Addressing metabolite safety during first-in-man studies using14C-labeled drug and accelerator mass spectrometry

Accelerator mass spectrometry best practices for accuracy and precision in bioanalytical14C measurements

(2010) John S Vogel et al.   Bioanalysis

Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

(2009) Laurent Leclercq et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting Circulating Human Metabolites: How Good Are We?

(2009) Shelby Anderson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials

(2009) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY

Microdose Clinical Trial: Quantitative Determination of Nicardipine and Prediction of Metabolites in Human Plasma

(2009) Naoe Yamane et al.   Drug Metabolism and Pharmacokinetics

Microdose Pharmacokinetics of IDX899 and IDX989, Candidate HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors, Following Oral and Intravenous Administration in Healthy Male Subjects

(2009) Xiao-Jian Zhou et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

(2008) Karthick Vishwanathan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

(2008) Robert Espina et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The utility of microdosing over the past 5 years

(2008) Graham Lappin et al.   Expert Opinion on Drug Metabolism & Toxicology

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma

(2008) G.J. Dear et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Comparison of a 250 kV single-stage accelerator mass spectrometer with a 5 MV tandem accelerator mass spectrometer - fitness for purpose in bioanalysis

(2008) G. C. Young et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY