Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

(2015) Faezeh Vasheghani et al.   ANNALS OF THE RHEUMATIC DISEASES

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

(2015) E. Kozhemyakina et al.   DEVELOPMENT

The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone

(2015) K. Takebe et al.   OSTEOARTHRITIS AND CARTILAGE

A new prescription for growth? Statins, cholesterol and cartilage homeostasis

(2015) J.R. Bush et al.   OSTEOARTHRITIS AND CARTILAGE

Adult Mice Lacking the Type 2 Iodothyronine Deiodinase Have Increased Subchondral Bone but Normal Articular Cartilage

(2015) Julian A. Waung et al.   THYROID

Peroxisome Proliferator-Activated Receptor δ Promotes the Progression of Posttraumatic Osteoarthritis in a Mouse Model

(2015) A. Ratneswaran et al.   Arthritis & Rheumatology

The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

(2014) Marita Cross et al.   ANNALS OF THE RHEUMATIC DISEASES

Chondrocyte hypertrophy in skeletal development, growth, and disease

(2014) Margaret Man-Ger Sun et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Is there such a thing as a cartilage-specific knockout mouse?

(2014) Michael A. Pest et al.   Nature Reviews Rheumatology

Mouse models of osteoarthritis: modelling risk factors and assessing outcomes

(2014) Hang Fang et al.   Nature Reviews Rheumatology

Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis

(2014) T. Weng et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation

(2014) B. Staal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury

(2014) Danese M Joiner et al.   ARTHRITIS RESEARCH & THERAPY

Targeting subchondral bone in osteoporotic osteoarthritis

(2014) Jorge A Roman-Blas et al.   ARTHRITIS RESEARCH & THERAPY

Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

(2014) Gary J. Litherland et al.   Arthritis & Rheumatology

Dkk-1-Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice

(2014) Thomas Funck-Brentano et al.   Arthritis & Rheumatology

Disturbed Cartilage and Joint Homeostasis Resulting From a Loss of Mitogen-Inducible Gene 6 in a Mouse Model of Joint Dysfunction

(2014) Michael A. Pest et al.   Arthritis & Rheumatology

Depletion of Protease-Activated Receptor 2 but Not Protease-Activated Receptor 1 May Confer Protection Against Osteoarthritis in Mice Through Extracartilaginous Mechanisms

(2014) Miriam T. Jackson et al.   Arthritis & Rheumatology

Adult Cartilage-Specific Peroxisome Proliferator–Activated Receptor Gamma Knockout Mice Exhibit the Spontaneous Osteoarthritis Phenotype

(2013) Faezeh Vasheghani et al.   AMERICAN JOURNAL OF PATHOLOGY

Enhancement of the synthesis of n-3 PUFAs infat-1transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice

(2013) Min-jun Huang et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice—a translational model for atherosclerosis

(2013) L M Gierman et al.   ANNALS OF THE RHEUMATIC DISEASES

Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Epiphyseal Cartilage Development through β-Catenin-dependent and -independent Pathways

(2013) Xianrong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synovial perlecan is required for osteophyte formation in knee osteoarthritis

(2013) Haruka Kaneko et al.   MATRIX BIOLOGY

TGF-β and osteoarthritis—the good and the bad

(2013) Jason R Bush et al.   NATURE MEDICINE

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Interleukin 6 mediates selected effects of Notch in chondrocytes

(2013) S. Zanotti et al.   OSTEOARTHRITIS AND CARTILAGE

Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo

(2013) John B Shepard et al.   ARTHRITIS RESEARCH & THERAPY

Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis

(2013) Wouter de Munter et al.   ARTHRITIS RESEARCH & THERAPY

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis

(2012) Carol G. Chen et al.   ARTHRITIS AND RHEUMATISM

Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet

(2012) I.-E. Triantaphyllidou et al.   OSTEOARTHRITIS AND CARTILAGE

Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

(2012) Thomas Funck-Brentano et al.   PLoS One

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early diagnosis to enable early treatment of pre-osteoarthritis

(2012) Constance R Chu et al.   ARTHRITIS RESEARCH & THERAPY

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model

(2011) Roxana Monemdjou et al.   ARTHRITIS AND RHEUMATISM

Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice

(2011) L. M. Gierman et al.   ARTHRITIS AND RHEUMATISM

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

New Hope for the Treatment of Osteoarthritis Through Selective Inhibition of MMP-13

(2011) N.-G. Li et al.   CURRENT MEDICINAL CHEMISTRY

The Critical Role of the Epidermal Growth Factor Receptor in Endochondral Ossification

(2011) Xianrong Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Cartilage biology in osteoarthritis—lessons from developmental biology

(2011) Andrew A. Pitsillides et al.   Nature Reviews Rheumatology

IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritis

(2011) L. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility

(2010) I. Meulenbelt et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Is Cartilage Matrix Breakdown an Appropriate Therapeutic Target in Osteoarthritis – Insights from Studies of Aggrecan and Collagen Proteolysis?

(2010) Christopher B. Little et al.   CURRENT DRUG TARGETS

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Diagnostic Utility of Cytokine Biomarkers in the Evaluation of Acute Knee Pain

(2009) Jason M Cuellar et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation

(2009) C Thomas G Appleton et al.   LABORATORY INVESTIGATION

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

15-Hydroxyeicosatetraenoic Acid Is a Preferential Peroxisome Proliferator-Activated Receptor  /  Agonist

(2009) S. Naruhn et al.   MOLECULAR PHARMACOLOGY

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Wnt signaling and osteoarthritis

(2008) Frank P. Luyten et al.   BONE

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

(2008) Takahito Yuasa et al.   LABORATORY INVESTIGATION

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity

(2008) Morten A Karsdal et al.   ARTHRITIS RESEARCH & THERAPY

Drug Insight: aggrecanases as therapeutic targets for osteoarthritis

(2008) Amanda J Fosang et al.   Nature clinical practice. Rheumatology

Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists

(2007) Ramya Kapadia   Frontiers in Bioscience-Landmark