ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies

Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency

(2015) M. A. J. Prasad et al.   BLOOD

Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia

(2015) R. Somasundaram et al.   BLOOD

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia

(2015) Louise van der Weyden et al.   BMC CANCER

Analyse multiple disease subtypes and build associated gene networks using genome-wide expression profiles

(2015) Sara Aibar et al.   BMC GENOMICS

miR-195a Inhibits Adipocyte Differentiation by Targeting the Preadipogenic DeterminatorZfp423

(2015) Ui Jeong Yun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Combined heterozygous loss ofEbf1andPax5allows for T-lineage conversion of B cell progenitors

(2015) Jonas Ungerbäck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Incoherent Feed-Forward Regulatory Loops Control Segregation of C-Mechanoreceptors, Nociceptors, and Pruriceptors

(2015) S. Lou et al.   JOURNAL OF NEUROSCIENCE

Validation of a Novel Shotgun Proteomic Workflow for the Discovery of Protein–Protein Interactions: Focus on ZNF521

(2015) Francesca Bernaudo et al.   JOURNAL OF PROTEOME RESEARCH

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

(2015) Anna K Andersson et al.   NATURE GENETICS

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

(2015) Vincent-Philippe Lavallée et al.   NATURE GENETICS

ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway

(2015) T Hiratsuka et al.   ONCOGENE

AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation

(2015) Yunbo Qiao et al.   Cell Discovery

Computational Modeling of a Transcriptional Switch Underlying B-Lymphocyte Lineage Commitment of Hematopoietic Multipotent Cells

(2015) Luca Salerno et al.   PLoS One

Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells.

(2015) Raffaella Spina et al.   Oncotarget

Transcriptional Control of Early T and B Cell Developmental Choices

(2014) Ellen V. Rothenberg   Annual Review of Immunology

Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

(2014) Y. Aoki et al.   BLOOD

Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors

(2014) Jonah Riddell et al.   CELL

Genetically engineered mouse models of human B-cell precursor leukemias

(2014) Julia Hauer et al.   CELL CYCLE

The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function

(2014) Sören Boller et al.   IMMUNOLOGICAL REVIEWS

Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function

(2014) Carissa Dege et al.   IMMUNOLOGICAL REVIEWS

EBF1 Is Essential for B-Lineage Priming and Establishment of a Transcription Factor Network in Common Lymphoid Progenitors

(2014) S. Zandi et al.   JOURNAL OF IMMUNOLOGY

Expression Profiling and Functional Implications of a Set of Zinc Finger Proteins, ZNF423, ZNF470, ZNF521, and ZNF780B, in Primary Osteoarthritic Articular Chondrocytes

(2014) Maria Mesuraca et al.   MEDIATORS OF INFLAMMATION

Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch

(2014) William N. Addison et al.   MOLECULAR AND CELLULAR BIOLOGY

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes

(2014) Katrin K Fleischmann et al.   Molecular Cancer

Stage-specific control of early B cell development by the transcription factor Ikaros

(2014) Tanja A Schwickert et al.   NATURE IMMUNOLOGY

Abnormal Behaviors and Developmental Disorder of Hippocampus in Zinc Finger Protein 521 (ZFP521) Mutant Mice

(2014) Nobutaka Ohkubo et al.   PLoS One

The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?

(2014) Mohamed Amin Choukrallah et al.   Frontiers in Immunology

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

(2013) E. Bolton-Gillespie et al.   BLOOD

Complementary regulation of early B-lymphoid differentiation by genetic and epigenetic mechanisms

(2013) Takafumi Yokota et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome ofETV6-RUNX1negative B precursor acute lymphoblastic leukemia

(2013) Lena Harder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages

(2013) Riku Kiviranta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia

(2013) D S Mangum et al.   LEUKEMIA

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

(2013) Sohela Shah et al.   NATURE GENETICS

Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells

(2013) Robert Nechanitzky et al.   NATURE IMMUNOLOGY

Zfp423 Binds Autoregulatory Sites in P19 Cell Culture Model

(2013) Young-Wook Cho et al.   PLoS One

WISP2 regulates preadipocyte commitment and PPAR  activation by BMP4

(2013) A. Hammarstedt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Estrogen Receptor Modulators and Pharmacogenomic Variation in ZNF423 Regulation of BRCA1 Expression: Individualized Breast Cancer Prevention

(2013) J. N. Ingle et al.   Cancer Discovery

Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells

(2013) Roi Gazit et al.   Stem Cell Reports

EBF1 acts as a powerful repressor of Blimp-1 gene expression in immature B cells

(2012) Hidehiko Kikuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

(2012) Moumita Chaki et al.   CELL

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

(2012) Rana K. Gupta et al.   Cell Metabolism

Essential role of EBF1 in the generation and function of distinct mature B cell types

(2012) Bojan Vilagos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MLL–AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny

(2012) S J Horton et al.   LEUKEMIA

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia

(2012) Dirk Heckl et al.   MOLECULAR THERAPY

Regulation of Early Adipose Commitment by Zfp521

(2012) Sona Kang et al.   PLOS BIOLOGY

Acute lymphoblastic leukemia and developmental biology

(2011) Elena Campos-Sanchez et al.   CELL CYCLE

Zinc finger protein 521 antagonizes early B-cell factor 1 and modulates the B-lymphoid differentiation of primary hematopoietic progenitors

(2011) Tiziana Mega et al.   CELL CYCLE

A dose-dependent role for EBF1 in repressing non-B-cell-specific genes

(2011) Kara Lukin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ebf1orPax5haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

(2011) Lynn M. Heltemes-Harris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrinsic transition of embryonic stem-cell differentiation into neural progenitors

(2011) Daisuke Kamiya et al.   NATURE

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

(2010) R. C. Harvey et al.   BLOOD

Transcription control of early B cell differentiation

(2010) Elizabeth M Mandel et al.   CURRENT OPINION IN IMMUNOLOGY

Awakening lineage potential by Ikaros-mediated transcriptional priming

(2010) Toshimi Yoshida et al.   CURRENT OPINION IN IMMUNOLOGY

Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin

(2010) Thomas Treiber et al.   IMMUNITY

ZFP423 Coordinates Notch and Bone Morphogenetic Protein Signaling, Selectively Up-regulatingHes5Gene Expression

(2010) Giacomo Masserdotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity

(2010) Eric Hesse et al.   JOURNAL OF CELL BIOLOGY

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group

(2010) Torsten Haferlach et al.   JOURNAL OF CLINICAL ONCOLOGY

Transcriptional control of preadipocyte determination by Zfp423

(2010) Rana K. Gupta et al.   NATURE

Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia

(2010) N Yamasaki et al.   ONCOGENE

Enhanced expression ofp210BCR/ABLand aberrant expression ofZfp423/ZNF423induce blast crisis of chronic myelogenous leukemia

(2009) Kazuko Miyazaki et al.   BLOOD

ZNF423 Is Critically Required for Retinoic Acid-Induced Differentiation and Is a Marker of Neuroblastoma Outcome

(2009) Sidong Huang et al.   CANCER CELL

Early Hematopoietic Zinc Finger Protein Prevents Tumor Cell Recognition by Natural Killer Cells

(2009) R. La Rocca et al.   JOURNAL OF IMMUNOLOGY

Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5

(2009) H. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia

(2008) J. J. Yang et al.   BLOOD

Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo

(2008) Meilin Wu et al.   BONE

Ebf1-dependent control of the osteoblast and adipocyte lineages

(2008) David G.T. Hesslein et al.   BONE

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

(2008) Junping Wei et al.   CANCER CELL

The Role of Zinc Finger Protein 521/Early Hematopoietic Zinc Finger Protein in Erythroid Cell Differentiation

(2008) Etsuko Matsubara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pivotal role of early B‐cell factor 1 in development of striatonigral medium spiny neurons in the matrix compartment

(2008) Mary Kay Lobo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The ‘zinc knuckle’ motif of Early B cell Factor is required for transcriptional activation of B cell-specific genes

(2008) Scott Fields et al.   MOLECULAR IMMUNOLOGY

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE

Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5

(2008) Jagan M R Pongubala et al.   NATURE IMMUNOLOGY

Early hematopoietic zinc finger protein—zinc finger protein 521: A candidate regulator of diverse immature cells

(2007) Heather M. Bond et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY