4E-BP1 in the Mammalian Brain Is Not Altered by LRRK2 Expression or Pathogenic Mutations

(2012) Alzbeta Trancikova et al.   PLoS One

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

(2012) Z. Sheng et al.   Science Translational Medicine

Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity

(2011) Elena V. Nikonova et al.   HUMAN MOLECULAR GENETICS

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

(2011) Martin C. Herzig et al.   HUMAN MOLECULAR GENETICS

Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis

(2011) Junji Umeno et al.   INFLAMMATORY BOWEL DISEASES

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition

(2011) Elizabeth A. Doggett et al.   JOURNAL OF NEUROCHEMISTRY

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study

(2011) Owen A Ross et al.   LANCET NEUROLOGY

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

(2011) Xianming Deng et al.   Nature Chemical Biology

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

(2011) Jonathan Thévenet et al.   PLoS One

Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells

(2011) Yuexi Wang et al.   PROTEOMICS

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis

(2010) James H. Soper et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation

(2010) Makoto Kubo et al.   JOURNAL OF NEUROIMMUNOLOGY

A QUICK Screen for Lrrk2 Interaction Partners – Leucine-rich Repeat Kinase 2 is Involved in Actin Cytoskeleton Dynamics

(2010) Andrea Meixner et al.   MOLECULAR & CELLULAR PROTEOMICS

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

(2010) Stephan Gehrke et al.   NATURE

Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus

(2010) E.- K. Tan et al.   NEUROLOGY

Signal Transduction Protein Array Analysis Links LRRK2 to Ste20 Kinases and PKC Zeta That Modulate Neuronal Plasticity

(2010) Susanne Zach et al.   PLoS One

Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane

(2010) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

(2009) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Rab11a and HSP90 Regulate Recycling of Extracellular  -Synuclein

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rab10 in insulin-stimulated GLUT4 translocation

(2008) Hiroyuki Sano et al.   BIOCHEMICAL JOURNAL

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson’s disease

(2008) M. Westerlund et al.   NEUROSCIENCE

Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra

(2008) Baek-Soo Han et al.   NEUROSCIENCE LETTERS