Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

(2012) M. Nieborowska-Skorska et al.   BLOOD

Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia

(2012) Bin Zhang et al.   CANCER CELL

A Sensitive and Quantitative Polymerase Chain Reaction-Based Cell Free In Vitro Non-Homologous End Joining Assay for Hematopoietic Stem Cells

(2012) Lijian Shao et al.   PLoS One

BCR-ABL1 kinase domain mutations: Methodology and clinical evaluation

(2011) Mary Alikian et al.   AMERICAN JOURNAL OF HEMATOLOGY

CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia

(2011) H. Makishima et al.   BLOOD

Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

(2011) S. Chu et al.   BLOOD

Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease

(2011) J.-C. Chomel et al.   BLOOD

Advances in the treatment of chronic myeloid leukemia

(2011) Anna M Eiring et al.   BMC Medicine

Suboptimal responses in chronic myeloid leukemia

(2011) Elias Jabbour et al.   CANCER

Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia

(2011) Thomas Schmidt et al.   CANCER CELL

A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases

(2011) V Grossmann et al.   LEUKEMIA

Expression patterns of microRNAs associated with CML phases and their disease related targets

(2011) Kateřina Machová Poláková et al.   Molecular Cancer

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

(2010) M. Schemionek et al.   BLOOD

Rapid clonal shifts in response to kinase inhibitor therapy in chronic myelogenous leukemia are identified by quantitation mutation assays

(2010) C. Cameron Yin et al.   CANCER SCIENCE

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

Chronic myeloid leukemia: mechanisms of blastic transformation

(2010) Danilo Perrotti et al.   JOURNAL OF CLINICAL INVESTIGATION

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

(2010) Amie S. Corbin et al.   JOURNAL OF CLINICAL INVESTIGATION

Do we have to kill the last CML cell?

(2010) D M Ross et al.   LEUKEMIA

Genomic characterization of Imatinib resistance in CD34+ cell populations from chronic myeloid leukaemia patients

(2010) Sami Joha et al.   LEUKEMIA RESEARCH

Hematopoietic stem cell: self-renewal versus differentiation

(2010) Jun Seita et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

A single-array preprocessing method for estimating full-resolution raw copy numbers from all Affymetrix genotyping arrays including GenomeWideSNP 5 & 6

(2009) Henrik Bengtsson et al.   BIOINFORMATICS

Enhanced expression ofp210BCR/ABLand aberrant expression ofZfp423/ZNF423induce blast crisis of chronic myelogenous leukemia

(2009) Kazuko Miyazaki et al.   BLOOD

SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations

(2009) D. Nowak et al.   BLOOD

Similar patterns of chromosome abnormalities in CML occur in addition to the Philadelphia chromosome with or without tyrosine kinase inhibitor treatment

(2009) C Haferlach et al.   LEUKEMIA

A gene expression signature of primary resistance to imatinib in chronic myeloid leukemia

(2009) Hugues de Lavallade et al.   LEUKEMIA RESEARCH

PAK signaling in oncogenesis

(2009) P R Molli et al.   ONCOGENE

An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

(2008) Sean W. Deacon et al.   CHEMISTRY & BIOLOGY

Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia

(2008) D W Sherbenou et al.   LEUKEMIA

Multiple sub-microscopic genomic lesions are a universal feature of chronic myeloid leukaemia at diagnosis

(2008) J S Khorashad et al.   LEUKEMIA

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE