MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1

Novel Inhibitor Binding Site Discovery on HIV-1 Capsid N-Terminal Domain by NMR and X-ray Crystallography

(2013) Nathalie Goudreau et al.   ACS Chemical Biology

A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallizationviacompound-mediated dimerization

(2013) Christopher T. Lemke et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mechanics of Dynamin-Mediated Membrane Fission

(2013) Sandrine Morlot et al.   Annual Review of Biophysics

GTP-Dependent Membrane Fusion

(2013) James A. McNew et al.   Annual Review of Cell and Developmental Biology

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

(2013) Louie Lamorte et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dynamins Are Forever: MxB Inhibits HIV-1

(2013) Otto Haller   Cell Host & Microbe

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

(2013) Tommy E. White et al.   Cell Host & Microbe

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection

(2013) Zhenlong Liu et al.   Cell Host & Microbe

An evolutionary perspective on the broad antiviral specificity of MxA

(2013) Patrick S Mitchell et al.   CURRENT OPINION IN MICROBIOLOGY

The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm

(2013) Han Xiao et al.   JOURNAL OF VIROLOGY

Human Cytosolic Extracts Stabilize the HIV-1 Core

(2013) T. Fricke et al.   JOURNAL OF VIROLOGY

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

(2013) Thomas Fricke et al.   Retrovirology

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

(2013) Alberto De Iaco et al.   Retrovirology

Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction

(2013) Yang Yang et al.   VIROLOGY

MxA inhibits hepatitis B virus replication by interaction with hepatitis B core antigen

(2012) Ning Li et al.   HEPATOLOGY

Myxovirus Resistance Gene A (MxA) Expression Suppresses Influenza A Virus Replication in Alpha Interferon-Treated Primate Cells

(2012) S. R. Matzinger et al.   JOURNAL OF VIROLOGY

Inhibition of Reverse Transcriptase Activity Increases Stability of the HIV-1 Core

(2012) Y. Yang et al.   JOURNAL OF VIROLOGY

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

(2012) Amanda J. Price et al.   PLoS Pathogens

RING Domain Mutations Uncouple TRIM5  Restriction of HIV-1 from Inhibition of Reverse Transcription and Acceleration of Uncoating

(2011) A. Roa et al.   JOURNAL OF VIROLOGY

Contribution of E3-Ubiquitin Ligase Activity to HIV-1 Restriction by TRIM5 rh: Structure of the RING Domain of TRIM5 

(2011) M. Lienlaf et al.   JOURNAL OF VIROLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

APOBEC3A Is a Specific Inhibitor of the Early Phases of HIV-1 Infection in Myeloid Cells

(2011) Gregory Berger et al.   PLoS Pathogens

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

Dynamin-like MxA GTPase: Structural Insights into Oligomerization and Implications for Antiviral Activity

(2010) Otto Haller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human MxA Protein: An Interferon-Induced Dynamin-Like GTPase with Broad Antiviral Activity

(2010) Otto Haller et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization

(2010) J. Shi et al.   JOURNAL OF VIROLOGY

Structural basis of oligomerization in the stalk region of dynamin-like MxA

(2010) Song Gao et al.   NATURE

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

(2010) Wade S. Blair et al.   PLoS Pathogens

Characterization of the Behavior of Functional Viral Genomes during the Early Steps of Human Immunodeficiency Virus Type 1 Infection

(2009) V. Arfi et al.   JOURNAL OF VIROLOGY

Inhibition of a Large Double-Stranded DNA Virus by MxA Protein

(2008) C. L. Netherton et al.   JOURNAL OF VIROLOGY

A human TRIM5α B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus

(2008) Felipe Diaz-Griffero et al.   VIROLOGY