Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates

Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743

(2015) Michael M. Schofield et al.   ENVIRONMENTAL MICROBIOLOGY

Emerging Concepts Promising New Horizons for Marine Biodiscovery and Synthetic Biology

(2015) F. Reen et al.   Marine Drugs

Marine natural products

(2015) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Clustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites

(2015) Lin Tao et al.   Scientific Reports

Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis

(2015) Yongxin Li et al.   Scientific Reports

Sonorensin: an Antimicrobial Peptide, Belonging to the Heterocycloanthracin Subfamily of Bacteriocins, from a New Marine Isolate, Bacillus sonorensis MT93

(2014) Lipsy Chopra et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

Direct Capture and Heterologous Expression of Salinispora Natural Product Genes for the Biosynthesis of Enterocin

(2014) Bailey Bonet et al.   JOURNAL OF NATURAL PRODUCTS

Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds

(2014) Javier Rocha-Martin et al.   Marine Drugs

Polyketide Synthases in the Microbiome of the Marine Sponge Plakortis halichondrioides: A Metagenomic Update

(2014) Gerardo Della Sala et al.   Marine Drugs

Hyaluromycin, a New Hyaluronidase Inhibitor of Polyketide Origin from Marine Streptomyces sp.

(2014) Enjuro Harunari et al.   Marine Drugs

Mass spectrometry of natural products: current, emerging and future technologies

(2014) Amina Bouslimani et al.   NATURAL PRODUCT REPORTS

A talented genus

(2014) Marcel Jaspars et al.   NATURE

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont

(2014) Toshiyuki Wakimoto et al.   Nature Chemical Biology

Escherichia coli as a cell factory for heterologous production of nonribosomal peptides and polyketides

(2014) Jian Li et al.   New Biotechnology

Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products

(2014) Marnix H. Medema et al.   PLoS Computational Biology

Synthetic biology approaches to improve biocatalyst identification in metagenomic library screening

(2014) María-Eugenia Guazzaroni et al.   Microbial Biotechnology

The Psymberin Story-Biological Properties and Approaches towards Total and Analogue Syntheses

(2013) Max Bielitza et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents

(2013) Qian-Ru Du et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Defensive Bacteriome Symbiont with a Drastically Reduced Genome

(2013) Atsushi Nakabachi et al.   CURRENT BIOLOGY

Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives

(2013) Safinaz E. Abbas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges

(2013) Jason N Woodhouse et al.   ISME Journal

Dual evaluation of some novel 2-amino-substituted coumarinylthiazoles as anti-inflammatory–antimicrobial agents and their docking studies with COX-1/COX-2 active sites

(2013) Navneet Chandak et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Response surface methodology for optimising the culture conditions for eicosapentaenoic acid production by marine bacteria

(2013) Ahmed Abd Elrazak et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Thalassospiramide G, a New γ-Amino-Acid-Bearing Peptide from the Marine Bacterium Thalassospira sp.

(2013) Soohyun Um et al.   Marine Drugs

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Antimicrobial Activity of Heterotrophic Bacterial Communities from the Marine Sponge Erylus discophorus (Astrophorida, Geodiidae)

(2013) Ana Patrícia Graça et al.   PLoS One

Polyketide genes in the marine spongePlakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts

(2013) Gerardo Della Sala et al.   Environmental Microbiology Reports

Polyketide Synthase Gene Diversity within the Microbiome of the Sponge Arenosclera brasiliensis, Endemic to the Southern Atlantic Ocean

(2012) Amaro E. Trindade-Silva et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Functional assignment of metagenomic data: challenges and applications

(2012) T. Prakash et al.   BRIEFINGS IN BIOINFORMATICS

Current opportunities and challenges in microbial metagenome analysis--a bioinformatic perspective

(2012) H. Teeling et al.   BRIEFINGS IN BIOINFORMATICS

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

(2012) William H. Gerwick et al.   CHEMISTRY & BIOLOGY

A functional screen for recovery of 4′-phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries

(2012) J. G. Owen et al.   ENVIRONMENTAL MICROBIOLOGY

Origin and Variation of Tunicate Secondary Metabolites

(2012) Eric W. Schmidt et al.   JOURNAL OF NATURAL PRODUCTS

Genomic Mining for Novel FADH2-Dependent Halogenases in Marine Sponge-Associated Microbial Consortia

(2012) Kristina Bayer et al.   MARINE BIOTECHNOLOGY

Diversity of Nonribosomal Peptide Synthetase Genes in the Microbial Metagenomes of Marine Sponges

(2012) Sheila Marie Pimentel-Elardo et al.   Marine Drugs

Antioxidant and Anti-Protease Activities of Diazepinomicin from the Sponge-Associated Micromonospora Strain RV115

(2012) Usama Ramadan Abdelmohsen et al.   Marine Drugs

Computational tools for the synthetic design of biochemical pathways

(2012) Marnix H. Medema et al.   NATURE REVIEWS MICROBIOLOGY

Trends in the Discovery of New Marine Natural Products from Invertebrates over the Last Two Decades – Where and What Are We Bioprospecting?

