Molecular architecture and regulation of BCL10-MALT1 filaments

Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome

(2018) Liron David et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BCL10 – Bridging CARDs to Immune Activation

(2018) Torben Gehring et al.   Frontiers in Immunology

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition

(2017) Maureen Bardet et al.   IMMUNOLOGY AND CELL BIOLOGY

Germline hypomorphic CARD11 mutations in severe atopic disease

(2017) Chi A Ma et al.   NATURE GENETICS

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome

(2016) Isabel Meininger et al.   BIOLOGICAL CHEMISTRY

Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling

(2016) Yong-Kang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells

(2016) Isabel Meininger et al.   Nature Communications

The paracaspase MALT1: biological function and potential for therapeutic inhibition

(2015) Maike Jaworski et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation

(2015) Nathalie Knies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity

(2014) Juan Manuel Torres et al.   JOURNAL OF CLINICAL INVESTIGATION

MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes

(2014) Mathijs Baens et al.   PLoS One

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

(2014) Hui Xu et al.   eLife

Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase

(2013) Florian Schlauderer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency

(2013) Johann Greil et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects

(2013) Polina Stepensky et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency

(2013) Haifa H. Jabara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Combined immunodeficiency associated with homozygous MALT1 mutations

(2013) Margaret L. McKinnon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

SPRING – An image processing package for single-particle based helical reconstruction from electron cryomicrographs

(2013) Ambroise Desfosses et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

The protease activity of the paracaspase MALT1 is controlled by monoubiquitination

(2013) Christiane Pelzer et al.   NATURE IMMUNOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Novel Disulfide Bond-Mediated Dimerization of the CARD Domain Was Revealed by the Crystal Structure of CARMA1 CARD

(2013) Tae-ho Jang et al.   PLoS One

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

(2012) Lorena Fontan et al.   CANCER CELL

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

Selective Autophagy of the Adaptor Protein Bcl10 Modulates T Cell Receptor Activation of NF-κB

(2012) Suman Paul et al.   IMMUNITY

Regulation of NF-κB by the CARD proteins

(2012) Changying Jiang et al.   IMMUNOLOGICAL REVIEWS

Congenital B cell lymphocytosis explained by novel germlineCARD11mutations

(2012) Andrew L. Snow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural Insights into the Assembly of CARMA1 and BCL10

(2012) Siwei Li et al.   PLoS One

NF-κB Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-κB Activation

(2011) Kamyar Hadian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomeric Structure of the MALT1 Tandem Ig-Like Domains

(2011) Liyan Qiu et al.   PLoS One

Antigen Receptor Signaling to NF- B via CARMA1, BCL10, and MALT1

(2010) M. Thome et al.   Cold Spring Harbor Perspectives in Biology

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Multiple Protein Domains Mediate Interaction between Bcl10 and MALT1

(2008) Felicia D. Langel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF- B activation

(2008) C.-J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

(2008) G. Lenz et al.   SCIENCE