Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

(2013) Mitchell R. McGill et al.   ARCHIVES OF TOXICOLOGY

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Assessment of Emerging Biomarkers of Liver Injury in Human Subjects

(2013) Shelli Schomaker et al.   TOXICOLOGICAL SCIENCES

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Elevated levels of the long pentraxin 3 in paracetamol-induced human acute liver injury

(2012) Darren G. Craig et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Emergency Department Visits for Overdoses of Acetaminophen-Containing Products

(2011) Daniel S. Budnitz et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Asymptomatic alanine aminotransferase elevations with therapeutic doses of acetaminophen

(2011) Kennon Heard   CLINICAL TOXICOLOGY

Inhibition of LPS toxicity by hepatic argininosuccinate synthase (ASS): Novel roles for ASS in innate immune responses to bacterial infection

(2011) Victor Prima et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The utilization of liver transplantation in the management of acute liver failure: Comparison between acetaminophen and non-acetaminophen etiologies

(2009) Kenneth J. Simpson et al.   LIVER TRANSPLANTATION

Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat

(2009) Yukitaka Yoshikawa et al.   TOXICOLOGY