(2012) Miguel Costa Leal et al.   PLoS One

Genome streamlining and chemical defense in a coral reef symbiosis

(2012) J. C. Kwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

The Second Skin: Ecological Role of Epibiotic Biofilms on Marine Organisms

(2012) Martin Wahl et al.   Frontiers in Microbiology

Meta-omic Characterization of the Marine Invertebrate Microbial Consortium That Produces the Chemotherapeutic Natural Product ET-743

(2011) Christopher M. Rath et al.   ACS Chemical Biology

Next generation sequencing and bioinformatic bottlenecks: the current state of metagenomic data analysis

(2011) Matthew B. Scholz et al.   CURRENT OPINION IN BIOTECHNOLOGY

Targeted metagenomics: a high-resolution metagenomics approach for specific gene clusters in complex microbial communities

(2011) Hikaru Suenaga   ENVIRONMENTAL MICROBIOLOGY

Marine natural products: a new wave of drugs?

(2011) Rana Montaser et al.   Future Medicinal Chemistry

Bacterial Production of the Tunicate-Derived Antitumor Cyclic Depsipeptide Didemnin B

(2011) Moriya Tsukimoto et al.   JOURNAL OF NATURAL PRODUCTS

Statistical Research on Marine Natural Products Based on Data Obtained between 1985 and 2008

(2011) Gu-Ping Hu et al.   Marine Drugs

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

A mass spectrometry–guided genome mining approach for natural product peptidogenomics

(2011) Roland D Kersten et al.   Nature Chemical Biology

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis

(2011) M. S. Donia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity in natural product families is governed by more than enzyme promiscuity alone: establishing control of the pacidamycin portfolio

(2011) Sabine Grüschow et al.   Chemical Science

Directed Culturing of Microorganisms Using Metatranscriptomics

(2011) L. Bomar et al.   mBio

Expanding Small-Molecule Functional Metagenomics through Parallel Screening of Broad-Host-Range Cosmid Environmental DNA Libraries in Diverse Proteobacteria

(2010) J. W. Craig et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Engineered polyketide biosynthesis and biocatalysis in Escherichia coli

(2010) Xue Gao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cloning large natural product gene clusters from the environment: Piecing environmental DNA gene clusters back together with TAR

(2010) Jeffrey H. Kim et al.   BIOPOLYMERS

Linking Chemical and Microbial Diversity in Marine Sponges: Possible Role for Poribacteria as Producers of Methyl-Branched Fatty Acids

(2010) Thomas Hochmuth et al.   CHEMBIOCHEM

Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules

(2010) Jacob J Banik et al.   CURRENT OPINION IN MICROBIOLOGY

Global patterns in the biogeography of bacterial taxa

(2010) Diana R. Nemergut et al.   ENVIRONMENTAL MICROBIOLOGY

Strategies for culture of ‘unculturable’ bacteria

(2010) Sonia R. Vartoukian et al.   FEMS MICROBIOLOGY LETTERS

Diversity of Monomers in Nonribosomal Peptides: towards the Prediction of Origin and Biological Activity

(2010) S. Caboche et al.   JOURNAL OF BACTERIOLOGY

Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge

(2010) Toshiyuki Hamada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antiviral Lead Compounds from Marine Sponges

(2010) Sunil Sagar et al.   Marine Drugs

Marine Metagenomics: New Tools for the Study and Exploitation of Marine Microbial Metabolism

(2010) Jonathan Kennedy et al.   Marine Drugs

Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment

(2010) Wael M. Abdel-Mageed et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Size does matter: Application-driven approaches for soil metagenomics

(2010) Kavita S. Kakirde et al.   SOIL BIOLOGY & BIOCHEMISTRY

Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation

(2010) Anne Osbourn   TRENDS IN GENETICS

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Metagenomic gene discovery: How far have we moved into novel sequence space?

(2009) Marla Tuffin et al.   Biotechnology Journal

Functional metagenomics for enzyme discovery: challenges to efficient screening

(2009) Taku Uchiyama et al.   CURRENT OPINION IN BIOTECHNOLOGY

Bioactive compounds from marine actinomycetes

(2009) Renu Solanki et al.   INDIAN JOURNAL OF MICROBIOLOGY

Antineoplastic Agents. 570. Isolation and Structure Elucidation of Bacillistatins 1 and 2 from a MarineBacillus silvestris†,‡

(2009) George R. Pettit et al.   JOURNAL OF NATURAL PRODUCTS

Antitumor Compounds from Marine Actinomycetes

(2009) Carlos Olano et al.   Marine Drugs

Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

(2009) Katja M Fisch et al.   Nature Chemical Biology

PKS and NRPS gene clusters from microbial symbiont cells of marine sponges by whole genome amplification

(2009) Alexander Siegl et al.   Environmental Microbiology Reports

Metagenome-Derived Clones Encoding Two Novel Lactonase Family Proteins Involved in Biofilm Inhibition in Pseudomonas aeruginosa

(2008) C. Schipper et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Secondary Metabolites Produced by the Marine Bacterium Halobacillus salinus That Inhibit Quorum Sensing-Controlled Phenotypes in Gram-Negative Bacteria

(2008) M. E. Teasdale et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Diversity of microbes associated with the marine sponge, Haliclona simulans, isolated from Irish waters and identification of polyketide synthase genes from the sponge metagenome

(2008) Jonathan Kennedy et al.   ENVIRONMENTAL MICROBIOLOGY

Metagenomics for Mining New Genetic Resources of Microbial Communities

(2008) Manuel Ferrer et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine CyanobacteriumSymplocasp.

(2008) Kanchan Taori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drug development from marine natural products

(2008) Tadeusz F. Molinski et al.   NATURE REVIEWS DRUG DISCOVERY