From definition to implementation: a cross-industry perspective of past, current and future MIST strategies
Published 2011 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
From definition to implementation: a cross-industry perspective of past, current and future MIST strategies
Authors
Keywords
-
Journal
XENOBIOTICA
Volume 41, Issue 8, Pages 605-622
Publisher
Informa UK Limited
Online
2011-03-29
DOI
10.3109/00498254.2011.562330
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC–HR-MS
- (2010) David Falck et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Determination of Exposure Multiples of Human Metabolites for MIST Assessment in Preclinical Safety Species without Using Reference Standards or Radiolabeled Compounds
- (2010) Shuguang Ma et al. CHEMICAL RESEARCH IN TOXICOLOGY
- A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments
- (2010) H. Gao et al. DRUG METABOLISM AND DISPOSITION
- Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery
- (2010) A. Mutlib et al. DRUG METABOLISM AND DISPOSITION
- Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
- (2010) W. W. Wang et al. DRUG METABOLISM AND DISPOSITION
- Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance
- (2010) Hongbin Yu et al. Expert Opinion on Drug Metabolism & Toxicology
- Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR
- (2010) Jon S.B. de Vlieger et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- A radiocalibration method with pseudo internal standard to estimate circulating metabolite concentrations
- (2010) Ping Yi et al. Bioanalysis
- Addressing metabolite safety during first-in-man studies using14C-labeled drug and accelerator mass spectrometry
- (2010) Graham Lappin et al. Bioanalysis
- NMR spectroscopy as a tool to close the gap on metabolite characterization under MIST
- (2010) Janet Caceres-Cortes et al. Bioanalysis
- Novel MS solutions inspired by MIST
- (2010) Ragu Ramanathan et al. Bioanalysis
- Best practices in a tiered approach to metabolite quantification: views and recommendations of the European Bioanalysis Forum
- (2010) Philip Timmerman et al. Bioanalysis
- An Accurate-Mass-Based Spectral-Averaging Isotope-Pattern-Filtering Algorithm for Extraction of Drug Metabolites Possessing a Distinct Isotope Pattern from LC-MS Data
- (2009) Peijuan Zhu et al. ANALYTICAL CHEMISTRY
- Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations
- (2009) Mingshe Zhu et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Safety Assessment of Drug Metabolites: Implications of Regulatory Guidance and Potential Application of Genetically Engineered Mouse Models that Express Human P450s
- (2009) Mark W. Powley et al. CHEMICAL RESEARCH IN TOXICOLOGY
- A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development
- (2009) Don Walker et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Predicting Circulating Human Metabolites: How Good Are We?
- (2009) Shelby Anderson et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites
- (2009) Deepak Dalvie et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment
- (2009) Dennis A. Smith et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries
- (2009) A. Srivastava et al. DRUG METABOLISM AND DISPOSITION
- In vivomodeling of human liver for pharmacological study using humanized mouse
- (2009) Katsutoshi Yoshizato et al. Expert Opinion on Drug Metabolism & Toxicology
- Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage
- (2009) Gabriella Brolén et al. JOURNAL OF BIOTECHNOLOGY
- Human embryonic stem cell technologies and drug discovery
- (2009) Janne Jensen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices
- (2009) Peijuan Zhu et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Metabolites in safety testing
- (2009) Timothy W Robison et al. Bioanalysis
- Metabolite quantitation: detector technology and MIST implications
- (2009) Pat Wright et al. Bioanalysis
- Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards
- (2008) Karthick Vishwanathan et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing
- (2008) Robert Espina et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Metabolism and Disposition of Fluticasone Furoate, an Enhanced-Affinity Glucocorticoid, in Humans
- (2008) S. C. Hughes et al. DRUG METABOLISM AND DISPOSITION
- Comparison of LC-NMR and conventional NMR for structure elucidation in drug metabolism studies
- (2008) Gregory S Walker et al. Expert Opinion on Drug Metabolism & Toxicology
- Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics
- (2008) Graham Lappin et al. Expert Opinion on Drug Metabolism & Toxicology
- Improved liquid chromatography—Online radioactivity detection for metabolite profiling
- (2008) Filip Cuyckens et al. JOURNAL OF CHROMATOGRAPHY A
- Utilizing a −100°C microplate CCD Imager, yttrium silicate coated 384-microplates and ultra-performance liquid chromatography for improved profiling of radiolabeled drug metabolites in complex biological samples
- (2008) G.J. Dear et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma
- (2008) G.J. Dear et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- General implementation of the ERETIC™ method for pulsed field gradient probe heads
- (2008) Fabio Ziarelli et al. JOURNAL OF MAGNETIC RESONANCE
- Comparison of a 250 kV single-stage accelerator mass spectrometer with a 5 MV tandem accelerator mass spectrometer - fitness for purpose in bioanalysis
- (2008) G. C. Young et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started