Metabolite quantitation: detector technology and MIST implications

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development

(2008) Filip Cuyckens et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Determinants for Optimal Enhancement in Ex Situ DNP Experiments

(2008) A.-H. Emwas et al.   APPLIED MAGNETIC RESONANCE

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

(2008) Karthick Vishwanathan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

(2008) Robert Espina et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Unique/Major Human Metabolites: Why, How, and When to Test for Safety in Animals

(2008) Debra Luffer-Atlas   DRUG METABOLISM REVIEWS

Comparison of metabolite profiles generated in Aroclor-induced rat liver and human liver subcellular fractions: Considerations for in vitro genotoxicity hazard assessment

(2008) R. Scott Obach et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies

(2008) Bente Gammelgaard et al.   Expert Opinion on Drug Metabolism & Toxicology

Comparison of LC-NMR and conventional NMR for structure elucidation in drug metabolism studies

(2008) Gregory S Walker et al.   Expert Opinion on Drug Metabolism & Toxicology

Quantitative comparison of a corona-charged aerosol detector and an evaporative light-scattering detector for the analysis of a synthetic polymer by supercritical fluid chromatography

(2008) Kayori Takahashi et al.   JOURNAL OF CHROMATOGRAPHY A

Investigation of interaction between salmeterol and fluticasone propionate and its effect on quantitative accuracy of an LC/MS/MS assay in human plasma at low pg/mL concentrations

(2008) Spencer J. Carter et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Comparison of HPLC with electrochemical detection and LC–MS/MS for the separation and validation of artesunate and dihydroartemisinin in animal and human plasma

(2008) Yuanchao Gu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma

(2008) G.J. Dear et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Parahydrogen induced polarization of barbituric acid derivatives:1H hyperpolarization studies

(2008) Meike Roth et al.   MAGNETIC RESONANCE IN CHEMISTRY

Quantitative metabolomics using NMR

(2008) David S. Wishart   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Superheated water chromatography – A green technology for the future

(2007) Roger M. Smith   JOURNAL OF CHROMATOGRAPHY A