Chemokines, costimulatory molecules and fusion proteins for the immunotherapy of solid tumors

Improving cancer immunotherapy by targeting tumor-induced immune suppression

(2011) Trina J. Stewart et al.   CANCER AND METASTASIS REVIEWS

A New Mechanism for Blocking Myeloid-Derived Suppressor Cells by CpG

(2011) M. G. Lechner et al.   CLINICAL CANCER RESEARCH

Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines

(2011) Melissa G Lechner et al.   Journal of Translational Medicine

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

(2011) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel CCL21-Vault Nanocapsule Intratumoral Delivery Inhibits Lung Cancer Growth

(2011) Upendra K. Kar et al.   PLoS One

Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study

(2010) S. J. O'Day et al.   ANNALS OF ONCOLOGY

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

(2010) Xueqing Sun et al.   CANCER AND METASTASIS REVIEWS

CXCL12, CXCR4 and CXCR7 expression in brain metastases

(2010) Andrea Salmaggi et al.   CANCER BIOLOGY & THERAPY

Chemokines

(2010) Steven M. Dubinett et al.   CANCER JOURNAL

Therapeutic effect of MIP-1α-recruited dendritic cells on preestablished solid and metastatic tumors

(2010) Qi Cao et al.   CANCER LETTERS

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation

(2010) Theresa Placke et al.   Clinical & Developmental Immunology

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Plerixafor: A chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation after high-dose chemotherapy for non-hodgkin's lymphoma or multiple myeloma

(2010) Michael Steinberg et al.   CLINICAL THERAPEUTICS

CCL5 as an adjuvant for cancer immunotherapy

(2010) Natalia Lapteva et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Chemokine–chemokine receptors in cancer immunotherapy

(2010) Trina J Stewart et al.   Immunotherapy

Vaccines against Human Carcinomas: Strategies to Improve Antitumor Immune Responses

(2010) Claudia Palena et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adjuvant Therapy With Agonistic Antibodies to CD134 (OX40) Increases Local Control After Surgical or Radiation Therapy of Cancer in Mice

(2010) Michael J. Gough et al.   JOURNAL OF IMMUNOTHERAPY

High-dose Interleukin-2 Can Produce a High Rate of Response and Durable Remissions in Appropriately Selected Patients With Metastatic Renal Cancer

(2010) Alaaeldin Shablak et al.   JOURNAL OF IMMUNOTHERAPY

The multiple faces of CXCL12 (SDF-1α) in the regulation of immunity during health and disease

(2010) Nathan Karin   JOURNAL OF LEUKOCYTE BIOLOGY

Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy

(2010) Xinmei Zhu et al.   JOURNAL OF NEURO-ONCOLOGY

Multiple Roles of Chemokine (C-C Motif) Ligand 2 in Promoting Prostate Cancer Growth

(2010) J. Zhang et al.   JNCI-Journal of the National Cancer Institute

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

Adjuvants for cancer vaccines

(2010) Thomas W. Dubensky et al.   SEMINARS IN IMMUNOLOGY

The Emerging Toxicity Profiles of Anti–CTLA-4 Antibodies Across Clinical Indications

(2010) Anna Maria Di Giacomo et al.   SEMINARS IN ONCOLOGY

Update on Immunologic Therapy With Anti–CTLA-4 Antibodies in Melanoma: Identification of Clinical and Biological Response Patterns, Immune-Related Adverse Events, and Their Management

(2010) Katharina C. Kaehler et al.   SEMINARS IN ONCOLOGY

Anti–CTLA-4 Antibody Therapy: Immune Monitoring During Clinical Development of a Novel Immunotherapy

(2010) Margaret K. Callahan et al.   SEMINARS IN ONCOLOGY

Signaling Through OX40 Enhances Antitumor Immunity

(2010) Shawn M. Jensen et al.   SEMINARS IN ONCOLOGY

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

CCL2 Blockade Augments Cancer Immunotherapy

(2009) Z. G. Fridlender et al.   CANCER RESEARCH

Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+T cells with tumor regression

(2009) Naoko Imai et al.   CANCER SCIENCE

The chemokine system in cancer biology and therapy

(2009) Alberto Mantovani et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo

(2009) William L. Redmond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The role of stromal-derived factor-1 — CXCR7 axis in development and cancer

(2009) Radoslaw B. Maksym et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma

(2009) K Aravindaram et al.   GENE THERAPY

OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis

(2009) Daniel Hirschhorn-Cymerman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fc-mOX40L Fusion Protein Produces Complete Remission and Enhanced Survival in 2 Murine Tumor Models

(2009) Rebecca E. Sadun et al.   JOURNAL OF IMMUNOTHERAPY

Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma

(2009) Antoni Ribas et al.   Journal of Translational Medicine

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

(2009) Silvia Buonamici et al.   NATURE

The cancer vaccine roller coaster

(2009) Bruce Goldman et al.   NATURE BIOTECHNOLOGY

TARC and RANTES enhance antitumor immunity induced by the GM-CSF-transduced tumor vaccine in a mouse tumor model

(2008) Hiroyuki Inoue et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity

(2008) John S. Cho et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The inflammatory chemokines CCL2 and CCL5 in breast cancer

(2008) Gali Soria et al.   CANCER LETTERS

Regulatory T Cell-Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

(2008) H. Nishikawa et al.   CANCER RESEARCH

Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer

(2008) Hiroshi Yokouchi et al.   CANCER SCIENCE

Construction and Preclinical Characterization of Fc-mGITRL for the Immunotherapy of Cancer

(2008) P. Hu et al.   CLINICAL CANCER RESEARCH

Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape

(2008) Jessica B. Katz et al.   IMMUNOLOGICAL REVIEWS

The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer

(2008) David H. Lynch   IMMUNOLOGICAL REVIEWS

Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours

(2008) Jinhua Piao et al.   IMMUNOLOGY

CCR7 regulates B16 murine melanoma cell tumorigenesis in skin

(2008) Lei Fang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells

(2008) Tanja Nicole Hartmann et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in Non-Small Cell Lung Cancer

(2008) Felicita Baratelli et al.   Journal of Translational Medicine

How tumours escape mass destruction

(2008) T J Stewart et al.   ONCOGENE

Vaccination with combination of Fit3L and RANTES in a DNA prime-protein boost regimen elicits strong cell-mediated immunity and antitumor effect

(2008) Shuxia Song et al.   VACCINE