The Psymberin Story-Biological Properties and Approaches towards Total and Analogue Syntheses

Synthesis of 8-Desmethoxy Psymberin: A Putative Biosynthetic Intermediate Towards the Marine Polyketide Psymberin

(2013) Max Bielitza et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of (+)-Irciniastatin A (a.k.a. Psymberin) and (−)-Irciniastatin B

(2013) Chihui An et al.   JOURNAL OF ORGANIC CHEMISTRY

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

(2012) William H. Gerwick et al.   CHEMISTRY & BIOLOGY

An Ammonia-Triggered Stereocontrolled Conversion of a γ-Lactone to the Central Tetrahydropyran of Pederin, Psymberin, and Onnamides D-F

(2012) William J. Buffham et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Studies toward the Unique Pederin Family Member Psymberin: Structure–Activity Relationships, Biochemical Studies, and Genetics Identify the Mode-of-Action of Psymberin

(2012) Cheng-Yang Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Studies toward the Unique Pederin Family Member Psymberin: Full Structure Elucidation, Two Alternative Total Syntheses, and Analogs

(2012) Yu Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mycalamides, Pederin and Psymberin as Natural Carbohydrates and Potential Antitumor Agents: Past and Future Perspectives

(2012) Zbigniew J. Witczak et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products

(2012) R. Adam Mosey et al.   NATURAL PRODUCT REPORTS

Insights from the sea: Structural biology of marine polyketide synthases

(2012) David L. Akey et al.   NATURAL PRODUCT REPORTS

Total Synthesis of (−)-Irciniastatin B and Structural Confirmation via Chemical Conversion to (+)-Irciniastatin A (Psymberin)

(2012) Chihui An et al.   ORGANIC LETTERS

Isocoumarin and Its Derivatives: An Overview on their Synthesis and Applications

(2011) Sarbani Pal et al.   CURRENT ORGANIC CHEMISTRY

Stereoselective Synthesis of Tetrahydropyrans through Tandem and Organocatalytic Oxa-Michael Reactions: Synthesis of the Tetrahydropyran Cores of ent-(+)-Sorangicin A

(2011) Kiyoun Lee et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

An Enantioselective Approach toward 3,4-Dihydroisocoumarin through the Bromocyclization of Styrene-type Carboxylic Acids

(2011) Jie Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis and Biological Evaluation of Pederin, Psymberin, and Highly Potent Analogs

(2011) Shuangyi Wan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Synthesis of 2,6-trans-Tetrahydropyran via Primary Diamine-Catalyzed Oxa-Conjugate Addition Reaction of α,β-Unsaturated Ketone: Total Synthesis of Psymberin

(2011) Seong Rim Byeon et al.   ORGANIC LETTERS

Total Synthesis of Pederin and Analogues

(2010) Fanghui Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Requirements for the Antiproliferative Activity of Pre-mRNA Splicing Inhibitor FR901464

(2010) Sami Osman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Chiral 3-Alkyl-3,4-dihydroisocoumarins by Dynamic Kinetic Resolutions Catalyzed by a Baeyer−Villiger Monooxygenase

(2010) Ana Rioz-Martínez et al.   JOURNAL OF ORGANIC CHEMISTRY

Syntheses and Biological Evaluation of Irciniastatin A and the C1−C2 Alkyne Analogue

(2010) Tsubasa Watanabe et al.   ORGANIC LETTERS

Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation

(2010) Chunliang Lu et al.   ORGANIC LETTERS

Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway

(2010) Takumi Chinen et al.   TOXICOLOGY LETTERS

Chemoenzymatic Synthesis of (Protected) Psymberic Acid

(2009) Jörg Pietruszka et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Progress toward the Total Synthesis of Psymberin/Irciniastatin A

(2009) Lauren E. Brown et al.   JOURNAL OF ORGANIC CHEMISTRY

Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

(2009) Katja M Fisch et al.   Nature Chemical Biology

The Discovery of Potent Antitumor Agent C11-Deoxypsymberin/irciniastatin A: Total Synthesis and Biology of Advanced Psymberin Analogs

(2009) Xianhai Huang et al.   ORGANIC LETTERS

Total Synthesis of Irciniastatin A (Psymberin)

(2009) Michael T. Crimmins et al.   ORGANIC LETTERS

Multicomponent Synthesis of α-Branched Amides

(2009) Mikkel V. DeBenedetto et al.   ORGANIC LETTERS

New Applications of PhI(OAc)2 in Synthesis: Total Synthesis and SAR Development of Potent Antitumor Natural Product Psymberin/Irciniastatin A

(2009) Ning Shao et al.   SYNTHESIS-STUTTGART

A new approach to the synthesis of 3,4-dihydroisocoumarin derivatives

(2009) Mykola D. Obushak et al.   TETRAHEDRON LETTERS

Enantioselective Synthesis of Spirocyclic Benzopyranones by Rhodium‐Catalyzed Intermolecular [4+2] Annulation

(2008) Daiki Hojo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient and flexible synthesis of chiral γ- and δ-lactones

(2008) Andreas Habel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis of (+)-Psymberin (Irciniastatin A): Catalytic Reagent Control as the Strategic Cornerstone

(2008) Amos B. Smith et al.   ORGANIC LETTERS

One-Pot Synthesis of Bicyclic β-Alkoxy Amides from Cyanohydrin Ethers

(2008) Qing Xiao et al.   ORGANIC LETTERS

Synthesis of six-membered oxygenated heterocycles through carbon–oxygen bond-forming reactions

(2008) Igor Larrosa et al.   TETRAHEDRON

Titanocene(III) chloride mediated radical-induced synthesis of 3,4-dihydroisocoumarins: synthesis of (±)-hydrangenol, (±)-phyllodulcin, (±)-macrophyllol and (±)-thunberginol G

(2008) Samir Kumar Mandal et al.   TETRAHEDRON

Synthetic studies toward the pyran core and the amide side chain of psymberin

(2008) Hugo Lachance et al.   TETRAHEDRON LETTERS

Synthesis of seco-psymberin/irciniastatin A: the discovery of a novel PhI(OAc)2 mediated cascade cyclization reaction

(2008) Xianhai Huang et al.   TETRAHEDRON LETTERS

Synthesis of 3-aryl-3,4-dihydroisocoumarins by regioselective domino ‘[3+3] cyclization/lactonization’ reactions of 1,3-bis-(silyloxy)-1,3-butadienes with 1-hydroxy-5-silyloxy-4-en-3-ones

(2008) Muhammad Sher et al.   TETRAHEDRON LETTERS