Glycodeoxycholic Acid Levels as Prognostic Biomarker in Acetaminophen-Induced Acute Liver Failure Patients

Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury

(2014) Sujith V. W. Weerasinghe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

(2014) Mitchell R. McGill et al.   BIOMARKERS

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

(2014) Mitchell R McGill et al.   Expert Opinion on Drug Metabolism & Toxicology

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

(2014) Mitchell R. McGill et al.   HEPATOLOGY

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

(2014) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice

(2014) Benjamin L. Woolbright et al.   TOXICOLOGY LETTERS

Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice

(2014) Ye-Fa Zhang et al.   TOXICOLOGY LETTERS

Role of Bile Acids in Liver Injury and Regeneration following Acetaminophen Overdose

(2013) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

(2013) Noémie Péan et al.   HEPATOLOGY

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis

(2013) Lars P. Bechmann et al.   HEPATOLOGY

Assessment of Emerging Biomarkers of Liver Injury in Human Subjects

(2013) Shelli Schomaker et al.   TOXICOLOGICAL SCIENCES

Evaluation of Serum Bile Acid Profiles as Biomarkers of Liver Injury in Rodents

(2013) Lina Luo et al.   TOXICOLOGICAL SCIENCES

Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice

(2013) Benjamin L. Woolbright et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats

(2013) Makoto Yamazaki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Development of an Accurate Index for Predicting Outcomes of Patients With Acute Liver Failure

(2012) Anna Rutherford et al.   GASTROENTEROLOGY

Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation

(2012) Jae-Hwi Jang et al.   HEPATOLOGY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C

(2012) A. Shlomai et al.   JOURNAL OF VIRAL HEPATITIS

Determining prognosis in acute liver failure

(2012) William M. Lee   Nature Reviews Gastroenterology & Hepatology

Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury

(2012) Hong-Min Ni et al.   TOXICOLOGICAL SCIENCES

Novel insight into mechanisms of cholestatic liver injury

(2012) Benjamin L Woolbright   WORLD JOURNAL OF GASTROENTEROLOGY

Can Plasma Bile Salt, Triglycerides, and apoA-V Levels Predict Liver Regeneration?

(2012) Lisette T. Hoekstra et al.   WORLD JOURNAL OF SURGERY

Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: A pilot study

(2011) Jocelyn Trottier et al.   DIGESTIVE AND LIVER DISEASE

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Effect of bile duct ligation on bile acid composition in mouse serum and liver

(2011) Youcai Zhang et al.   LIVER INTERNATIONAL

Profiling Circulating and Urinary Bile Acids in Patients with Biliary Obstruction before and after Biliary Stenting

(2011) Jocelyn Trottier et al.   PLoS One

Nitric oxide mimics transcriptional and post-translational regulation during α-Tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes

(2010) Raúl González et al.   JOURNAL OF HEPATOLOGY

Hepatocyte Death: A Clear and Present Danger

(2010) Harmeet Malhi et al.   PHYSIOLOGICAL REVIEWS

Contribution of High Basolateral Bile Salt Efflux to the Lack of Hepatotoxicity in Rat in Response to Drugs Inducing Cholestasis in Human

(2010) Katalin Jemnitz et al.   TOXICOLOGICAL SCIENCES

Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC–MS/MS

(2008) Yazen Alnouti et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES