From definition to implementation: a cross-industry perspective of past, current and future MIST strategies

Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC–HR-MS

(2010) David Falck et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Determination of Exposure Multiples of Human Metabolites for MIST Assessment in Preclinical Safety Species without Using Reference Standards or Radiolabeled Compounds

(2010) Shuguang Ma et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments

(2010) H. Gao et al.   DRUG METABOLISM AND DISPOSITION

Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery

(2010) A. Mutlib et al.   DRUG METABOLISM AND DISPOSITION

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

(2010) W. W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance

(2010) Hongbin Yu et al.   Expert Opinion on Drug Metabolism & Toxicology

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR

(2010) Jon S.B. de Vlieger et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A radiocalibration method with pseudo internal standard to estimate circulating metabolite concentrations

(2010) Ping Yi et al.   Bioanalysis

Addressing metabolite safety during first-in-man studies using14C-labeled drug and accelerator mass spectrometry

(2010) Graham Lappin et al.   Bioanalysis

NMR spectroscopy as a tool to close the gap on metabolite characterization under MIST

(2010) Janet Caceres-Cortes et al.   Bioanalysis

Novel MS solutions inspired by MIST

(2010) Ragu Ramanathan et al.   Bioanalysis

Best practices in a tiered approach to metabolite quantification: views and recommendations of the European Bioanalysis Forum

(2010) Philip Timmerman et al.   Bioanalysis

An Accurate-Mass-Based Spectral-Averaging Isotope-Pattern-Filtering Algorithm for Extraction of Drug Metabolites Possessing a Distinct Isotope Pattern from LC-MS Data

(2009) Peijuan Zhu et al.   ANALYTICAL CHEMISTRY

Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations

(2009) Mingshe Zhu et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Safety Assessment of Drug Metabolites: Implications of Regulatory Guidance and Potential Application of Genetically Engineered Mouse Models that Express Human P450s

(2009) Mark W. Powley et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

(2009) Don Walker et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting Circulating Human Metabolites: How Good Are We?

(2009) Shelby Anderson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

(2009) Deepak Dalvie et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment

(2009) Dennis A. Smith et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries

(2009) A. Srivastava et al.   DRUG METABOLISM AND DISPOSITION

In vivomodeling of human liver for pharmacological study using humanized mouse

(2009) Katsutoshi Yoshizato et al.   Expert Opinion on Drug Metabolism & Toxicology

Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage

(2009) Gabriella Brolén et al.   JOURNAL OF BIOTECHNOLOGY

Human embryonic stem cell technologies and drug discovery

(2009) Janne Jensen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices

(2009) Peijuan Zhu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Metabolites in safety testing

(2009) Timothy W Robison et al.   Bioanalysis

Metabolite quantitation: detector technology and MIST implications

(2009) Pat Wright et al.   Bioanalysis

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

(2008) Karthick Vishwanathan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

(2008) Robert Espina et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolism and Disposition of Fluticasone Furoate, an Enhanced-Affinity Glucocorticoid, in Humans

(2008) S. C. Hughes et al.   DRUG METABOLISM AND DISPOSITION

Comparison of LC-NMR and conventional NMR for structure elucidation in drug metabolism studies

(2008) Gregory S Walker et al.   Expert Opinion on Drug Metabolism & Toxicology

Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics

(2008) Graham Lappin et al.   Expert Opinion on Drug Metabolism & Toxicology

Improved liquid chromatography—Online radioactivity detection for metabolite profiling

(2008) Filip Cuyckens et al.   JOURNAL OF CHROMATOGRAPHY A

Utilizing a −100°C microplate CCD Imager, yttrium silicate coated 384-microplates and ultra-performance liquid chromatography for improved profiling of radiolabeled drug metabolites in complex biological samples

(2008) G.J. Dear et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma

(2008) G.J. Dear et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

General implementation of the ERETIC™ method for pulsed field gradient probe heads

(2008) Fabio Ziarelli et al.   JOURNAL OF MAGNETIC RESONANCE

Comparison of a 250 kV single-stage accelerator mass spectrometer with a 5 MV tandem accelerator mass spectrometer - fitness for purpose in bioanalysis

(2008) G. C. Young et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use ofin silicophysiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man

(2008) G. Allan et al.   XENOBIOTICA