Abnormal visual gain control in a Parkinson's disease model

Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy

(2013) Samantha Hindle et al.   HUMAN MOLECULAR GENETICS

Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation

(2013) Angelique C. Paulk et al.   JOURNAL OF NEUROPHYSIOLOGY

Rhodopsin homeostasis and retinal degeneration: lessons from the fly

(2013) Bo Xiong et al.   TRENDS IN NEUROSCIENCES

parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress

(2012) A. Vincent et al.   HUMAN MOLECULAR GENETICS

Dynamics of Normalization Underlying Masking in Human Visual Cortex

(2012) J. J. Tsai et al.   JOURNAL OF NEUROSCIENCE

Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision

(2012) C. R. Jackson et al.   JOURNAL OF NEUROSCIENCE

AMP Kinase Activation Mitigates Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease

(2012) C.-H. Ng et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

(2012) Samer Matta et al.   NEURON

Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease

(2012) Byoung Dae Lee et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Contrast gain control abnormalities in idiopathic generalized epilepsy

(2011) Jeffrey J. Tsai et al.   ANNALS OF NEUROLOGY

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

(2011) Zhaohui Liu et al.   HUMAN MOLECULAR GENETICS

Reward Value-Based Gain Control: Divisive Normalization in Parietal Cortex

(2011) K. Louie et al.   JOURNAL OF NEUROSCIENCE

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

(2011) Xianming Deng et al.   Nature Chemical Biology

LRRK2 Kinase Regulates Synaptic Morphology through Distinct Substrates at the Presynaptic and Postsynaptic Compartments of the Drosophila Neuromuscular Junction

(2010) S. Lee et al.   JOURNAL OF NEUROSCIENCE

The visual attractor illusion

(2010) T. Makovski et al.   JOURNAL OF VISION

Parkinson's disease: a model dilemma

(2010) M. Flint Beal   NATURE

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

(2010) Byoung Dae Lee et al.   NATURE MEDICINE

Stimulus-driven competition in a cholinergic midbrain nucleus

(2010) Ali Asadollahi et al.   NATURE NEUROSCIENCE

Divisive Normalization in Olfactory Population Codes

(2010) Shawn R. Olsen et al.   NEURON

Design Principles of Insect and Vertebrate Visual Systems

(2010) Joshua R. Sanes et al.   NEURON

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The retina in Parkinson's disease

(2009) N. K. Archibald et al.   BRAIN

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

Complex Dynamics of V1 Population Responses Explained by a Simple Gain-Control Model

(2009) Yiu Fai Sit et al.   NEURON

Representation of Concurrent Stimuli by Population Activity in Visual Cortex

(2009) Laura Busse et al.   NEURON

The Normalization Model of Attention

(2009) John H. Reynolds et al.   NEURON

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

Distinct Roles for Two Histamine Receptors (hclA and hclB) at the Drosophila Photoreceptor Synapse

(2008) A. Pantazis et al.   JOURNAL OF NEUROSCIENCE

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

(2008) Danling Wang et al.   Molecular Neurodegeneration

Assessing fetal nerve cell grafts in Parkinson's disease

(2008) Heiko Braak et al.   NATURE MEDICINE

A Drosophila model for LRRK2-linked parkinsonism

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA