Novel MS solutions inspired by MIST

Quantitative determination of hippuric and benzoic acids in urine by LC–MS/MS using surrogate standards

(2010) Natalia Penner et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Predicting Circulating Human Metabolites: How Good Are We?

(2009) Shelby Anderson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

(2009) Deepak Dalvie et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity

(2009) David Ross et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices

(2009) Peijuan Zhu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity

(2009) Sudipta Saha et al.   TOXICOLOGY LETTERS

Metabolites in safety testing

(2009) Timothy W Robison et al.   Bioanalysis

Metabolite quantitation: detector technology and MIST implications

(2009) Pat Wright et al.   Bioanalysis

High-performance liquid chromatography–tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites

(2008) M. Holčapek et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

(2008) Karthick Vishwanathan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

(2008) Robert Espina et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Species Scaling and Extrapolation

(2008) Virendra Gomase et al.   CURRENT DRUG METABOLISM

Species selection considerations for preclinical toxicology studies for biotherapeutics

(2008) Jeanine L Bussiere   Expert Opinion on Drug Metabolism & Toxicology

Prediction of oral drug absorption in humans – from cultured cell lines and experimental animals

(2008) K-C Cheng et al.   Expert Opinion on Drug Metabolism & Toxicology

An algorithm for thorough background subtraction from high-resolution LC/MS data: application to the detection of troglitazone metabolites in rat plasma, bile, and urine

(2008) Haiying Zhang et al.   JOURNAL OF MASS SPECTROMETRY

Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies

(2008) Philip R. Tiller et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection

(2008) Haiying Zhang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a ‘first-line’ approach for metabolite identification studies

(2008) Philip R. Tiller et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection

(2007) Qian Ruan et al.   JOURNAL OF MASS SPECTROMETRY