Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect

Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1

(2016) Sarah Welbourn et al.   VIROLOGY

Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli

(2016) Christina M Zimanyi et al.   eLife

Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592

(2015) Chenxiang Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain

(2015) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

(2015) Kyle J. Seamon et al.   NUCLEIC ACIDS RESEARCH

SAMHD1 specifically restricts retroviruses through its RNase activity

(2015) Jongsu Choi et al.   Retrovirology

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

(2015) Laurence H. Arnold et al.   PLoS Pathogens

The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP

(2015) Chun-Feng Zhu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Continuous Enzyme-Coupled Assay for Triphosphohydrolase Activity of HIV-1 Restriction Factor SAMHD1

(2014) Laurence H. Arnold et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Basis of Allosteric Activation of Sterile α Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates

(2014) Leonardus M. I. Koharudin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

(2014) Jeongmin Ryoo et al.   NATURE MEDICINE

Structural basis of cellular dNTP regulation by SAMHD1

(2014) X. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

(2014) E. C. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1

(2014) Thomas Fricke et al.   Retrovirology

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

(2013) Tommy E. White et al.   Cell Host & Microbe

GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1

(2013) Sarah M. Amie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

(2013) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction

(2013) Natalia Beloglazova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-stranded nucleic acids promote SAMHD1 complex formation

(2013) Victoria Tüngler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Restriction of Virus Infection but Not Catalytic dNTPase Activity Is Regulated by Phosphorylation of SAMHD1

(2013) S. Welbourn et al.   JOURNAL OF VIROLOGY

Mechanism of allosteric activation of SAMHD1 by dGTP

(2013) Xiaoyun Ji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

(2013) E. Franzolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1

(2013) Alberto Brandariz-Nuñez et al.   Retrovirology

Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1

(2013) Ke Zhao et al.   Cell Reports

Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1

(2013) Alexandra Cribier et al.   Cell Reports

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

(2012) Adriana Goncalves et al.   HUMAN MUTATION

Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived Macrophages

(2012) Baek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

(2012) Benjamin Descours et al.   Retrovirology

Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1

(2012) Tommy E. White et al.   VIROLOGY

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection

(2011) André Berger et al.   PLoS Pathogens

A two-dimensional spectrum analysis for sedimentation velocity experiments of mixtures with heterogeneity in molecular weight and shape

(2009) Emre Brookes et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Vpx Is Critical for Reverse Transcription of the Human Immunodeficiency Virus Type 2 Genome in Macrophages

(2008) M. Fujita et al.   JOURNAL OF VIROLOGY